scholarly journals Disrupted circadian expression of beta‐arrestin 2 affects reward‐related µ‐opioid receptor function in alcohol dependence

2021 ◽  
Author(s):  
Marcus W Meinhardt ◽  
Francesco Giannone ◽  
Nathalie Hirth ◽  
Dusan Bartsch ◽  
Santi M Spampinato ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Opioid Receptor ◽  
Receptor Function ◽  
Circadian Expression

scholarly journals Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence

2021 ◽  
pp. 026988112199199 ◽  
Author(s):  
Miriam Sebold ◽  
Maria Garbusow ◽  
Deniz Cerci ◽  
Ke Chen ◽  
Christian Sommer ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Opioid Receptor ◽  
Mechanistic Model ◽  
Critical Role ◽  
Opioid System ◽  
Operant Behaviour ◽  
Oprm1 Gene ◽  
Potential Biomarker ◽  
A118g Polymorphism

Background: Pavlovian-to-instrumental transfer (PIT) quantifies the extent to which a stimulus that has been associated with reward or punishment alters operant behaviour. In alcohol dependence (AD), the PIT effect serves as a paradigmatic model of cue-induced relapse. Preclinical studies have suggested a critical role of the opioid system in modulating Pavlovian–instrumental interactions. The A118G polymorphism of the OPRM1 gene affects opioid receptor availability and function. Furthermore, this polymorphism interacts with cue-induced approach behaviour and is a potential biomarker for pharmacological treatment response in AD. In this study, we tested whether the OPRM1 polymorphism is associated with the PIT effect and relapse in AD. Methods: Using a PIT task, we examined three independent samples: young healthy subjects ( N = 161), detoxified alcohol-dependent patients ( N = 186) and age-matched healthy controls ( N = 105). We used data from a larger study designed to assess the role of learning mechanisms in the development and maintenance of AD. Subjects were genotyped for the A118G (rs1799971) polymorphism of the OPRM1 gene. Relapse was assessed after three months. Results: In all three samples, participants with the minor OPRM1 G-Allele (G+ carriers) showed increased expression of the PIT effect in the absence of learning differences. Relapse was not associated with the OPRM1 polymorphism. Instead, G+ carriers displaying increased PIT effects were particularly prone to relapse. Conclusion: These results support a role for the opioid system in incentive salience motivation. Furthermore, they inform a mechanistic model of aberrant salience processing and are in line with the pharmacological potential of opioid receptor targets in the treatment of AD.

Brain regional μ-opioid receptor function in rat lines selected for differences in alcohol preference

2002 ◽  
Vol 448 (2-3) ◽  
pp. 157-163 ◽  
Author(s):  
Sanna L Soini ◽  
Petri Hyytiä ◽  
Esa R Korpi
Keyword(s):  
Opioid Receptor ◽  
Alcohol Preference ◽  
Receptor Function ◽  
Μ Opioid Receptor

Fluorescent opioid receptor ligands as tools to study opioid receptor function

2021 ◽  
pp. 107132
Author(s):  
Despina Giakomidi ◽  
Mark F. Bird ◽  
Remo Guerrini ◽  
Girolamo Calo ◽  
David G. Lambert
Keyword(s):  
Opioid Receptor ◽  
Receptor Function ◽  
Receptor Ligands ◽  
Opioid Receptor Ligands

scholarly journals Alcohol dependence and opioid receptor —Pharmacological profile of nalmefene—

2020 ◽  
Vol 155 (3) ◽  
pp. 145-148
Author(s):  
Yuta Ohgi
Keyword(s):  
Alcohol Dependence ◽  
Opioid Receptor ◽  
Pharmacological Profile

Glycosylated phosducin-like protein long regulates opioid receptor function in mouse brain

2002 ◽  
Vol 42 (6) ◽  
pp. 813-828 ◽  
Author(s):  
J. Garzón ◽  
M. Rodríguez-Díaz ◽  
A. López-Fando ◽  
A. García-España ◽  
P. Sánchez-Blázquez
Keyword(s):  
Opioid Receptor ◽  
Mouse Brain ◽  
Receptor Function

scholarly journals Untangling the complexity of opioid receptor function

2018 ◽  
Vol 43 (13) ◽  
pp. 2514-2520 ◽  
Author(s):  
Rita J. Valentino ◽  
Nora D. Volkow
Keyword(s):  
Opioid Receptor ◽  
Receptor Function

scholarly journals An Evaluation of μ-Opioid Receptor (OPRM1) as a Predictor of Naltrexone Response in the Treatment of Alcohol Dependence

2008 ◽  
Vol 65 (2) ◽  
pp. 135 ◽  
Author(s):  
Raymond F. Anton ◽  
Gabor Oroszi ◽  
Stephanie O’Malley ◽  
David Couper ◽  
Robert Swift ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Opioid Receptor ◽  
Μ Opioid Receptor

Opioid Receptors: Cellular and Molecular Mechanisms Underlying Opioid Receptor Function

2012 ◽  
pp. 1304-1312
Author(s):  
Lisa Stowers ◽  
Sandeepa Dey ◽  
Vladana Vukojević ◽  
Yu Ming ◽  
Lars Terenius
Keyword(s):  
Opioid Receptor ◽  
Opioid Receptors ◽  
Molecular Mechanisms ◽  
Receptor Function

Direct evidence for the up-regulation of spinal u-opioid receptor function after repeated stimulation of kappa-opioid receptors in the mouse

2003 ◽  
Vol 18 (9) ◽  
pp. 2498-2504 ◽  
Author(s):  
Minoru Narita ◽  
Junaidi Khotib ◽  
Hirokazu Mizoguchi ◽  
Masami Suzuki ◽  
Satoru Ozaki ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Opioid Receptors ◽  
Direct Evidence ◽  
Receptor Function ◽  
Kappa Opioid Receptors ◽  
Kappa Opioid ◽  
Repeated Stimulation ◽  
Stimulation Of

scholarly journals Multiple Actions of Spinophilin Regulate Mu Opioid Receptor Function

Neuron ◽  
2008 ◽  
Vol 58 (2) ◽  
pp. 238-247 ◽  
Author(s):  
Joanna J. Charlton ◽  
Patrick B. Allen ◽  
Kassi Psifogeorgou ◽  
Sumana Chakravarty ◽  
Ivone Gomes ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Mu Opioid Receptor ◽  
Receptor Function ◽  
Mu Opioid
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