Low-Level Vagus Nerve Stimulation Attenuates Myocardial Ischemic Reperfusion Injury by Antioxidative Stress and Antiapoptosis Reactions in Canines

2015 ◽  
Vol 27 (2) ◽  
pp. 224-231 ◽  
Author(s):  
MINGXIAN CHEN ◽  
XIAOYA ZHOU ◽  
LILEI YU ◽  
QIMING LIU ◽  
XIA SHENG ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Reperfusion Injury ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Ischemic Reperfusion Injury ◽  
Low Level ◽  
Ischemic Reperfusion ◽  
Antioxidative Stress

scholarly journals Vagus Nerve Stimulation Alleviates Hepatic Ischemia and Reperfusion Injury by Regulating Glutathione Production and Transformation

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Haoyang Xia ◽  
Zhongzhong Liu ◽  
Wenjin Liang ◽  
Xianpeng Zeng ◽  
Yi Yang ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Reperfusion Injury ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Hepatic Function ◽  
Glutathione Synthetase ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Hepatic Ischemia

Inflammation and oxidative stress are pivotal mechanisms for the pathogenesis of ischemia and reperfusion injury (IRI). Vagus nerve stimulation (VNS) may participate in maintaining oxidative homeostasis and response to external stimulus or injury. We investigated whether the in vivo VNS can protect the liver from IRI. In this study, hepatic IRI were induced by ligating the vessels supplying the left and middle lobes of the liver, which underwent 1 h occlusion followed with 24 h reperfusion. VNS was initiated 15 min after ischemia and continued 30 min. Hepatic function, histology, and apoptosis rates were evaluated after 24 h reperfusion. Compared with the IRI group, VNS significantly improved hepatic function. The protective effect was accompanied by a reduction in histological damage in the ischemic area, and the apoptosis rate of hepatocytes has considerable reduction. To find the underlying mechanism, proteomic analysis was performed and differential expression of glutathione synthetase (GSS) and glutathione S-transferase (GST) was observed. Subsequently, test results indicated that VNS upregulated the expression of mRNA and protein of GSS and GST. Meanwhile, VNS increased the plasma levels of glutathione and glutathione peroxidases. We found that VNS alleviated hepatic IRI by upregulating the antioxidant glutathione via the GSS/glutathione/GST signaling pathway.

The role of low-level vagus nerve stimulation in cardiac therapy

2019 ◽  
Vol 16 (8) ◽  
pp. 675-682 ◽  
Author(s):  
Yuhong Wang ◽  
Sunny S. Po ◽  
Benjamin J. Scherlag ◽  
Lilei Yu ◽  
Hong Jiang
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Low Level ◽  
Cardiac Therapy

scholarly journals Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes

2016 ◽  
Vol 126 (5) ◽  
pp. 1939-1952 ◽  
Author(s):  
Tsuyoshi Inoue ◽  
Chikara Abe ◽  
Sun-sang J. Sung ◽  
Stefan Moscalu ◽  
Jakub Jankowski ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Reperfusion Injury ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Kidney Ischemia

scholarly journals Continuous Low-Level Vagus Nerve Stimulation Reduces Stellate Ganglion Nerve Activity and Paroxysmal Atrial Tachyarrhythmias in Ambulatory Canines

Circulation ◽  
2011 ◽  
Vol 123 (20) ◽  
pp. 2204-2212 ◽  
Author(s):  
Mark J. Shen ◽  
Tetsuji Shinohara ◽  
Hyung-Wook Park ◽  
Kyle Frick ◽  
Daniel S. Ice ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Stellate Ganglion ◽  
Nerve Activity ◽  
Atrial Tachyarrhythmias ◽  
Low Level

Low-Level Vagus Nerve Stimulation Suppresses Post-Operative Atrial Fibrillation and Inflammation

2017 ◽  
Vol 3 (9) ◽  
pp. 929-938 ◽  
Author(s):  
Stavros Stavrakis ◽  
Mary Beth Humphrey ◽  
Benjamin Scherlag ◽  
Omer Iftikhar ◽  
Purvi Parwani ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Low Level ◽  
Post Operative Atrial Fibrillation

scholarly journals Low-Level Transcutaneous Electrical Vagus Nerve Stimulation Suppresses Atrial Fibrillation

2015 ◽  
Vol 65 (9) ◽  
pp. 867-875 ◽  
Author(s):  
Stavros Stavrakis ◽  
Mary Beth Humphrey ◽  
Benjamin J. Scherlag ◽  
Yanqing Hu ◽  
Warren M. Jackman ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Low Level
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