Multiple recurrent cutaneous masses in a cownose ray ( Rhinoptera bonasus ) with progression from benign lesions to high‐grade carcinoma

2019 ◽  
Vol 42 (11) ◽  
pp. 1623-1627 ◽  
Author(s):  
Bryan S. Vorbach ◽  
Lauren B. Peiffer ◽  
Leigh A. Clayton ◽  
Lisa M. Mangus
Keyword(s):  
High Grade ◽  
Benign Lesions ◽  
Cownose Ray ◽  
Rhinoptera Bonasus ◽  
High Grade Carcinoma

Immunoexpression of PAX 8 in endometrial cancer: Relation to high grade carcinoma and p53

2011 ◽  
Vol 71 (05) ◽  
Author(s):  
AH Brunner ◽  
P Riss ◽  
G Heinze ◽  
E Meltzow ◽  
H Brustmann
Keyword(s):  
Endometrial Cancer ◽  
High Grade ◽  
High Grade Carcinoma

Patterns in Immunohistochemical Usage in Extended Core Prostate Biopsies: Comparisons Among Genitourinary Pathologists and Nongenitourinary Pathologists

2013 ◽  
Vol 137 (11) ◽  
pp. 1630-1634 ◽  
Author(s):  
Anna Plourde ◽  
Alden Gross ◽  
Zhong Jiang ◽  
Christopher L. Owens
Keyword(s):  
Perineural Invasion ◽  
Gleason Grade ◽  
High Grade ◽  
Benign Lesions ◽  
Billing Data ◽  
Disease Extent ◽  
Bilateral Disease ◽  
Prostate Biopsies ◽  
Difficult Cases ◽  
Extent Of Disease

Context.—Immunohistochemical (IHC) stains have known utility in prostate biopsies and are widely used to augment routine staining in difficult cases. Patterns in IHC utilization and differences based on pathologist training and experience is understudied in the peer-reviewed literature. Objectives.—To compare the rates of IHC usage between specialized (genitourinary; [GU]) and nonspecialized (non-GU) pathologists in extended core prostate biopsies (ECPBs) and the effects of diagnosis; and in cancer cases Gleason grade, disease extent, and perineural invasion on the rate. Design.—Consecutive ECPBs from 2009–2011 were identified and billing data were used to determine the number of biopsies and IHC stains per case. Diagnoses were mapped and in cancer cases, Gleason grade, extent of disease, and perineural invasion were recorded. Pathologists were classified as GU or non-GU on the basis of training and experience. Results.—A total of 618 ECPBs were included in the study. Genitourinary pathologists ordered significantly fewer IHC tests per case and per biopsy than non-GU pathologists. The rate of ordering was most disparate for biopsies of cancerous and benign lesions. For biopsies of cancerous lesions, high-grade cancer, bilateral disease, and perineural invasion decreased the rate of ordering in both groups. In cancer cases, GU pathologists ordered significantly fewer stain tests for highest Gleason grade of 3 + 3 = 6, for patients with focal disease and for patients with multiple positive bilateral cores. The effect of the various predictors on IHC ordering rates was similar in both groups. Conclusions.—Genitourinary pathologists ordered significantly fewer IHC stain tests than non-GU pathologists in ECPBs. Guidelines to define when IHC workup is necessary and not necessary may be helpful to guide workups.

scholarly journals Redefining Stage I Endometrial Cancer: Incorporating Histology, a Binary Grading System, Myometrial Invasion, and Lymph Node Assessment

2013 ◽  
Vol 23 (9) ◽  
pp. 1620-1628 ◽  
Author(s):  
Joyce N. Barlin ◽  
Robert A. Soslow ◽  
Megan Lutz ◽  
Qin C. Zhou ◽  
Caryn M. St. Clair ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Myometrial Invasion ◽  
Staging System ◽  
Stage I ◽  
Low Grade ◽  
List Type ◽  
High Grade ◽  
High Grade Carcinoma ◽  
Concordance Probability ◽  
Grade 3

ObjectiveWe propose a new staging system for stage I endometrial cancer and compare its performance to the 1988 and 2009 International Federation of Gynecology and Obstetrics (FIGO) systems.MethodsWe analyzed patients with 1988 FIGO stage I endometrial cancer from January 1993 to August 2011. Low-grade carcinoma consisted of endometrioid grade 1 to grade 2 lesions. High-grade carcinoma consisted of endometrioid grade 3 or nonendometrioid carcinomas (serous, clear cell, and carcinosarcoma). The proposed system is as follows:IA. Low-grade carcinoma with less than half myometrial invasionIA1: Negative nodesIA2: No nodes removedIB. High-grade carcinoma with no myometrial invasionIB1: Negative nodesIB2: No nodes removedIC. Low-grade carcinoma with half or greater myometrial invasionIC1: Negative nodesIC2: No nodes removedID. High-grade carcinoma with any myometrial invasionID1: Negative nodesID2: No nodes removedResultsData from 1843 patients were analyzed. When patients were restaged with our proposed system, the 5-year overall survival significantly differed (P < 0.001): IA1, 96.7%; IA2, 92.2%; IB1, 92.2%; IB2, 76.4%; IC1, 83.9%; IC2, 78.6%; ID1, 81.1%; and ID2, 68.8%. The bootstrap-corrected concordance probability estimate for the proposed system was 0.627 (95% confidence interval, 0.590–0.664) and was superior to the concordance probability estimate of 0.530 (95% confidence interval, 0.516–0.544) for the 2009 FIGO system.ConclusionsBy incorporating histological subtype, grade, myometrial invasion, and whether lymph nodes were removed, our proposed system for stage I endometrial cancer has a superior predictive ability over the 2009 FIGO staging system and provides a novel binary grading system (low-grade including endometrioid grade 1–2 lesions; high-grade carcinoma consisting of endometrioid grade 3 carcinomas and nonendometrioid carcinomas).

scholarly journals Protein and cholesterol electrophoresis of plasma samples from captive cownose ray (Rhinoptera bonasus)

2015 ◽  
Vol 27 (6) ◽  
pp. 688-695 ◽  
Author(s):  
Carolyn Cray ◽  
Marilyn Rodriguez ◽  
Cara Field ◽  
Alexa McDermott ◽  
Lynda Leppert ◽  
...  
Keyword(s):  
Plasma Samples ◽  
Cownose Ray ◽  
Rhinoptera Bonasus

HPV DNA patterns and disease implications in the follow-up of patients treated for HPV16 high-grade carcinoma in situ

2006 ◽  
Vol 78 (4) ◽  
pp. 494-500 ◽  
Author(s):  
Monica Cricca ◽  
Simona Venturoli ◽  
Antonio Maria Morselli-Labate ◽  
Silvano Costa ◽  
Donatella Santini ◽  
...  
Keyword(s):  
Carcinoma In Situ ◽  
High Grade ◽  
Hpv Dna ◽  
High Grade Carcinoma

Polymorphous low-grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma

2002 ◽  
Vol 41 (3) ◽  
pp. 250-259 ◽  
Author(s):  
R H W Simpson ◽  
J S Reis-Filho ◽  
E M Pereira ◽  
A C Ribeiro ◽  
A Abdulkadir
Keyword(s):  
Salivary Glands ◽  
Low Grade ◽  
High Grade ◽  
High Grade Carcinoma

Applying the Paris System for Reporting Urine Cytology Increases the Rate of Atypical Urothelial Cells in Benign Cases: A Need for Patient Management Recommendations

2016 ◽  
Vol 61 (1) ◽  
pp. 71-76 ◽  
Author(s):  
Rosario Granados ◽  
Joanny A. Duarte ◽  
Teresa Corrales ◽  
Encarnación Camarmo ◽  
Paloma Bajo
Keyword(s):  
False Positive Rate ◽  
Urine Cytology ◽  
Urinary Cytology ◽  
Low Grade ◽  
High Grade ◽  
Abnormal Cytology ◽  
Positive Rate ◽  
High Grade Carcinoma ◽  
Management Recommendations ◽  
The Impact

The Paris System (TPS) for reporting urinary cytology attempts to unify the terminology in this field. Objectives: To analyze the impact of adopting TPS by measuring nomenclature agreement and cytohistological correlation. Materials and Methods: Voided urine liquid-based cytology samples corresponding to 149 biopsy-proven cases (76 high-grade carcinomas, 40 low-grade carcinomas, and 33 benign lesions), were reclassified by the same pathologist using TPS. Diagnostic agreement and sensitivity for both nomenclature systems was measured. Results: When using TPS, the rate of atypical samples increased 8 times (from 3 to 24.2%) in benign cases, 10 times (from 2.5 to 25%) in low-grade carcinomas, and 2.4 times (from 6.6 to 15.8%) in high-grade carcinomas. The false-positive rate (abnormal cytology in negative or low-grade carcinoma cases) increased from 11 to 34.2%. Sensitivity was higher (63 vs. 49%) with TPS at the expense of a lower specificity (73 vs. 91%). The agreement between both nomenclatures was moderate for negative and high-grade carcinoma cases (k = 0.42 and 0.56, respectively) and weak for low-grade tumors (k = 0.35). Conclusions: Adopting TPS for reporting urine cytology results in a considerable increase in atypical diagnoses, improving sensitivity but lowering specificity. Appropriate management recommendations for patients with an atypical cytological diagnosis are required.

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