The different mechanisms of peripheral and central TLR4 on chronic postsurgical pain in rats

2021 ◽  
Author(s):  
Xuemin Han ◽  
Jinping Shao ◽  
Xiuhua Ren ◽  
Yaru Li ◽  
Wenli Yu ◽  
...  
Keyword(s):  
Postsurgical Pain ◽  
Chronic Postsurgical Pain

scholarly journals A prospective cohort register-based study of chronic postsurgical pain and long-term use of pain medication after otorhinolaryngological surgery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nina Graf ◽  
Katharina Geißler ◽  
Winfried Meißner ◽  
Orlando Guntinas-Lichius
Keyword(s):  
Rating Scale ◽  
Numeric Rating Scale ◽  
Postsurgical Pain ◽  
Average Pain Intensity ◽  
Chronic Postsurgical Pain ◽  
Average Pain ◽  
Patients At Risk ◽  
Perioperative Assessment ◽  
Numeric Rating

AbstractData on chronic postsurgical pain (CPSP) after otorhinolaryngological surgery are sparse. Adult in-patients treated in 2017 were included into the prospective PAIN OUT registry. Patients’ pain on the first postoperative day (D1), after six months (M6) and 12 months (M12) were evaluated. Determining factor for CPSP was an average pain intensity ≥ 3 (numeric rating scale 0–10) at M6. Risk factors associated with CPSP were evaluated by univariate and multivariate analyses. 10% of 191 included patients (60% male, median age: 52 years; maximal pain at D1: 3.5 ± 2.7), had CPSP. Average pain at M6 was 0.1 ± 0.5 for patients without CPSP and 4.2 ± 1.2 with CPSP. Average pain with CPSP still was 3.7 ± 1.1 at M12. Higher ASA status (Odds ratio [OR] = 4.052; 95% confidence interval [CI] = 1.453–11.189; p = 0.007), and higher minimal pain at D1 (OR = 1.721; CI = 1.189–2.492; p = 0.004) were independent predictors of CPSP at M6. Minimal pain at D1 (OR = 1.443; CI = 1.008–2.064; p = 0.045) and maximal pain at M6 (OR = 1.665; CI = 1.340–2.069; p < 0.001) were independent predictors for CPSP at M12. CPSP is an important issue after otorhinolaryngological surgery. Better instrument for perioperative assessment should be defined to identify patients at risk for CPSP.

The Associations Between Severity of Early Postoperative Pain, Chronic Postsurgical Pain and Plasma Concentration of Stable Nitric Oxide Products After Breast Surgery

2006 ◽  
Vol 103 (4) ◽  
pp. 995-1000 ◽  
Author(s):  
Gabriella Iohom ◽  
Hamza Abdalla ◽  
James O??Brien ◽  
Szilvia Szarvas ◽  
Vivienne Larney ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Plasma Concentration ◽  
Postoperative Pain ◽  
Breast Surgery ◽  
Postsurgical Pain ◽  
Chronic Postsurgical Pain

Acute and chronic postsurgical pain after living liver donation: Incidence and predictors

2015 ◽  
Vol 21 (8) ◽  
pp. 1109-1109 ◽  
Author(s):  
Akihiko Soyama ◽  
Mitsuhisa Takatsuki ◽  
Masaaki Hidaka ◽  
Hajime Imamura ◽  
Tamotsu Kuroki ◽  
...  
Keyword(s):  
Postsurgical Pain ◽  
Chronic Postsurgical Pain ◽  
Liver Donation ◽  
Living Liver Donation
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