Population genomic scans suggest novel genes underlie convergent flowering time evolution in the introduced range ofArabidopsis thaliana

2016 ◽  
Vol 26 (1) ◽  
pp. 92-106 ◽  
Author(s):  
Billie A. Gould ◽  
John R. Stinchcombe
Keyword(s):  
Flowering Time ◽  
Time Evolution ◽  
Novel Genes ◽  
Population Genomic ◽  
Ofarabidopsis Thaliana ◽  
Introduced Range ◽  
Genomic Scans

Evaluating Population Genomic Candidate Genes Underlying Flowering Time in Arabidopsis thaliana Using T-DNA Insertion Lines

2019 ◽  
Vol 110 (4) ◽  
pp. 445-454 ◽  
Author(s):  
Veronica K Chong ◽  
John R Stinchcombe
Keyword(s):  
Arabidopsis Thaliana ◽  
Flowering Time ◽  
Candidate Genes ◽  
Insertional Mutagenesis ◽  
Knock Out ◽  
Population Genomic ◽  
Outlier Loci ◽  
Genomic Studies ◽  
Dna Insertion ◽  
Genomic Scans

Abstract Population genomic scans have emerged as a powerful tool to detect regions of the genome that are potential targets of selection. Despite the success of genomic scans in identifying novel lists of loci potentially underlying adaptation, few studies proceed to validate the function of these candidate genes. In this study, we used transfer-DNA (T-DNA) insertion lines to evaluate the effects of 27 candidate genes on flowering time in North American accessions of Arabidopsis thaliana. We compared the flowering time of T-DNA insertion lines that knock out the function of a candidate gene obtained from population genomic studies to a wild type under long- and short-day conditions. We also did the same for a collection of randomly chosen genes that had not been identified as candidates. We validated the well-known effect of long-day conditions in accelerating flowering time and found that gene disruption caused by insertional mutagenesis tends to delay flowering. Surprisingly, we found that knockouts in random genes were just as likely to produce significant phenotypic effects as knockouts in candidate genes. T-DNA insertions at a handful of candidate genes that had previously been identified as outlier loci showed significant delays in flowering time under both long and short days, suggesting that they are promising candidates for future investigation.

scholarly journals Water availability as an agent of selection in introduced populations ofArabidopsis thaliana: impacts on flowering time evolution

PeerJ ◽  
2015 ◽  
Vol 3 ◽  
pp. e898 ◽  
Author(s):  
Amanda J. Stock ◽  
Brechann V. McGoey ◽  
John R. Stinchcombe
Keyword(s):  
Flowering Time ◽  
Time Evolution ◽  
Water Availability ◽  
Introduced Populations ◽  
Ofarabidopsis Thaliana

scholarly journals Genetic architecture of flowering time differentiation between locally adapted populations ofArabidopsis thaliana

2013 ◽  
Vol 197 (4) ◽  
pp. 1321-1331 ◽  
Author(s):  
Michael A. Grillo ◽  
Changbao Li ◽  
Mark Hammond ◽  
Lijuan Wang ◽  
Douglas W. Schemske
Keyword(s):  
Flowering Time ◽  
Genetic Architecture ◽  
Ofarabidopsis Thaliana

scholarly journals Adaptive divergence in flowering time among natural populations ofArabidopsis thaliana: Estimates of selection and QTL mapping

Evolution ◽  
2016 ◽  
Vol 71 (3) ◽  
pp. 550-564 ◽  
Author(s):  
Jon Ågren ◽  
Christopher G. Oakley ◽  
Sverre Lundemo ◽  
Douglas W. Schemske
Keyword(s):  
Qtl Mapping ◽  
Flowering Time ◽  
Natural Populations ◽  
Adaptive Divergence ◽  
Ofarabidopsis Thaliana

scholarly journals Flowering time evolution is independent of serpentine tolerance in the California flora

Ecosphere ◽  
2017 ◽  
Vol 8 (4) ◽  
Author(s):  
Adam Schneider
Keyword(s):  
Flowering Time ◽  
Time Evolution ◽  
California Flora

AtMBD8is involved in control of flowering time in the C24 ecotype ofArabidopsis thaliana

2009 ◽  
Vol 136 (1) ◽  
pp. 110-126 ◽  
Author(s):  
Biljana Stangeland ◽  
E. Maryann Rosenhave ◽  
Per Winge ◽  
Anita Berg ◽  
Silja S. Amundsen ◽  
...  
Keyword(s):  
Flowering Time ◽  
Ofarabidopsis Thaliana

scholarly journals Population genomic scans reveal novel genes underlie convergent flowering time evolution in the introduced range of Arabidopsis thaliana

2015 ◽  
Author(s):  
Billie Gould ◽  
John R Stinchcombe
Keyword(s):  
Arabidopsis Thaliana ◽  
Flowering Time ◽  
Evolutionary Biology ◽  
Parallel Evolution ◽  
Native Range ◽  
Genetic Components ◽  
Introduced Range ◽  
Selection For ◽  
Native And Introduced Ranges ◽  
High Degree

A long-standing question in evolutionary biology is whether the evolution of convergent phenotypes results from selection on the same heritable genetic components. Using whole genome sequencing and genome scans, we tested whether the evolution of parallel longitudinal flowering time clines in the native and introduced ranges of Arabidopsis thaliana has a similar genetic basis. We found that common variants of large effect on flowering time in the native range do not appear to have been under recent strong selection in the introduced range. Genes in regions of the genome that are under selection for flowering time are also not enriched for functions related to development or environmental sensing. We instead identified a set of 53 new candidate genes putatively linked to the evolution of flowering time in the species introduced range. A high degree of conditional neutrality of flowering time variants between the native and introduced range may preclude parallel evolution at the level of genes. Overall, neither gene pleiotropy nor available standing genetic variation appears to have restricted the evolution of flowering time in the introduced range to high frequency variants from the native range or to known flowering time pathway genes.

951: TOB1 and ID-1 Two Novel Genes Implicated in Bladder Cancer Progression and Prognosis

2004 ◽  
Vol 171 (4S) ◽  
pp. 252-252
Author(s):  
Paul Perrotte ◽  
Nadia Benachenou ◽  
Pierre I. Karakiewicz ◽  
Myriam Senay ◽  
Fred Saad
Keyword(s):  
Bladder Cancer ◽  
Cancer Progression ◽  
Novel Genes
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