Treatment of nail psoriasis with calcipotriol/betamethasone dipropionate foam versus pulse dye laser: an unblinded, intra‐patient, left‐to‐right prospective study

Background and Objective. Psoriasis is a common chronic inflammatory skin disorder affecting any age and gender. The clinical presentation of the nail disease depends on the location of the pathology: nail bed or nail matrix. We aimed to compare the therapeutic effects of triamcinolone acetonide iontophoresis (TI) and topical calcipotriol/betamethasone dipropionate in the nail bed and nail matrix involvements of psoriasis using Nail Psoriasis Severity Index (NAPSI). Materials and Methods. In the present bilateral comparison clinical trial, sixteen patients with clinical diagnosis of nail psoriasis were enrolled and randomized to receive six monthly TI treatment sessions either on their right or on the left hand target nails and daily application of topical calcipotriol/betamethasone dipropionate for six months on their other hand. Clinical efficacy was evaluated according to target nails NAPSI before and after the treatment. Wilcoxon sign-rank test and repeated measures ANOVA were used to compare the efficacy of the treatments. Results. The results did not show any difference between the therapeutic effects of TI and topical calcipotriol/betamethasone dipropionate regarding the nail bed score (P value = .356), matrix score (P value = .137), and total NAPSI (P-value = .098). Conclusion. Monthly TI has an equal efficacy compared to daily topical calcipotriol/betamethasone dipropionate. It can be used as a safe, easy, and compliant treatment for nail psoriasis. This study is registered under IRCT2017050233778N1.

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Treatment of nail psoriasis with Pulse Dye Laser plus calcipotriol betametasona gel vs. Nd:YAG plus calcipotriol betamethasone gel: An intrapatient left-to-right controlled study

Actas Dermo-Sifiliográficas ◽

10.1016/j.ad.2016.09.009 ◽

2017 ◽

Vol 108 (2) ◽

pp. 140-144 ◽

Cited By ~ 11

Author(s):

L.C. Arango-Duque ◽

M. Roncero-Riesco ◽

T. Usero Bárcena ◽

I. Palacios Álvarez ◽

E. Fernández López

Keyword(s):

Dye Laser ◽

Controlled Study ◽

Nail Psoriasis ◽

Calcipotriol Betamethasone

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Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment

Journal of Clinical Medicine ◽

10.3390/jcm10235589 ◽

2021 ◽

Vol 10 (23) ◽

pp. 5589

Author(s):

Lidia Rudnicka ◽

Małgorzata Olszewska ◽

Mohamad Goldust ◽

Anna Waśkiel-Burnat ◽

Olga Warszawik-Hendzel ◽

...

Keyword(s):

Systemic Treatment ◽

Common Adverse Effect ◽

Betamethasone Dipropionate ◽

Application Site ◽

Lower Probability ◽

Efficacy And Safety ◽

Nail Psoriasis ◽

Scalp Psoriasis ◽

Calcipotriol Betamethasone

Preparations containing calcipotriol combined with betamethasone dipropionate (in the forms of ointment, gel, and foam) are available for the topical treatment of psoriasis. This review summarizes the differences in the efficacy and safety of these formulations, as well as the preferences of patients with various forms of psoriasis (plaque, scalp, and nail psoriasis). It has been documented that foams provide higher bioavailability, resulting in increased efficacy in plaque psoriasis compared to ointments and gels. Gels or foams are preferred by patients for their different practical qualities (e.g., gels for “easy application”, and foams for “immediate relief”). The available data indicate that ointments may be the most effective formulation in nail psoriasis, and gels are preferred by patients with scalp psoriasis because of their cosmetic features. Treatment with a foam formulation is associated with a lower number of medical appointments compared to treatment with an ointment and with a lower probability of developing indications for systemic treatment. The safety profiles of foams, ointments, and gels are comparable, with the most common adverse effect being pruritus at the application site (in 5.8% of the patients). A long-term proactive maintenance therapy markedly reduces the number of relapses and is likely to close the gap between topical and systemic treatment in psoriasis.

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