EFFECTIVENESS OF NON-SURGICAL PERIODONTAL THERAPY ON AMLODIPINE INDUCED GINGIVAL ENLARGEMENT: A CASE REPORT

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dagar Mona ◽  
Kataria Prerna
Keyword(s):  
Case Report ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Normal State ◽  
Periodontal Therapy ◽  
Channel Blockers ◽  
Scaling And Root Planing ◽  
Drug Induced ◽  
Gingival Overgrowth ◽  
Gingival Enlargement

Gingival enlargement, [sometimes abbreviated to GO (gingival overgrowth)] is an increase in the size of the gingiva. It is a common feature of gingival disease. Gingival enlargement is a well known side-effect of drugs like anticonvulsants, calcium channel blockers and immunosuppressant. A case of amlodipine induced gingival enlargement was reported and after drug substitution when the patient was treated non-surgically (scaling and root planing), the enlargement subsides to a normal state which suggested the effectiveness of non-surgical periodontal therapy in the treatment of drug induced gingival enlargement. Keywords: Anticonvulsants, Immunosuppressants, Calcium channel blockers, gingival enlargement

scholarly journals Cyclosporine A and amlodipine induced gingival overgrowth in a kidney transplant recipient: case presentation with literature review

2019 ◽  
Vol 12 (5) ◽  
pp. e229587 ◽  
Author(s):  
Tarun Nanda ◽  
Baljeet Singh ◽  
Parul Sharma ◽  
Karandeep Singh Arora
Keyword(s):  
Calcium Channel ◽  
Kidney Transplant ◽  
Cyclosporine A ◽  
Calcium Channel Blockers ◽  
Kidney Transplant Recipient ◽  
Kidney Transplant Patient ◽  
Channel Blockers ◽  
Drug Induced ◽  
Gingival Overgrowth ◽  
Gingival Enlargement

Drug-induced gingival overgrowth is a condition caused by side effects of treatment with one of three types of drugs: phenytoin (used in epilepsy treatment), cyclosporine A (used in transplantology after allogenic organ transplants) and calcium channel blockers (used in the treatment of hypertension). Gingival overgrowth leads to inflammation within the gums and periodontium and can amplify the existing periodontal disease leading to tooth loss. Patients who have undergone kidney transplant are given immunosuppressants to prevent transplant rejection and mostly it is accompanied with calcium channel blockers to treat hypertension associated with kidney transplant. This article reports a case of recent gingival enlargement associated with cyclosporine A and amlodipine given to a kidney transplant patient from the past 11 years.

scholarly journals Amlodipine induced generalized gingival overgrowth: A clinical case

2021 ◽  
Vol 6 (2) ◽  
pp. 125-127
Author(s):  
Sayani Shome ◽  
Amit De ◽  
Arup Ghosh ◽  
Ankita Saraf
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Geriatric Patient ◽  
Clinical Case ◽  
Gingival Tissue ◽  
Channel Blockers ◽  
Unique Case ◽  
Gingival Overgrowth ◽  
Management Protocol ◽  
Gingival Enlargement

Calcium channel blockers (CCB) like Amlodipine, Nifedipine etc are widely used as anti-hypertensive drugs which on chronic intake shows gingival enlargement. It is an iatrogenic response of gingival tissue to these drugs along with other category of medications like antiepileptics and immunosuppressants. A unique case of long standing gingival overgrowth due to prolonged usage of CCB such as Amlodipine in a geriatric patient are portrayed herewith clinical, histopathological attributes and management protocol.

scholarly journals AMLODIPINE RELATED GINGIVAL OVERGROWTH IN A PATIENT WITH ASOCIATED AUTOSOMAL POLYCYSTIC KIDNEY DISEASE

2015 ◽  
Vol 61 (1) ◽  
pp. 91-95
Author(s):  
Fidan Bahtiar Ismail ◽  
◽  
Horia Traian Dumitriu ◽  
Anca Silvia Dumitriu ◽  
Gener Ismail ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Calcium Channel ◽  
Polycystic Kidney Disease ◽  
Drug Regimen ◽  
Periodontal Therapy ◽  
Channel Blockers ◽  
Polycystic Kidney ◽  
Gingival Overgrowth ◽  
Gingival Enlargement ◽  
Autosomal Dominant Polycystic Kidney

Background. The paper describes the case of a 62 years non-smoking male patient who was referred to the Department of Periodontology, “Carol Davila” University of Medicine and Pharmacy, complaining of gingival overgrowth. The patient’s medical history revealed that he suffers from autosomal dominant polycystic kidney disease chronic renal failure and hypertension; the patient was under treatment with amlodipine, a calcium channel blocker for 18 months. Case presentation. The patient underwent cause-related periodontal therapy and flap surgery in areas where only partial resolution of the gingival overgrowth was obtained after completion of initial phase therapy; amlodipine was not substituted because of medical reasons. Results. We obtained complete resolution of the gingival enlargement, even without any change in the causative drug regimen; the patient was placed in a maintenance program, with regular appointments at 3 months; he successfully managed to maintain periodontal and oral health. Conclusions. If possible, all patients who are about to receive calcium channel blockers, should have a detailed periodontal assessment performed and if any periodontal disease discovered, treated properly. In case of established gingival overgrowth, non-surgical and/or surgical periodontal therapy could induce partial or complete remission of enlargement. Change of medication is also an option.

scholarly journals Laser Therapy In Drug Induced Gingival Hyperplasia- A Case Report

2021 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Case Report ◽  
Calcium Channel ◽  
Laser Therapy ◽  
Calcium Channel Blockers ◽  
Treatment Modalities ◽  
Personal Satisfaction ◽  
Channel Blockers ◽  
Gingival Hyperplasia ◽  
Bacterial Burden ◽  
Drug Induced

Gingival excess is related with various components including innate infections, hormonal unsettling influences, helpless oral cleanliness condition, aggravation, neoplastic conditions, and unfavorable medication responses including anticonvulsants, calcium channel blockers, and immunosuppressants. This can have an inconvenient impact on the personal satisfaction and furthermore on high oral bacterial burden brought about by plaqueretentive regions. Different treatment modalities incorporate both careful (gingivectomy, periodontal fold, electrosurgery, and laser extraction) and nonsurgical methodologies. This case report reveals the treatment of drug induced gingival hyperplasia with laser

scholarly journals A rare case of accelerated gingival overgrowth with high dose amlodipine therapy

2021 ◽  
Vol 2 (1) ◽  
pp. 39-41
Author(s):  
Rakesh B M ◽  
Sahithi Sharma ◽  
Chandana K H
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Rare Case ◽  
Immunosuppressive Drugs ◽  
High Dose ◽  
Channel Blockers ◽  
Gingival Hyperplasia ◽  
Limited Evidence ◽  
Drug Induced ◽  
Gingival Overgrowth

Introduction: Gingival overgrowth represents an over-exuberant response to a variety of local and systemic conditions. Certain anticonvulsants, immunosuppressive drugs, and a number of calcium channel blockers have been shown to produce similar gingival overgrowth in susceptible patients. Case report: We report a case of accelerated drug-induced gingival overgrowth in a 60-year-old hypertensive patient taking amlodipine at a dose of 10 mg. Conclusions: Among the calcium channel blockers, nifedipine is most frequently associated with gingival overgrowth.  Whereas, there is limited evidence of amlodipine-induced gingival hyperplasia.

scholarly journals Phenytoin-Induced Gingival Overgrowth: A Review of the Molecular, Immune, and Inflammatory Features

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Jôice Dias Corrêa ◽  
Celso Martins Queiroz-Junior ◽  
José Eustáquio Costa ◽  
Antônio Lúcio Teixeira ◽  
Tarcilia Aparecida Silva
Keyword(s):  
Extracellular Matrix ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Side Effect ◽  
Channel Blockers ◽  
Connective Tissues ◽  
Drug Induced ◽  
Gingival Overgrowth ◽  
Matrix Metabolism

Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth.

scholarly journals Gingival Enlargement in Antihypertensive Medication

2009 ◽  
Vol 48 (174) ◽  
pp. 149-52 ◽  
Author(s):  
Shaili Pradhan ◽  
P Mishra
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Antihypertensive Medication ◽  
Channel Blocker ◽  
Antihypertensive Agents ◽  
Channel Blockers ◽  
Drug Induced ◽  
Probing Depth ◽  
Increased Risk ◽  
Gingival Enlargement

Introduction: Drug-induced gingival enlargement is a well documented side effect with the use of phenytoin, cyclosporine and calcium channel blockers. The prevalence of gingival enlargement induced by calcium channel blockers is uncertain. Several studies show confl icting results ranging from 20% to 83%. This study was conducted to determine the prevalence of gingival enlargement in patients taking antihypertensive medication. Methods: All consecutive patients on antihypertensive agents attending the Dental OPD were studied. The prevalence of drug induced gingival enlargement was determined. The periodontal condition of all subjects were assessed including plaque index and probing depth. Results: Total 81.2% of subjects taking antihypertensive were seen to have signifi cant enlargement. Among them 71.1% were taking calcium channel blocker, 21.5% were taking ACE Inhibitors, and 7.4% were taking β- blockers. Conclusions:Patients taking antihypertensive agents are at increased risk for gingival enlargement and infl ammation is an important cofactor for the expression of this effect.Key Words: anti-hypertensive drugs, gingival enlargement

scholarly journals Gingival enlargement induced by dihydropyridine calcium channel blockers in a young child

2014 ◽  
Vol 2014 (sep08 1) ◽  
pp. bcr2014206761-bcr2014206761
Author(s):  
J. Miranda-Rius ◽  
L. Brunet-Llobet ◽  
E. Lahor-Soler ◽  
A. Ramirez-Ramiz
Keyword(s):  
Young Child ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Gingival Enlargement

scholarly journals Drug-Induced Gingival Overgrowth in an 8-Year-Old Girl: A Case Report

2021 ◽  
Vol 13 (3) ◽  
pp. 109-112
Author(s):  
Parviz Torkzaban ◽  
Amir Talaie
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Immunological Tolerance ◽  
Systemic Autoimmune Disease ◽  
Channel Blockers ◽  
Systemic Lupus ◽  
Drug Induced ◽  
Gingival Overgrowth

Systemic lupus erythematosus is a systemic autoimmune disease that involves multi organs. Genetic, endocrine, immunological, and environmental factors influence the loss of immunological tolerance against self-antigens leading to the formation of pathogenic autoantibodies that cause tissue damage through multiple mechanisms. The gingival overgrowth can be caused by three factors: noninflammatory, hyperplastic reaction to the medication; chronic inflammatory hyperplasia; or a combined enlargement due to chronic inflammation and drug-induced hyperplasia. Drug-Induced Gingival Overgrowth is associated with the use of three major classes of drugs, namely anticonvulsants, calcium channel blockers, and immunosuppressants. Due to recent indications for these drugs, their use continues to grow.

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