Management of periodontal disease in patients using calcium channel blockers - gingival overgrowth, prescribed medications, treatment responses and added treatment costs

2015 ◽  
Vol 42 (7) ◽  
pp. 640-646 ◽  
Author(s):  
Øystein Fardal ◽  
Henning Lygre
Keyword(s):  
Periodontal Disease ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Treatment Costs ◽  
Channel Blockers ◽  
Gingival Overgrowth ◽  
Treatment Responses

Treatment of calcium channel blocker-induced gingival overgrowth without modifying medication

2021 ◽  
Vol 14 (1) ◽  
pp. e238872 ◽  
Author(s):  
Satoru Morikawa ◽  
Mana Nasu ◽  
Yoko Miyashita ◽  
Taneaki Nakagawa
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Calcium Channel Blockers ◽  
Channel Blocker ◽  
Periodontal Treatment ◽  
Common Side Effect ◽  
Channel Blockers ◽  
Gingival Overgrowth ◽  
Old Japanese ◽  
Almost All

Gingival overgrowth is a common side effect of calcium channel blockers used in the treatment of cardiovascular diseases. While controversial, management includes discontinuing the calcium channel blocker. We report the case of a 66-year-old Japanese man with hypertension and type 2 diabetes mellitus who was diagnosed with severe periodontitis covering almost all the teeth. The patient had been on nifedipine (40 mg/day) and amlodipine (10 mg/day) medication for 5 years. With his physician’s consent, nifedipine was discontinued during his treatment for periodontitis, which consisted of oral hygiene instructions and scaling and root planing on all areas. Gingivectomy was performed on the areas of hard fibrous swelling. Nifedipine was resumed during periodontal treatment when the patient’s hypertension worsened. His periodontal scores improved when he resumed treatment. We report that significant improvement in gingival overgrowth can occur with basic periodontal treatment, surgery and sustained intensive follow-up without adjusting calcium channel blockers.

scholarly journals Amlodipine induced generalized gingival overgrowth: A clinical case

2021 ◽  
Vol 6 (2) ◽  
pp. 125-127
Author(s):  
Sayani Shome ◽  
Amit De ◽  
Arup Ghosh ◽  
Ankita Saraf
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Geriatric Patient ◽  
Clinical Case ◽  
Gingival Tissue ◽  
Channel Blockers ◽  
Unique Case ◽  
Gingival Overgrowth ◽  
Management Protocol ◽  
Gingival Enlargement

Calcium channel blockers (CCB) like Amlodipine, Nifedipine etc are widely used as anti-hypertensive drugs which on chronic intake shows gingival enlargement. It is an iatrogenic response of gingival tissue to these drugs along with other category of medications like antiepileptics and immunosuppressants. A unique case of long standing gingival overgrowth due to prolonged usage of CCB such as Amlodipine in a geriatric patient are portrayed herewith clinical, histopathological attributes and management protocol.

Influence of 3 calcium channel blockers on gingival overgrowth in a population of severe refractory hypertensive patients

2018 ◽  
Vol 53 (5) ◽  
pp. 721-726 ◽  
Author(s):  
F. Vidal ◽  
R. C. de Souza ◽  
D. C. Ferreira ◽  
R. G. Fischer ◽  
L. S. Gonçalves
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Hypertensive Patients ◽  
Gingival Overgrowth

scholarly journals Cyclosporine A and amlodipine induced gingival overgrowth in a kidney transplant recipient: case presentation with literature review

2019 ◽  
Vol 12 (5) ◽  
pp. e229587 ◽  
Author(s):  
Tarun Nanda ◽  
Baljeet Singh ◽  
Parul Sharma ◽  
Karandeep Singh Arora
Keyword(s):  
Calcium Channel ◽  
Kidney Transplant ◽  
Cyclosporine A ◽  
Calcium Channel Blockers ◽  
Kidney Transplant Recipient ◽  
Kidney Transplant Patient ◽  
Channel Blockers ◽  
Drug Induced ◽  
Gingival Overgrowth ◽  
Gingival Enlargement

Drug-induced gingival overgrowth is a condition caused by side effects of treatment with one of three types of drugs: phenytoin (used in epilepsy treatment), cyclosporine A (used in transplantology after allogenic organ transplants) and calcium channel blockers (used in the treatment of hypertension). Gingival overgrowth leads to inflammation within the gums and periodontium and can amplify the existing periodontal disease leading to tooth loss. Patients who have undergone kidney transplant are given immunosuppressants to prevent transplant rejection and mostly it is accompanied with calcium channel blockers to treat hypertension associated with kidney transplant. This article reports a case of recent gingival enlargement associated with cyclosporine A and amlodipine given to a kidney transplant patient from the past 11 years.

Microarray and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients

2011 ◽  
Vol 56 (3) ◽  
pp. 277-284 ◽  
Author(s):  
Taro Shimizu ◽  
Takehiko Kubota ◽  
Naohiro Nakasone ◽  
Daisuke Abe ◽  
Toshiya Morozumi ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Rt Pcr ◽  
Gingival Overgrowth

Prevalence of Gingival Overgrowth Induced by Calcium Channel Blockers: A Community-Based Study

1999 ◽  
Vol 70 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Janice S. Ellis ◽  
Robin A. Seymour ◽  
James G. Steele ◽  
Pauline Robertson ◽  
Tim J. Butler ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Community Based ◽  
Gingival Overgrowth

Gingival Overgrowth in Renal Transplant Subjects Medicated With Tacrolimus in the Absence of Calcium Channel Blockers

2008 ◽  
Vol 85 (2) ◽  
pp. 232-236 ◽  
Author(s):  
Erika S. Cezário ◽  
Luís O. M. Cota ◽  
Sérgio D. Ferreira ◽  
Fernanda M. Siqueira ◽  
Rodrigo V. Soares ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Gingival Overgrowth

EFFECTIVENESS OF NON-SURGICAL PERIODONTAL THERAPY ON AMLODIPINE INDUCED GINGIVAL ENLARGEMENT: A CASE REPORT

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dagar Mona ◽  
Kataria Prerna
Keyword(s):  
Case Report ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Normal State ◽  
Periodontal Therapy ◽  
Channel Blockers ◽  
Scaling And Root Planing ◽  
Drug Induced ◽  
Gingival Overgrowth ◽  
Gingival Enlargement

Gingival enlargement, [sometimes abbreviated to GO (gingival overgrowth)] is an increase in the size of the gingiva. It is a common feature of gingival disease. Gingival enlargement is a well known side-effect of drugs like anticonvulsants, calcium channel blockers and immunosuppressant. A case of amlodipine induced gingival enlargement was reported and after drug substitution when the patient was treated non-surgically (scaling and root planing), the enlargement subsides to a normal state which suggested the effectiveness of non-surgical periodontal therapy in the treatment of drug induced gingival enlargement. Keywords: Anticonvulsants, Immunosuppressants, Calcium channel blockers, gingival enlargement

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