Determination of hepatic clearance by derivations of the indocyanine green retention test in cirrhosis

2022 ◽  
Author(s):  
Søren Møller ◽  
Jens H. Henriksen ◽  
Sannia Sjöstedt ◽  
Flemming Bendtsen
Keyword(s):  
Indocyanine Green ◽  
Retention Test ◽  
Hepatic Clearance

Clearance and Non-Invasive Determination of the Hepatic Extraction of Indocyanine Green in Baboons and Man

1983 ◽  
Vol 64 (2) ◽  
pp. 207-212 ◽  
Author(s):  
S. L. Grainger ◽  
P. W. N. Keeling ◽  
I. M. H. Brown ◽  
J. H. Marigold ◽  
R. P. H. Thompson
Keyword(s):  
Indocyanine Green ◽  
Accurate Determination ◽  
Liver Blood Flow ◽  
Compartment Model ◽  
Hepatic Extraction ◽  
Non Invasive ◽  
Two Compartment Model ◽  
Hepatic Extraction Ratio ◽  
Plasma Disappearance Curve

1. The disposition of an intravenous bolus of indocyanine green (ICG) has been studied in healthy man and baboons using a novel analysis of a two compartment pharmacokinetic model. 2. This analysis enabled the hepatic extraction ratio (ER) of dye to be determined solely from the plasma disappearance curve, and the ER determined did not differ from that measured by hepatic vein catheterization. 3. When compared with clearance measured at steady state, the two compartment model gave a significantly more accurate determination of plasma clearance than did the conventional one compartment model. 4. It is concluded that, in health, liver blood flow may be calculated accurately and noninvasively after a single intravenous injection of ICG.

scholarly journals The indocyanine green retention test as a non-invasive marker for esophageal varices in patients with hepatocellular carcinoma

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hsiao-Sheng Lu ◽  
I-Fang Hsin ◽  
Ping-Hsien Chen ◽  
Tsung-Chieh Yang ◽  
Chung-Yu Chang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Indocyanine Green ◽  
Esophageal Varices ◽  
Retention Test ◽  
Non Invasive

The Impact of a Heterozygous SLCO1B3 Null Variant on the Indocyanine Green Retention Test

2020 ◽  
Vol 109 (10) ◽  
pp. 3206-3209
Author(s):  
Kazuya Anzai ◽  
Kota Tsuruya ◽  
Masashi Morimachi ◽  
Yoshitaka Arase ◽  
Shunji Hirose ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Retention Test ◽  
The Impact

Nicardipine increases hepatic blood flow and the hepatic clearance of indocyanine green in patients with cirrhosis

1994 ◽  
Vol 20 (6) ◽  
pp. 792-796 ◽  
Author(s):  
Juan Carlos García-Pagán ◽  
Fausto Feu ◽  
Angelo Luca ◽  
Mercedes Fernández ◽  
Pilar Pizcueta ◽  
...  
Keyword(s):  
Blood Flow ◽  
Indocyanine Green ◽  
Hepatic Blood Flow ◽  
Hepatic Clearance

scholarly journals Use of an optical density ruler in measurements of dye-dilution curves

1964 ◽  
Vol 19 (2) ◽  
pp. 347-353 ◽  
Author(s):  
James B. Bassingthwaighte ◽  
Anthony W. T. Edwards ◽  
Earl H. Wood
Keyword(s):  
Indocyanine Green ◽  
Optical Density ◽  
Light Transmission ◽  
Accurate Estimation ◽  
Calibration Constant ◽  
Nonhomogeneous Media ◽  
Dye Dilution ◽  
Logarithmic Relationship ◽  
Dilution Curves

The inapplicability of Beer's law to densitometry of dyes in whole blood or other nonhomogeneous media has been long known. When using a densitometer whose output is directly proportional to the light transmitted, a simple transformation— log X = log (x – x0)—can be employed to allow rapid, accurate estimation of dye concentration. This is facilitated by use of an optical density ruler. The transformation, X = x – x0, can be made mechanically, by shifting the infinity position of the ruler with reference to the zero light transmission position, or electrically, by appropriate use of zero suppression in the densitometer circuit. The transformation results in an exponential (logarithmic) relationship between light transmitted and concentration of the dye (indocyanine green). Readings of relative optical density obtained by use of the ruler are multiplied by a calibration constant to calculate dye concentration. The principles of the transformation have been applied to the determination of the optimal zero suppression required for maintenance of constant sensitivity of the densitometer in the presence of various levels of background dye. densitometer calibration; indocyanine green densitometer; calibration of dye-dilution curves; correction of dye-dilution curves Submitted on September 13, 1963

Nontraditional effects of protein binding and hematocrit on uptake of indocyanine green by perfused rat liver

1997 ◽  
Vol 273 (1) ◽  
pp. G227-G238 ◽  
Author(s):  
P. Ott ◽  
R. A. Weisiger
Keyword(s):  
Indocyanine Green ◽  
Protein Binding ◽  
Plasma Volume ◽  
Protein Concentration ◽  
Hepatic Clearance ◽  
Hepatic Uptake ◽  
Perfused Rat Liver ◽  
Total Plasma ◽  
Plasma Protein Concentration ◽  
Total Plasma Protein

We used a novel parameter-free approach to study the role of protein binding in the hepatic clearance of indocyanine green (ICG) from reconstituted pig blood by perfused rat liver. Either perfusate total plasma protein concentration or hematocrit was changed. By analyzing protein concentration ratios or plasma volume ratios relative to ratios of intrinsic hepatic clearance of ICG (K), it was possible to evaluate current models of hepatic uptake of protein-bound ligands without precise knowledge of some of the model parameters. A four-fold increase in the total plasma protein concentration produced only a 36% decrease in K. This was substantially less than predicted by the traditional model, where K is proportional to the free concentration of ligand. Because an unstirred water layer effect could not by itself account for the observations, the effects of binding disequilibrium in the sinusoids or uptake directly from the bound pool had to be considered. To discriminate, hematocrit was increased from 15% to 29%, causing a 20% decrease in the sinusoidal plasma volume. A significant reduction in K strongly suggested a sinusoidal binding disequilibrium effect. The dissociation rate constant predicted by this model was confirmed by in vitro measurement, further supporting this interpretation. The simple experimental design and its parameter-free evaluation provide a new tool for investigating the hepatic uptake of protein-bound ligands.

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