Allergic contact dermatitis caused by a glucose monitoring system: an emerging side‐effect of diabetes medical devices

2020 ◽  
Vol 34 (5) ◽  
Author(s):  
M. Tramontana ◽  
K. Hansel ◽  
L. Bianchi ◽  
D. Agostinelli ◽  
L. Stingeni
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Monitoring System ◽  
Medical Devices ◽  
Side Effect ◽  
Glucose Monitoring ◽  
Allergic Contact

scholarly journals Further Evidence of Severe Allergic Contact Dermatitis From Isobornyl Acrylate While Using a Continuous Glucose Monitoring System

2018 ◽  
Vol 12 (3) ◽  
pp. 630-633 ◽  
Author(s):  
Stefanie Kamann ◽  
Olivier Aerts ◽  
Lutz Heinemann
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Monitoring System ◽  
Continuous Glucose Monitoring ◽  
Glucose Sensor ◽  
Skin Irritation ◽  
Glucose Monitoring ◽  
Gas Chromatography Mass Spectrometry ◽  
Skin Reactions ◽  
Allergic Contact

In the past decade, new diabetes technologies, including continuous glucose monitoring (CGM) systems, support patients with diabetes in their daily struggle with achieving a good glucose control. However, shortly after the first CGM systems appeared on the market, also the first concerns about adverse skin reactions were raised. Most patients claimed to suffer from (sometimes severe) skin irritation, or even allergy, which they related to the (acrylate-based) adhesive part of the device. For a long time the actual substance that caused these skin reactions with, for example, the Flash Glucose Monitoring system (iscCGM; Freestyle® Libre) could not be identified; however, recently Belgian and Swedish dermatologists reported that the majority of their patients that have developed a contact-allergic while using iscCGM react sensitively to a specific acrylate, that is, isobornyl acrylate (IBOA). Subsequently they showed by means of gas chromatography-mass spectrometry that this substance is present in the case of the glucose sensor attached by an adhesive to the skin. We report three additional cases from Germany, including a 10-year-old boy, suffering from severe allergic contact dermatitis to IBOA.

Allergic contact dermatitis caused by isobornyl acrylate in a young diabetic patient using a continous glucose monitoring system (Freestyle Libre)

2018 ◽  
Vol 79 (5) ◽  
pp. 320-321 ◽  
Author(s):  
Monica Corazza ◽  
Valeria Scuderi ◽  
Dario Musmeci ◽  
Caterina Foti ◽  
Paolo Romita ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Diabetic Patient ◽  
Allergic Contact Dermatitis ◽  
Monitoring System ◽  
Glucose Monitoring ◽  
Freestyle Libre ◽  
Allergic Contact

Allergic contact dermatitis from potassium sorbate and sorbic acid in topical pharmaceuticals and medical devices

2021 ◽  
Author(s):  
Ella Dendooven ◽  
Stefan Kerre ◽  
Kenn Foubert ◽  
Luc Pieters ◽  
Julien Lambert ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Medical Devices ◽  
Sorbic Acid ◽  
Potassium Sorbate ◽  
Allergic Contact

Patch testing and diagnosis when suspecting allergic contact dermatitis from medical devices

2020 ◽  
Vol 83 (4) ◽  
pp. 333-335
Author(s):  
Josefin Ulriksdotter ◽  
Martin Mowitz ◽  
Cecilia Svedman ◽  
Magnus Bruze
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Medical Devices ◽  
Patch Testing ◽  
Allergic Contact

Allergic contact dermatitis and diabetes medical devices: 2 clinical cases

2018 ◽  
Vol 79 (2) ◽  
pp. 115-117 ◽  
Author(s):  
Stefano Passanisi ◽  
Fortunato Lombardo ◽  
Andrea Barbalace ◽  
Lucia Caminiti ◽  
Ilenia Panasiti ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Medical Devices ◽  
Allergic Contact ◽  
Clinical Cases

Allergic contact dermatitis by isobornyl acrylate in glucose monitoring devices: Report of two cases

2019 ◽  
Vol 81 (3) ◽  
pp. 219-220 ◽  
Author(s):  
Ignacio Jáuregui ◽  
Javier Sánchez ◽  
Aritza Segurola ◽  
Cristina Galán ◽  
Yolanda Seras ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Glucose Monitoring ◽  
Allergic Contact ◽  
Monitoring Devices

scholarly journals Allergic contact dermatitis to luliconazole: An uncommon side effect of a commonly used drug

2020 ◽  
Vol 6 (1) ◽  
pp. 47
Author(s):  
Trashita Hassanandani ◽  
Anil Panda ◽  
BikashRanjan Kar
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Side Effect ◽  
Allergic Contact

scholarly journals Acquired Leukoderma in a Patient with Allergic Contact Dermatitis to FreeStyle Libre®

2020 ◽  
Vol 78 (4) ◽  
pp. 381-384
Author(s):  
C. S. Queirós ◽  
M. I. Alexandre ◽  
P. M. Garrido ◽  
L. Soares de Almeida ◽  
T. Correia ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Medical Devices ◽  
Glucose Sensor ◽  
Diabetes Mellitus Type 1 ◽  
The Past ◽  
Freestyle Libre ◽  
Allergic Contact

In the past few years, the glucose sensor FreeStyle Libre® has been associated with several cases of allergic contact dermatitis. The allergen responsible for most of these cases is isobornyl acrylate, a substance present within the sensor that migrates through the adhesive, thereby reaching the skin. Acquired leukoderma, which may occur in an area previously affected by allergic contact dermatitis, has been described in several medical devices with adhesives. However, until the present, only one case of leukoderma induced by allergic contact dermatitis to FreeStyle Libre® has been described. We report the case of a 41-year-old woman with diabetes mellitus type 1, who developed leukoderma in association with allergic contact dermatitis to this glucose sensor.

scholarly journals Usage of Hydrocolloid-Based Plasters in Patients Who Have Developed Allergic Contact Dermatitis to Isobornyl Acrylate While Using Continuous Glucose Monitoring Systems

2019 ◽  
Vol 14 (3) ◽  
pp. 582-585 ◽  
Author(s):  
Stefanie Kamann ◽  
Lutz Heinemann ◽  
Eva Oppel
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Major Allergen ◽  
Skin Reactions ◽  
Self Monitoring ◽  
Freestyle Libre ◽  
Patients With Diabetes ◽  
Allergic Contact

Background: Continuous glucose monitoring (CGM) systems replace more and more capillary self-monitoring of blood glucose by patients with diabetes. However, at least a subset of patients experience adverse skin reactions such as severe allergic contact dermatitis (ACD) after prolonged usage of CGM systems. A major allergen isobornyl acrylate (IBOA) has been identified recently. Objectives: After developing an ACD, patients have difficulties in continuing the usage of their CGM system (and also of, eg, certain patch pumps). Most of such patients look for possibilities to continue the usage of, eg, a CGM system that requires intermittent scanning (iscCGM, Freestyle Libre). Patients and Methods: Eight patients with a known ACD were supplied with different hydrocolloid-based plasters ( n = 5 with Hansaplast blister plaster, n = 2 with Cutimed Hydro B from BSN, and n = 1 with Stomahesive baseplate from Convatec). They attached these plasters to their skin underneath their iscCGM system. Results: All patients were able to continue the usage of this iscCGM system when using such plasters. Conclusion: Patients with ACD benefit from the usage of such plasters; however, some limitations have to be acknowledged.

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