scholarly journals Targeted proteomics for evaluating risk of venous thrombosis following traumatic lower‐leg injury or knee arthroscopy

2021 ◽  
Author(s):  
Yassene Mohammed ◽  
Carolina E. Touw ◽  
Banne Nemeth ◽  
Raymond A. Adrichem ◽  
Christoph H. Borchers ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Knee Arthroscopy ◽  
Lower Leg ◽  
Targeted Proteomics

scholarly journals A Rare Case of Pre-Existing Deep Venous Thrombosis in the Peroneal Vein of a Free Osteocutaneous Fibula Flap

2018 ◽  
Vol 03 (02) ◽  
pp. e74-e77
Author(s):  
Satoshi Hayashi ◽  
Kenji Kawamura ◽  
Naoki Maegawa ◽  
Akito Nakanishi ◽  
Yasushi Mizutani ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Preoperative Evaluation ◽  
Skin Grafting ◽  
Lower Leg ◽  
Medical Problem ◽  
Skin Paddle ◽  
Fibula Flap ◽  
Initial Surgery ◽  
Segmental Bone

Background Deep venous thrombosis (DVT) of the lower leg is a widespread medical problem and is associated with hypercoagulable states. Although spontaneous thrombosis of the peroneal vein of a fibula flap is theoretically possible, few cases of asymptomatic DVT of the peroneal vein encountered during fibula flap harvest have been reported. Case Report A 45-year-old man presented with segmental bone defects of the tibia resulting from a fall. Treatment with a free vascularized osteocutaneous fibula flap from the contralateral lower leg was scheduled. Intraoperatively, diffuse thrombi were found in the peroneal venous system. After removal of thrombi, the fibula was grafted with anastomosis of the peroneal vessels to the recipient posterior tibial vessels. The skin paddle of the flap became congested after surgery; exsanguination of the skin paddle was performed with multiple skin incisions to relieve congestion. Despite treatment, the skin paddle became partially necrotic and additional skin grafting was performed. Bone union of the grafted fibula was achieved 5 months after initial surgery. Conclusions To the best of our knowledge, only six cases of pre-existing DVT in the peroneal vein of a free osteocutaneous fibula flap have been reported. In three of these cases, the fibula flap was successfully grafted. Although successful free osteocutaneous fibula flap surgery might be possible in patients with peroneal venous thrombosis, careful preoperative evaluation is recommended for high-risk patients.

Deep Venous Thrombosis After Knee Arthroscopy: A Systematic Review and Meta-Analysis

2014 ◽  
Vol 30 (3) ◽  
pp. 406-412 ◽  
Author(s):  
Ye Sun ◽  
Dongyang Chen ◽  
Zhihong Xu ◽  
Dongquan Shi ◽  
Jin Dai ◽  
...  
Keyword(s):  
Systematic Review ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Knee Arthroscopy ◽  
Meta Analysis

Thromboprophylaxis after knee arthroscopy and lower leg casting

VASA ◽  
2017 ◽  
Vol 46 (4) ◽  
pp. 319-320
Keyword(s):  
Knee Arthroscopy ◽  
Lower Leg

scholarly journals High risk of recurrent venous thrombosis in patients with lower-leg cast immobilization

2018 ◽  
Vol 16 (11) ◽  
pp. 2218-2222 ◽  
Author(s):  
B. Nemeth ◽  
J. F. Timp ◽  
A. van Hylckama Vlieg ◽  
F. R. Rosendaal ◽  
S. C. Cannegieter
Keyword(s):  
High Risk ◽  
Venous Thrombosis ◽  
Lower Leg ◽  
Cast Immobilization ◽  
Recurrent Venous Thrombosis

scholarly journals Venous Thrombosis Risk after Arthroscopy of the Knee: Derivation and Validation of the L-TRiP(ascopy) Score

2018 ◽  
Vol 118 (10) ◽  
pp. 1823-1831 ◽  
Author(s):  
Banne Nemeth ◽  
Raymond van Adrichem ◽  
Astrid van Hylckama Vlieg ◽  
Trevor Baglin ◽  
Frits Rosendaal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Case Control Study ◽  
Knee Arthroscopy ◽  
External Validation ◽  
Case Control ◽  
Complete Model ◽  
Predictive Values ◽  
Thrombosis Risk ◽  
Control Study

AbstractPatients at high risk for venous thrombosis (VT) following knee arthroscopy could potentially benefit from thromboprophylaxis. We explored the predictive values of environmental, genetic risk factors and levels of coagulation markers to integrate these into a prediction model. Using a population-based case–control study into the aetiology of VT, we developed a Complete (all variables), Screening (easy to use in clinical practice) and Clinical (only environmental risk factors) model. The Clinical model was transformed into the Leiden-Thrombosis Risk Prediction (arthroscopy) score [L-TRiP(ascopy) score]. Model validation was performed both internally and externally in another case–control study. A total of 4,943 cases and 6,294 controls were maintained in the analyses, 107 cases and 26 controls had undergone knee arthroscopy. Twelve predictor variables (8 environmental, 3 haemorheological and 1 genetic) were selected from 52 candidates and incorporated into the Complete model (area under the curve [AUC] of 0.81, 95% confidence interval [CI], 0.76–0.86). The Screening model (9 predictors: environmental factors plus factor VIII activity) reached an AUC of 0.76 (95% CI, 0.64–0.88) and the Clinical (and corresponding L-TRiP(ascopy)) model an AUC of 0.72 (95% CI, 0.60–0.83). In the internal and external validation, the Complete model reached an AUC of 0.78 (95% CI, 0.52–0.98) and 0.75 (95% CI, 0.42–1.00), respectively, while the other models performed slightly less well.

Does deep venous thrombosis prophylaxis benefit patients with lower-leg immobilization?

2019 ◽  
Vol 22 (1) ◽  
pp. 23-24
Author(s):  
Michael R. Downs ◽  
Dhara Patel ◽  
Olena Romenska
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Lower Leg ◽  
Thrombosis Prophylaxis ◽  
Deep Venous Thrombosis Prophylaxis
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