scholarly journals Vagus Nerve Stimulation Alleviates Hepatic Ischemia and Reperfusion Injury by Regulating Glutathione Production and Transformation

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Haoyang Xia ◽  
Zhongzhong Liu ◽  
Wenjin Liang ◽  
Xianpeng Zeng ◽  
Yi Yang ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Reperfusion Injury ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Hepatic Function ◽  
Glutathione Synthetase ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Hepatic Ischemia

Inflammation and oxidative stress are pivotal mechanisms for the pathogenesis of ischemia and reperfusion injury (IRI). Vagus nerve stimulation (VNS) may participate in maintaining oxidative homeostasis and response to external stimulus or injury. We investigated whether the in vivo VNS can protect the liver from IRI. In this study, hepatic IRI were induced by ligating the vessels supplying the left and middle lobes of the liver, which underwent 1 h occlusion followed with 24 h reperfusion. VNS was initiated 15 min after ischemia and continued 30 min. Hepatic function, histology, and apoptosis rates were evaluated after 24 h reperfusion. Compared with the IRI group, VNS significantly improved hepatic function. The protective effect was accompanied by a reduction in histological damage in the ischemic area, and the apoptosis rate of hepatocytes has considerable reduction. To find the underlying mechanism, proteomic analysis was performed and differential expression of glutathione synthetase (GSS) and glutathione S-transferase (GST) was observed. Subsequently, test results indicated that VNS upregulated the expression of mRNA and protein of GSS and GST. Meanwhile, VNS increased the plasma levels of glutathione and glutathione peroxidases. We found that VNS alleviated hepatic IRI by upregulating the antioxidant glutathione via the GSS/glutathione/GST signaling pathway.

Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning

Surgery ◽  
2006 ◽  
Vol 140 (5) ◽  
pp. 793-802 ◽  
Author(s):  
Tadashi Matsumoto ◽  
Kerri O’Malley ◽  
Philip A. Efron ◽  
Colette Burger ◽  
Priscilla F. McAuliffe ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemic Preconditioning ◽  
Interleukin 6 ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Hepatic Ischemia

scholarly journals Paneth cell-derived interleukin-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury

Hepatology ◽  
2011 ◽  
Vol 53 (5) ◽  
pp. 1662-1675 ◽  
Author(s):  
Sang Won Park ◽  
Mihwa Kim ◽  
Kevin M. Brown ◽  
Vivette D. D'Agati ◽  
H. Thomas Lee
Keyword(s):  
Reperfusion Injury ◽  
Paneth Cell ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Hepatic Ischemia ◽  
Multiorgan Dysfunction ◽  
Interleukin 17A

scholarly journals Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu

2013 ◽  
Vol 59 (5) ◽  
pp. 1094-1106 ◽  
Author(s):  
Carmen Peralta ◽  
Mónica B. Jiménez-Castro ◽  
Jordi Gracia-Sancho
Keyword(s):  
Reperfusion Injury ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Hepatic Ischemia

scholarly journals Evaluation of Indigo carmine on hepatic ischemia and reperfusion injury

2020 ◽  
Vol 35 (9) ◽  
Author(s):  
Eduardo Alexandre Rancan ◽  
Eloísa Ianes Frota ◽  
Tábata Marina Nóbrega de Freitas ◽  
Maria Cecília Jordani ◽  
Paulo Roberto Barbosa Évora ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Indigo Carmine ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Hepatic Ischemia

Airway neutral endopeptidase-like enzyme modulates tachykinin-induced bronchoconstriction in vivo

1988 ◽  
Vol 65 (6) ◽  
pp. 2585-2591 ◽  
Author(s):  
D. J. Dusser ◽  
E. Umeno ◽  
P. D. Graf ◽  
T. Djokic ◽  
D. B. Borson ◽  
...  
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Guinea Pigs ◽  
Vagus Nerve Stimulation ◽  
Neutral Endopeptidase ◽  
Base Line ◽  
Pulmonary Resistance

To determine whether neutral endopeptidase (NEP), also called enkephalinase (EC 3.4.24.11), modulates the effects of exogenous and endogenous tachykinins in vivo, we studied the effects of aerosolized phosphoramidon, a specific NEP inhibitor, on the responses to aerosolized substance P (SP) and on the atropine-resistant response to vagus nerve stimulation (10 V, 5 ms for 20 s) in guinea pigs. SP alone (10(-7) to 10(-4) M; each concentration, 7 breaths) caused no change in total pulmonary resistance (RL, P greater than 0.5). Phosphoramidon (10(-4) M, 90 breaths) caused no change either in base-line RL (P greater than 0.5) or in the response to aerosolized acetylcholine (P greater than 0.5). However, in the presence of phosphoramidon, SP (7 breaths) produced a concentration-dependent increase in RL at concentrations greater than or equal to 10(-5) M (P less than 0.001). Phosphoramidon (10(-7) to 10(-4) M; each concentration, 90 breaths) induced a concentration-dependent potentiation of SP-induced bronchoconstriction (10(-4) M, 7 breaths; P less than 0.01). Vagus nerve stimulation (0.5-3 Hz), in the presence of atropine, induced a frequency-dependent increase in RL (P less than 0.001). Phosphoramidon potentiated the atropine-resistant responses to vagus nerve stimulation (P less than 0.001) at frequencies greater than 0.5 Hz. The tachykinin antagonist [D-Arg1,D-Pro2,D-Trp7,9,Leu11]-substance P abolished the effects of phosphoramidon on the atropine-resistant response to vagus nerve stimulation (2 Hz, P less than 0.005). NEP-like activity in tracheal homogenates of guinea pig was inhibited by phosphoramidon with a concentration producing 50% inhibition of 5.3 +/- 0.8 nM.(ABSTRACT TRUNCATED AT 250 WORDS)

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