Simultaneous Rp-Hplc Method For Determination Of Betamethasone Dipropionate And Tolnaftate In Combined Semisolid Formulation

A new RP-HPLC method was developed for selective and simultaneous determination of betamethasone dipropionate and tolnaftate in combined semisolid formulation containing other components. Further, the proposed method was validated for linearity, precision (system precision, method precision, intermediate or inter-day precision), accuracy, stability in analytical solution, robustness or system suitability and ruggedness. The developed method exhibited the best results in terms of the aforesaid validation parameters. The other components and additives did not interfere in their determinations. The method was found to be selective, simple, economical, accurate, reproducible, rapid and reliable for routine estimation purpose of these drugs in combined semisolid formulations.

AVALIAÇÃO DOS EFEITOS ADVERSOS DO COMPOSTO MEDICAMENTOSO FOSFATO DE SÓDIO DE BETAMETASONA E DIPROPIONATO DE BETAMETASONA: UMA REVISÃO INTEGRATIVA

Introdução: O composto medicamentoso formado por fosfato de sódio de betametasona (BSP) e dipropionato de betametasona (BDP), glicocorticoides (GC) sintéticos de ação rápida e prolongada, respectivamente, é vastamente utilizado em diversas afecções inflamatórias e alérgicas agudas ou crônicas. Contudo, o uso prolongado deve ser cauteloso, pois embora possua ampla eficácia, efeitos adversos podem ser inevitáveis e permanentes. Objetivo: Avaliar a ocorrência de efeitos adversos decorrentes do uso do composto medicamentoso BSP/BDP. Metodologia: Revisão integrativa com prospecção de artigos pelo PUBMED a partir da palavra-chave: “Betamethasone Dipropionate andBetamethasone Disodium Phosphate” (27 artigos); após exclusão, foram lidos 18 artigos, consensualmente, pelos autores. Resultados e discussão: O composto BSP/BDP está disponível na proporção 5mg/2mg em cada milímetro injetável intramuscular, apresentando ações terapêuticas anti-inflamatórias e antialérgicas. Diferentes estudos apontam importantes resoluções clínicas em doenças como osteoartrite, tendinite, pseudolinfoma cutâneo, miosite, hemangioma, lúpus eritematoso sistêmico, queloide e em outras diferentes doenças autoimunes, musculares e sistêmicas. Contudo, seu uso prolongado pode suprimir o eixo hipotálamo-hipófise-adrenal e comprometer a regulação endógena do cortisol, o que foi demonstrado em estudo recente, registrando-se que a injeção intra-articular do composto medicamentoso para o tratamento de osteoartrite resultou em insuficiência adrenal secundária em 30% dos pacientes. Paralelamente, pesquisadores relataram que 12,3% dos pacientes com hemangioma infantil e que fez uso do BSP/BDP apresentaram atrofia local, úlcera localizada e algumas manifestações semelhantes a Cushing como efeito adverso do composto BSP/BDP. Em outro estudo clínico, observou-se um aumento da glicemia em todos os pacientes com diabetes tipo 2 controlada, submetidos ao tratamento de osteoartrite. Estes efeitos adversos podem ser decorrentes da ação prolongada do BDP, principalmente, quando dose e intervalo entre a administração medicamentosa são ultrapassados. Conclusão: O composto BSP/BDP mostra ser eficaz no tratamento de diversas inflamações e doenças autoimunes, porém alguns pacientes podem apresentar efeitos adversos graves em curto ou longo prazo e deve-se ter cautela quando administrado naqueles com diabetes.

Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment

Preparations containing calcipotriol combined with betamethasone dipropionate (in the forms of ointment, gel, and foam) are available for the topical treatment of psoriasis. This review summarizes the differences in the efficacy and safety of these formulations, as well as the preferences of patients with various forms of psoriasis (plaque, scalp, and nail psoriasis). It has been documented that foams provide higher bioavailability, resulting in increased efficacy in plaque psoriasis compared to ointments and gels. Gels or foams are preferred by patients for their different practical qualities (e.g., gels for “easy application”, and foams for “immediate relief”). The available data indicate that ointments may be the most effective formulation in nail psoriasis, and gels are preferred by patients with scalp psoriasis because of their cosmetic features. Treatment with a foam formulation is associated with a lower number of medical appointments compared to treatment with an ointment and with a lower probability of developing indications for systemic treatment. The safety profiles of foams, ointments, and gels are comparable, with the most common adverse effect being pruritus at the application site (in 5.8% of the patients). A long-term proactive maintenance therapy markedly reduces the number of relapses and is likely to close the gap between topical and systemic treatment in psoriasis.

Calcipotriene 0.005%/Betamethasone Dipropionate 0.064% Foam as a Treatment for Nail Psoriasis

Combination topical corticosteroids and vitamin D analog treatments for nail psoriasis are widely used in cream and ointment vehicles, but patients may prefer a foam vehicle due to ease of application and favorable cosmetic appearance. Calcipotriene 0.005%/betamethasone dipropionate 0.064% (Cal/BD) aerosol foam is an FDA approved therapy for plaque psoriasis, but may also be an effective treatment for nail psoriasis in a novel aerosol foam. We present a case series of 3 patients with mild to moderate nail psoriasis who responded positively to treatment with Cal/BD aerosol foam applied 1-2 times daily to affected nails for at least 6 weeks. Reduction of nail plate surface abnormalities and a decrease in inflammation of the nail folds were assessed with clinical evaluation and dermoscopy, and documented with serial photography. While further research on the efficacy and safety of Cal/BD aerosol foam as a treatment for nail psoriasis is needed, this report suggests its potential as a combination topical vitamin D analogue and high potency steroid in a foam vehicle.