DA-9701 improves colonic transit time and symptoms in patients with functional constipation: A prospective study

2017 ◽  
Vol 32 (12) ◽  
pp. 1943-1948 ◽  
Author(s):  
Su Young Kim ◽  
Hyun Sun Woo ◽  
Kyoung Oh Kim ◽  
Sung Han Choi ◽  
Kwang An Kwon ◽  
...  
Keyword(s):  
Prospective Study ◽  
Transit Time ◽  
Functional Constipation ◽  
Colonic Transit ◽  
Colonic Transit Time ◽  
A Prospective Study

Assessment of stool frequency and colonic transit time in Indian children with functional constipation and healthy controls

2018 ◽  
Vol 37 (5) ◽  
pp. 410-415 ◽  
Author(s):  
Upender Shava ◽  
Surender Kumar Yachha ◽  
Anshu Srivastava ◽  
Ujjal Poddar ◽  
Moinak Sen Sarma
Keyword(s):  
Transit Time ◽  
Functional Constipation ◽  
Colonic Transit ◽  
Stool Frequency ◽  
Colonic Transit Time ◽  
Healthy Controls ◽  
Indian Children

scholarly journals Normative Values for Colonic Transit Time and Patient Assessment of Constipation in Adults With Functional Constipation: Systematic Review With Meta-Analysis

2017 ◽  
Vol 10 ◽  
pp. 117955221772934 ◽  
Author(s):  
Larry E Miller ◽  
Alvin Ibarra ◽  
Arthur C Ouwehand
Keyword(s):  
Publication Bias ◽  
Transit Time ◽  
Meta Analysis ◽  
Functional Constipation ◽  
Colonic Transit ◽  
Colonic Transit Time ◽  
Significant Heterogeneity ◽  
Patient Assessment ◽  
Rome Iii ◽  
Meta Regression

Availability of normative patient outcome data may assist in designing experiments and estimating sample sizes. The purpose of this review was to determine normative ranges for colonic transit time (CTT), Patient Assessment of Constipation-Symptoms (PAC-SYM), and Patient Assessment of Constipation-Quality of Life (PAC-QOL) in adults diagnosed with functional constipation per Rome III guidelines. Pooled estimates were derived from random-effects meta-analysis. Meta-regression was used to explore sources of heterogeneity among studies. A total of 24 studies (3786 patients) were included in the review. In 10 studies with 1119 patients, pooled CTT was 58 hours (95% confidence interval [CI]: 50-65 hours). Publication bias was not evident (Egger P = .51); heterogeneity was high ( I2 = 92%, P < .001). In meta-regression, geographical location explained 57% of the between-study variance, with CTT significantly longer in studies conducted in Europe (71 hours) compared with Asia (49 hours) or the Americas (44 hours). In 9 studies with 2061 patients, pooled PAC-SYM was 1.70 (95% CI: 1.58-1.83). Publication bias was not evident (Egger P = .44). Heterogeneity was high ( I2 = 90%, P < .001); however, no study or patient factor influenced PAC-SYM in meta-regression. In 12 studies with 1805 patients, pooled PAC-QOL was 1.97 (95% CI: 1.70-2.24). Publication bias was not evident (Egger P = .28); heterogeneity was high ( I2 = 98%, P < .001). In meta-regression, age explained 52% of the between-study variance, with older age associated with lower PAC-QOL scores. Overall, in adults diagnosed with functional constipation per Rome III criteria, significant heterogeneity in CTT, PAC-SYM, and PAC-QOL exists among studies. Variability among studies may be explained by geography and patient factors.

Sign in / Sign up

Export Citation Format

Share Document