Correlation of clinicopathological characteristics and direct immunofluorescence studies in oral lichenoid lesion in Thai patients

Pemphigoid gestationis (PG) is a rare vesiculobullous dermatosis of pregnancy. It is commonly seen in second or third trimester. The diagnosis is frequently made with direct immunofluorescence studies of perilesional skin. Prompt recognition and appropriate management may reduce morbidity of this disease. Herein we present a case of pemphigoid gestationis occurring in a 33-year-old primigravida woman with symptoms of generalized pruritus.

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Canine Pemphigus Foliaceus with Concurrent Immune-Mediated Thrombocytopenia

Journal of the American Animal Hospital Association ◽

10.5326/jaaha-ms-6044 ◽

2015 ◽

Vol 51 (1) ◽

pp. 56-63 ◽

Cited By ~ 1

Author(s):

Shinpei Kawarai ◽

Masaharu Hisasue ◽

Shinobu Matsuura ◽

Tetsuro Ito ◽

Yukari Inoue ◽

...

Keyword(s):

Primary Care ◽

Flow Cytometry ◽

Definitive Diagnosis ◽

Direct Immunofluorescence ◽

Pemphigus Foliaceus ◽

Detailed Report ◽

Platelet Surface ◽

Immune Mediated ◽

Stratum Spinosum ◽

Immunofluorescence Studies

A 3 yr old wirehaired fox terrier was presented to his primary care veterinarian with fever, thrombocytopenia, and generalized crusting dermatitis. The skin lesion had progressed for at least 18 days, and thrombocytopenia had developed 3 days before presentation. Histopathology and direct immunofluorescence studies of the skin were consistent with pemphigus foliaceus (PF). Immunofluorescence revealed immunoglobulin G deposition around the keratinocytes in the stratum spinosum. A diagnosis of immune-mediated thrombocytopenia (IMT) was confirmed by the presence of platelet surface-associated immunoglobulin using flow cytometry. Systemic immunosuppressive therapy with cyclosporine and azathioprine was effective, and the dog survived for >2 years from the initial presentation. IMT is rarely associated with PF. This appears to be the first detailed report of a definitive diagnosis of concurrent PF and IMT in a dog. The authors' findings indicate that canine PF could be complicated by hematologic immune-mediated diseases such as IMT.

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Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease

Case Reports in Medicine ◽

10.1155/2018/5980937 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Thanisorn Sukakul ◽

Supenya Varothai

Keyword(s):

Autoimmune Disease ◽

Rare Variant ◽

Clinical Presentation ◽

Final Diagnosis ◽

Direct Immunofluorescence ◽

Unusual Manifestation ◽

Blood Tests ◽

Immunofluorescence Studies ◽

Elisa Technique ◽

Pemphigus Vegetans

Pemphigus vegetans is a rare variant of deep acantholytic pemphigus which usually presents with vesiculobullous rash and vegetative plaques on the folds. We report a case of pemphigus vegetans patient who presented with rashes on tips of fingers and toes resembling paronychia and onychomadesis that misled the diagnosis for months. The final diagnosis of Hallopeau-type pemphigus vegetans was made based on histopathology and direct immunofluorescence studies. Interestingly, not only the clinical presentation was atypical, but blood tests for anti-desmoglein 1 and 3 antibodies by ELISA technique were also negative. Thus, the rare unusual manifestation of pemphigus vegetans in this patient may associate with different autoantibodies to desmosomal proteins compared with those of classic pemphigus patients.

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