A unique vaccine for control of fertility and therapy of advanced-stage terminal cancers ectopically expressing human chorionic gonadotropin

This article is a tribute and homage to Gerard Chaouat who invited me to contribute this article. My years in France have remained very memorable to me. Reviewed briefly is the vaccine that was made against human chorionic gonadotropin (hCG) to prevent unwanted pregnancy in sexually active women. It has now been developed as a genetically engineered recombinant vaccine and passed onto industry for its production under good manufacturing practices (GMP) conditions for confirmatory trials. The trials have received the approval of the Drugs Controller General of India. The trials have started but have been interrupted by the coronavirus disease 2019 (COVID-19) pandemic. This vaccine is likely to have another highly beneficial application in the treatment of cancers expressing ectopically hCG.

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Abstract #917: Injection of Human Chorionic Gonadotropin (HCG) Can Cause the Luteinized Unruptured Follicle Syndrome

Endocrine Practice ◽

10.1016/s1530-891x(20)42797-1 ◽

2015 ◽

Vol 21 ◽

pp. 186

Author(s):

Jerome Check ◽

Danyne Senft ◽

Michael Dougherty

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Luteinized Unruptured Follicle Syndrome ◽

Luteinized Unruptured Follicle

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Prurified anti-trophoblast antibodies (ATAB) suppress the secretion of human Chorionic Gonadotropin (hCG) and stimulate that of Plaminogen-Activator-Inhibitor Type 1 (PAI-1) in JEG-3 cells in vitro

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0036-1592760 ◽

2016 ◽

Vol 76 (10) ◽

Author(s):

Y Ye ◽

M Vogel ◽

P Burger ◽

N Rogenhofer ◽

S Mahner ◽

...

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Inhibitor Type ◽

Activator Inhibitor Type ◽

Activator Inhibitor ◽

Pai 1

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Human Chorionic Gonadotropin and CA 15-3 Producing Adenocarcinoma

Nuklearmedizin ◽

10.1055/s-0038-1632352 ◽

1998 ◽

Vol 37 (08) ◽

pp. 297-298 ◽

Cited By ~ 1

Author(s):

A. Özet ◽

A. Arpaci ◽

S. Kömiircü ◽

G. Üçkaya

Keyword(s):

Lung Adenocarcinoma ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Carbohydrate Antigen ◽

Beta Subunit ◽

Cancer Antigen ◽

First Report ◽

Primary Lung Adenocarcinoma ◽

Adenocarcinoma Of Lung

Summary50 years old man suffering from primary lung adenocarcinoma presented with high levels of both beta subunit human chorionic gonadotropin (βHCG) and cancer antigen 15-3 (CA 15-3) in the absence of elevated carcinoembrionic antigen (CEA), alfa fetoprotein (AFP) and carbohydrate antigen 19-9 (CA 19-9). Although βHCG or CA 15-3 high levels were reported in adenocarcinoma of lung, this is the first report of a patient with high levels of both markers.

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