Randomized trial of oral sulfate solution versus polyethylene glycol–ascorbic acid for bowel cleansing in elderly people

2021 ◽  
Author(s):  
Seung‐Joo Nam ◽  
Sung Chul Park ◽  
Sung Joon Lee ◽  
Sang Hoon Lee ◽  
Ji Hyun Kim ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Polyethylene Glycol ◽  
Randomized Trial ◽  
Elderly People ◽  
Sulfate Solution ◽  
Solution Versus ◽  
Bowel Cleansing

scholarly journals Oral Sulfate Solution versus Polyethylene Glycol as a Single-Day Preparation for Colonoscopy: A Randomized Control Trial

2019 ◽  
Vol 10 (03) ◽  
pp. 174-177
Author(s):  
Bhavik Bharat Shah ◽  
Bubun Patel ◽  
Mahesh Kumar Goenka
Keyword(s):  
Polyethylene Glycol ◽  
Bowel Preparation ◽  
Statistical Significance ◽  
Sulfate Solution ◽  
Cecal Intubation ◽  
Solution Versus ◽  
Bowel Cleansing ◽  
Cecal Intubation Time ◽  
Colonoscopy Preparation ◽  
To Receive

Abstract Background Colonoscopy is a principal diagnostic tool for most colonic disorders. Adequate bowel preparation is essential for proper visualization of the mucosa. The aim of this study was to compare the tolerability, efficacy, and safety profile of 1 L of oral sulfate solution (OSS) in comparison to 2 L of polyethylene glycol (PEG) solution. Methods In this single-center prospective study conducted at our institute, patients were randomly assigned to receive either OSS or PEG solutions for colonoscopy preparation. Patients enrolled in either group completed a questionnaire assessing the taste of the solution used, adverse effects, and number of stools passed. Grading of the bowel cleansing quality was done as per Boston Bowel Preparation (BBP) score. Results Total of 400 patients, with 222 patients in the PEG group and 178 patients in the OSS group, were assessed. In the PEG group, 148 (66.75%) patients were males and in the OSS group 112 (62.9%) patients were males. There was no statistical significance on comparison of the taste as “good” or “bad” in both groups. All the adverse events were mild to moderate in intensity and their frequencies were comparable for both the groups. The OSS group had better bowel preparation as per the BBP score (p = 0.021) and lesser cecal intubation time (p = 0.028). Conclusion The present study demonstrated that 1 L of OSS is better than the well-established 2 L PEG solution, in terms of bowel preparation and shorter time to cecal intubation.

Randomized trial of 2-L polyethylene glycol + ascorbic acid versus 4-L polyethylene glycol as bowel cleansing for colonoscopy in an optimal setting

2014 ◽  
Vol 29 (6) ◽  
pp. 1223-1228 ◽  
Author(s):  
Chang Mo Moon ◽  
Dong Il Park ◽  
Young Ghil Choe ◽  
Dong-Hoon Yang ◽  
Yeon Hwa Yu ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Polyethylene Glycol ◽  
Randomized Trial ◽  
Acid Versus ◽  
Bowel Cleansing ◽  
Optimal Setting

scholarly journals Optimal intake of clear liquids during preparation for afternoon colonoscopy with low-volume polyethylene glycol plus ascorbic acid

2017 ◽  
Vol 05 (06) ◽  
pp. E416-E423 ◽  
Author(s):  
Masahiro Tajika ◽  
Tsutomu Tanaka ◽  
Makoto Ishihara ◽  
Yutaka Hirayama ◽  
Sachiyo Oonishi ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Polyethylene Glycol ◽  
Good News ◽  
Controlled Study ◽  
Standard Regimen ◽  
Endoscopic Findings ◽  
Bowel Cleansing ◽  
The Difference ◽  
Colonoscopy Preparation ◽  
Lavage Solution

Abstract Background and study aims The standard colonoscopy preparation regimen in Japan for afternoon procedures is sequential intake of 1 L of polyethylene glycol electrolyte lavage solution containing ascorbic acid (PEG-ASC), 0.5 L of clear liquid, 0.5 L of PEG-ASC, and finally 0.25 L of clear fluids (all at a rate of 0.25 L every 15 min). However, this regimen seems poorly tolerated and complicated for many patients compared to previous regimen of polyethylene glycol electrolyte lavage solution. The aim of this study was to evaluate an alternate regimen of 0.5 L of PEG-ASC followed by 0.25 L clear liquids, repeated 3 times. Patients and methods This was a single-blinded, non-inferiority, randomized controlled study. Subjects were randomized to the standard regimen or the alternate regimen using a web-based registry system. All patients were instructed to eat a pre-packaged, low residue diet and to take sodium picosulfate hydrate the day before colonoscopy. The Boston Bowel Preparation Scale was used to evaluate bowel cleansing, and a 3-point scale was used to assess mucosal visibility. The primary endpoint was successful bowel cleansing. The acceptability, tolerability, safety, and endoscopic findings of these two regimens were secondary endpoints. Results A total of 409 patients were randomized to either the standard regimen (n = 204, males 54.0 %, mean age 65.5 years) or the alternate regimen (n = 205, 54.6 %, 65.0 years). The rates of successful bowel cleansing were 71.1 % (64.3 – 77.2 %) with the standard regimen vs. 75.1 % (68.6 – 80.9 %) with the alternate regimen (95 % lower confidence limit, for the difference = – 4.6, non-inferiority P < 0.05). No significant differences were found in tolerability, safety, and endoscopic findings. Conclusion The alternate regimen and standard regimen are clinically equivalent with respect to cleansing efficacy and acceptability, tolerability, safety, and endoscopic findings. These results are good news for patients with difficulty drinking the first liter of PEG-ASC.

Randomized Trial of Low-Volume PEG Solution Versus Standard PEG + Electrolytes for Bowel Cleansing Before Colonoscopy

2008 ◽  
Vol 103 (4) ◽  
pp. 883-893 ◽  
Author(s):  
Christian Ell ◽  
Wolfgang Fischbach ◽  
Hans-Joachim Bronisch ◽  
Stefan Dertinger ◽  
Peter Layer ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Solution Versus ◽  
Bowel Cleansing ◽  
Low Volume

scholarly journals Oral Sulfate Solution is as Effective as 2 L Polyethylene Glycol Plus Ascorbic Acid

2020 ◽  
Vol 53 (5) ◽  
pp. 503-504
Author(s):  
Sung Hyun Shin ◽  
Kwang An Kwon
Keyword(s):  
Ascorbic Acid ◽  
Polyethylene Glycol ◽  
Sulfate Solution

Comparison Between an Oral Sulfate Solution and a 2 L of Polyethylene Glycol/Ascorbic Acid as a Split Dose Bowel Preparation for Colonoscopy

2019 ◽  
Vol 53 (10) ◽  
pp. e431-e437 ◽  
Author(s):  
Han Hee Lee ◽  
Chul-Hyun Lim ◽  
Jin Su Kim ◽  
Yu Kyung Cho ◽  
Bo-In Lee ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Polyethylene Glycol ◽  
Bowel Preparation ◽  
Sulfate Solution ◽  
Split Dose
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