Pharmacokinetics of levofloxacin mesylate in healthy adult giant panda after single‐dose administration via different routes

2021 ◽  
Author(s):  
Chengdong Wang ◽  
Linhua Deng ◽  
Yanqiu Zhu ◽  
Kai Wu ◽  
Ming Wei ◽  
...  
Keyword(s):  
Single Dose ◽  
Giant Panda ◽  
Healthy Adult ◽  
Dose Administration ◽  
Single Dose Administration

scholarly journals Efficacy and Safety of Mizoribine by One Single Dose Administration for Patients with Rheumatoid Arthritis

2010 ◽  
Vol 49 (20) ◽  
pp. 2211-2218 ◽  
Author(s):  
Kunihiro Ichinose ◽  
Tomoki Origuchi ◽  
Shin-ya Kawashiri ◽  
Naoki Iwamoto ◽  
Keita Fujikawa ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Single Dose ◽  
Efficacy And Safety ◽  
Dose Administration ◽  
Single Dose Administration

scholarly journals Pharmacokinetics and Safety of Intravenous Ceftolozane-Tazobactam in Healthy Adult Subjects following Single and Multiple Ascending Doses

2012 ◽  
Vol 56 (6) ◽  
pp. 3086-3091 ◽  
Author(s):  
Benjamin Miller ◽  
Ellie Hershberger ◽  
David Benziger ◽  
MyMy Trinh ◽  
Ian Friedland
Keyword(s):  
Single Dose ◽  
Adverse Events ◽  
Healthy Adult ◽  
Volume Of Distribution ◽  
Dose Administration ◽  
Mean Values ◽  
Multiple Doses ◽  
Dosing Regimens ◽  
Dose Levels ◽  
Dose Limiting Toxicity

ABSTRACTThe pharmacokinetics and safety of ceftolozane, a novel cephalosporin, and tazobactam, a β-lactamase inhibitor, alone and in combination as a 2:1 ratio in single doses of up to 2,000 and 1,000 mg of ceftolozane and tazobactam, respectively, and multiple doses of up to 3,000 and 1,500 mg of ceftolozane and tazobactam, respectively, per day were evaluated in healthy adult subjects. In part 1, groups of six subjects each received single ascending doses of ceftolozane, tazobactam, and ceftolozane-tazobactam in a within-cohort crossover design. In part 2, groups of 5 or 10 subjects each received multiple doses of ceftolozane, tazobactam, or ceftolozane-tazobactam for 10 days. After a single dose of ceftolozane alone, the ranges of mean values for half-life (2.48 to 2.64 h), the total clearance (4.35 to 6.01 liters/h), and the volume of distribution at steady state (11.0 to 14.1 liters) were consistent across dose levels and similar to those observed when ceftolozane was coadministered with tazobactam. Mean values after multiple doses for ceftolozane alone and ceftolozane-tazobactam were similar to those seen following a single dose. The pharmacokinetics of the dosing regimens evaluated were dose proportional and linear. Ceftolozane-tazobactam was well tolerated and systemic adverse events were uncommon. Mild infusion-related adverse events were the most commonly observed following multiple-dose administration. Adverse events were not dose related, and no dose-limiting toxicity was identified.

Biological response genes after single dose administration of interferon β-1b to healthy male volunteers

2008 ◽  
Vol 199 (1-2) ◽  
pp. 115-125 ◽  
Author(s):  
Jan Hilpert ◽  
Johanna M. Beekman ◽  
Susanne Schwenke ◽  
Kristin Kowal ◽  
David Bauer ◽  
...  
Keyword(s):  
Single Dose ◽  
Biological Response ◽  
Healthy Male ◽  
Interferon Β ◽  
Dose Administration ◽  
Single Dose Administration ◽  
Healthy Male Volunteers ◽  
Male Volunteers

scholarly journals Pharmacokinetic study of a slow-release preparation of sodium valproate(KW-6066N). Single dose administration test and the effects of food on valproate absorption.

1988 ◽  
Vol 6 (2) ◽  
pp. 196-203 ◽  
Author(s):  
Akio Takeda ◽  
Junko Inaguma ◽  
Akiko Shimizu ◽  
Shin-ichi Terao ◽  
Katsuo Amioka ◽  
...  
Keyword(s):  
Single Dose ◽  
Sodium Valproate ◽  
Pharmacokinetic Study ◽  
Slow Release ◽  
Dose Administration ◽  
Single Dose Administration ◽  
Release Preparation ◽  
Slow Release Preparation
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