scholarly journals The HDL mimetic CER‐001 remodels plasma lipoproteins and reduces kidney lipid deposits in inherited lecithin:cholesterol acyltransferase deficiency

2021 ◽  
Author(s):  
Chiara Pavanello ◽  
Marta Turri ◽  
Arianna Strazzella ◽  
Patrizia Tulissi ◽  
Stefano Pizzolitto ◽  
...  
Keyword(s):  
Plasma Lipoproteins ◽  
Lecithin:Cholesterol Acyltransferase

Plasma Lipoproteins in Familial Lecithin:Cholesterol Acyltransferase Deficiency: Effects of Dietary Manipulation

1975 ◽  
Vol 35 ◽  
pp. 3-30 ◽  
Author(s):  
John Glomset ◽  
Kaare Norum ◽  
Alex Nichols ◽  
Weiling King ◽  
Carolyn Mitchell ◽  
...  
Keyword(s):  
Plasma Lipoproteins ◽  
Dietary Manipulation ◽  
Lecithin:Cholesterol Acyltransferase

Plasma Lipoproteins in Familial Lecithin:Cholesterol Acyltransferase Deficiency: Effects of Incubation with Lecithin: Cholesterol Acyltransferase in vitro

1975 ◽  
Vol 35 (sup142) ◽  
pp. 31-55 ◽  
Author(s):  
Kaare R. Norum ◽  
John A. Glomset ◽  
Alex V. Nichols ◽  
Trudy Forte ◽  
John J. Albers ◽  
...  
Keyword(s):  
Cholesterol Acyltransferase ◽  
Plasma Lipoproteins ◽  
Lecithin:Cholesterol Acyltransferase ◽  
Lecithin Cholesterol Acyltransferase

scholarly journals Plasma lipoproteins in familial lecithin:cholesterol acyltransferase deficiency: lipid composition and reactivity in vitro

1970 ◽  
Vol 49 (10) ◽  
pp. 1827-1837 ◽  
Author(s):  
John A. Glomset ◽  
Kaare R. Norum ◽  
Weiling King
Keyword(s):  
Lipid Composition ◽  
Plasma Lipoproteins ◽  
Lecithin:Cholesterol Acyltransferase

scholarly journals Plasma activities of lecithin:cholesterol acyltransferase, lipid transfer proteins and post-heparin lipases in inbred strains of rabbits hypo- or hyper-responsive to dietary cholesterol

1993 ◽  
Vol 293 (3) ◽  
pp. 729-734 ◽  
Author(s):  
G W Meijer ◽  
P N M Demacker ◽  
A Van Tol ◽  
J E M Groener ◽  
J G P Van der Palen ◽  
...  
Keyword(s):  
Plasma Cholesterol ◽  
Strain Difference ◽  
Dietary Cholesterol ◽  
Inbred Strains ◽  
Plasma Lipoproteins ◽  
High Cholesterol Diet ◽  
Lecithin:Cholesterol Acyltransferase ◽  
Triacylglycerol Lipase ◽  
Transfer Protein ◽  
Pltp Activity

Plasma lipoproteins, plasma activities of lecithin:cholesterol acyltransferase (LCAT), phospholipid transfer protein (PLTP), cholesteryl ester transfer protein (CETP) and post-heparin lipases were measured before and after cholesterol challenge in two inbred strains of rabbits with either a high (hyper-responders) or a low (hyporesponders) response of plasma cholesterol to dietary cholesterol. The purpose of this study was to provide clues about the mechanisms underlying the effect of dietary cholesterol on lipoprotein levels and composition, and particularly those underlying the strain difference of this effect. Cholesterol feeding (0.15 g of cholesterol/100 g of diet) caused increased plasma total cholesterol concentrations and an increased ratio of cholesteryl esters:triacylglycerol in all lipoprotein particles in both strains; these effects were significantly greater in hyper- than hypo-responsive rabbits. Feeding on the high-cholesterol diet lowered plasma triacylglycerols in hyper-responders, but caused increased plasma triacylglycerol levels in hyporesponders. This was accompanied by significantly greater increases in the activities of hepatic triacylglycerol lipase and lipoprotein lipase in hyper- than in hypo-responders. Both strains showed a dietary-cholesterol-induced rise in plasma CETP as well as in PLTP activity. The increase in PLTP activity was greater in the hyper-responders, but that of CETP was less. There was no effect of dietary cholesterol on LCAT activity. It is hypothesized that the lipases are involved in the removal of cholesterol-rich lipoproteins.

scholarly journals Plasma Lipoproteins in Familial Lecithin:Cholesterol Acyltransferase Deficiency FURTHER STUDIES OF VERY LOW AND LOW DENSITY LIPOPROTEIN ABNORMALITIES

1973 ◽  
Vol 52 (5) ◽  
pp. 1078-1092 ◽  
Author(s):  
John A. Glomset ◽  
Alex V. Nichols ◽  
Kaare R. Norum ◽  
Weiling King ◽  
Trudy Forte
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Plasma Lipoproteins ◽  
Low Density ◽  
Lecithin:Cholesterol Acyltransferase

Plasma Lipoproteins in Familial Lecithin:Cholesterol Acyltransferase Deficiency: Effects of Dietary Manipulation

1975 ◽  
Vol 35 (sup142) ◽  
pp. 3-30 ◽  
Author(s):  
John A. Glomset ◽  
Kaare R. Norum ◽  
Alex V. Nichols ◽  
Weiling C. King ◽  
Carolyn D. Mitchell ◽  
...  
Keyword(s):  
Plasma Lipoproteins ◽  
Dietary Manipulation ◽  
Lecithin:Cholesterol Acyltransferase

scholarly journals Regulation of sterol transport in human microvascular endothelial cells.

1982 ◽  
Vol 94 (2) ◽  
pp. 350-354 ◽  
Author(s):  
P E Fielding ◽  
P M Davison ◽  
M A Karasek ◽  
C J Fielding
Keyword(s):  
Endothelial Cells ◽  
Human Plasma ◽  
Free Sterol ◽  
High Rate ◽  
Plasma Lipoproteins ◽  
Microvascular Endothelial Cells ◽  
Lecithin:Cholesterol Acyltransferase ◽  
Sterol Transport ◽  
The Face ◽  
Equivalent Conditions

In cultured human dermal microvessel endothelial cells, the rate of efflux (about twofold greater than for fibroblasts under equivalent conditions) was coupled to an equivalent high rate of sterol net transport from the cells to the medium. This net transport was linked with esterification via lecithin:cholesterol acyltransferase. Since the use of free sterol by plasma transferase is constant, such increased net transport indicates that endothelial cells are highly efficient, in competition with plasma lipoproteins, in supplying free sterol for esterification. These results indicate the marked ability of endothelial cells to regulate and maintain their sterol balance in the face of high sterol levels to which these cells are uniquely exposed in human plasma.

scholarly journals Plasma lipoproteins and lecithin:cholesterol acyltransferase distribution in patients on dialysis

1984 ◽  
Vol 25 (4) ◽  
pp. 683-688 ◽  
Author(s):  
Roger McLeod ◽  
C. Edward Reeve ◽  
Jiri Frohlich
Keyword(s):  
Plasma Lipoproteins ◽  
Lecithin:Cholesterol Acyltransferase
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