scholarly journals Early Functional Limitations in Cognitively Normal Older Adults Predict Diagnostic Conversion to Mild Cognitive Impairment

2017 ◽  
Vol 65 (6) ◽  
pp. 1152-1158 ◽  
Author(s):  
Sarah Tomaszewski Farias ◽  
Karen Lau ◽  
Danielle Harvey ◽  
Katherine G. Denny ◽  
Cheyanne Barba ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Limitations ◽  
Cognitively Normal

scholarly journals Financial Capacity and Regional Cerebral Tau in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer’s Disease Dementia

2020 ◽  
pp. 1-10
Author(s):  
Christopher Gonzalez ◽  
Nicole S. Tommasi ◽  
Danielle Briggs ◽  
Michael J. Properzi ◽  
Rebecca E. Amariglio ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Stage ◽  
Cognitively Normal ◽  
Financial Capacity ◽  
Posterior Cingulate ◽  
Dorsolateral Prefrontal

Background: Financial capacity is often one of the first instrumental activities of daily living to be affected in cognitively normal (CN) older adults who later progress to amnestic mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia. Objective: The objective of this study was to investigate the association between financial capacity and regional cerebral tau. Methods: Cross-sectional financial capacity was assessed using the Financial Capacity Instrument –Short Form (FCI-SF) in 410 CN, 199 MCI, and 61 AD dementia participants who underwent flortaucipir tau positron emission tomography from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Linear regression models with backward elimination were used with FCI-SF total score as the dependent variable and regional tau and tau-amyloid interaction as predictors of interest in separate analyses. Education, age sex, Rey Auditory Verbal Learning Test Total Learning, and Trail Making Test B were used as covariates. Results: Significant associations were found between FCI-SF and tau regions (entorhinal: p <  0.001; inferior temporal: p <  0.001; dorsolateral prefrontal: p = 0.01; posterior cingulate: p = 0.03; precuneus: p <  0.001; and supramarginal gyrus: p = 0.005) across all participants. For the tau-amyloid interaction, significant associations were found in four regions (amyloid and dorsolateral prefrontal tau interaction: p = 0.005; amyloid and posterior cingulate tau interaction: p = 0.005; amyloid and precuneus tau interaction: p <  0.001; and amyloid and supramarginal tau interaction: p = 0.002). Conclusion: Greater regional tau burden was modestly associated with financial capacity impairment in early-stage AD. Extending this work with longitudinal analyses will further illustrate the utility of such assessments in detecting clinically meaningful decline, which may aid clinical trials of early-stage AD.

scholarly journals P1-309: NEUROPSYCHIATRIC SYMPTOMS PREDICT CONVERSION TO MILD COGNITIVE IMPAIRMENT IN COGNITIVELY NORMAL OLDER ADULTS

2019 ◽  
Vol 15 ◽  
pp. P361-P362
Author(s):  
Shanna Cooper ◽  
Kelsey R. Thomas ◽  
Alexandra J. Weigand ◽  
Christina G. Wong ◽  
Emily C. Edmonds ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Neuropsychiatric Symptoms ◽  
Cognitively Normal

IC-06-01: QUANTITATIVE SODIUM MRI IS MORE SENSITIVE THAN VOLUMETRY FOR DIFFERENTIATING BETWEEN OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT AND THOSE WHO ARE COGNITIVELY NORMAL

2006 ◽  
Vol 14 (7S_Part_1) ◽  
pp. P10-P11
Author(s):  
Vijay K. Venkatraman ◽  
Elaine Liu ◽  
Tie-Qiang Li ◽  
Brad Sutton ◽  
Christopher Steward ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitively Normal ◽  
Sodium Mri

scholarly journals Social Participation and the Risk for Developing Mild Cognitive Impairment and Dementia Among Older Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 13-13
Author(s):  
Hrafnhildur Eymundsdottir ◽  
Sigurveig Sigurdardottir ◽  
Alfons Ramel ◽  
Palmi Jonsson ◽  
Vilmundur Gudnason ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Social Participation ◽  
Community Dwelling ◽  
Cognitively Normal ◽  
Frequency Of Contact ◽  
Gene Environment ◽  
Vitamin D Levels

Abstract Introduction We aim to investigate the longitudinal associations between social participation and the risk of developing mild cognitive impairment (MCI|) and dementia over 5 years of follow-up among cognitively normal older adults. Methods A total of 2802 participants had complete follow-up data from Age-Gene/Environment-Susceptibility-Reykjavik-Study. Social participation was assessed by a questionnaire asking the frequency of contact with children, relatives, friends and neighbors. MCI and dementia were diagnosed according to international guidelines and by a team composed of a geriatrician, neurologist, neuropsychologist, and neuroradiologist. Logistic regression analysis was used to assess the associations. Results At baseline 8% (n=225) reported no social participation. Among cognitively normal participants at baseline, 5.6% (n=243) developed mild cognitive impairment and 2.4% (n= 103) developed dementia during a mean follow-up time of 5.2 years. After full adjustment with covariates including age, gender, education, marital status, vitamin D levels, depression and APOE ε4, those with no social participation at baseline were significantly more likely to develop MCI at follow-up (OR=1.953, P=0.001). However, social participation at baseline was not associated with higher dementia diagnosis at follow-up (OR= 1.490, P=0.194). Conclusions Community-dwelling old adults who are socially inactive are more likely to develop MCI than those who are socially active. Social participation might independently indicate impending changes in cognitive function among older adults.

Capacity to make decisions on medication management in Chinese older persons with mild cognitive impairment and mild Alzheimer's disease

2012 ◽  
Vol 24 (7) ◽  
pp. 1103-1111 ◽  
Author(s):  
Victor Wing-Cheong Lui ◽  
Linda Chiu-Wa Lam ◽  
Rachel Ching-Man Chau ◽  
Ada Wai-Tung Fung ◽  
Billy Mou-Lam Wong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Decision Making ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Older Persons ◽  
Medication Management ◽  
Community Dwelling ◽  
Decisional Capacity ◽  
Cognitively Normal

ABSTRACTBackground: This study aimed to assess if decisional capacity and the four decision-making abilities related to decisions concerning medication management were impaired among community-dwelling Chinese older persons in Hong Kong with amnestic mild cognitive impairment (MCI) and mild Alzheimer's disease (AD), as compared with cognitively normal older adults.Methods: Two hundred and ninety-one Chinese community-dwelling older adults were recruited. The four decision-making abilities and decisional capacity were assessed by using the Chinese version of the Assessment of Capacity for Everyday Decision-Making (ACED) and independent clinician ratings based on the definition in the UK Mental Capacity Act 2005, respectively.Results: Ninety-nine participants (34%) were diagnosed with MCI and ninety-five (33%) with mild AD. Although almost all (96%) of the participants in the MCI group were found to be mentally competent to make decisions on medication management in clinician ratings, their decision-making abilities as measured by the ACED were significantly lower than those of the cognitively normal controls.Conclusions: Results from this study suggest that abilities related to decisions on medication management are impaired before the clinical diagnosis of dementia is made. Use of specific and structured assessment of the relevant decisional abilities may enhance clinical judgment.

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