Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells

2017 ◽  
Vol 43 (7) ◽  
pp. 584-603 ◽  
Author(s):  
M.-Y. Son ◽  
H. Sim ◽  
Y. S. Son ◽  
K. B. Jung ◽  
M.-O. Lee ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Disease Patient ◽  
Genomic Signature ◽  
Intestinal Organoids ◽  
Induced Pluripotent ◽  
Familial Parkinson’S Disease

scholarly journals Generation of induced pluripotent stem cells from a young-onset Parkinson's disease patient carrying the compound heterozygous PLA2G6 p.D331Y/p.M358IfsX mutations

2019 ◽  
Vol 40 ◽  
pp. 101552
Author(s):  
Ching-Chi Chiu ◽  
Hung-Li Wang ◽  
Yi-Hsin Weng ◽  
Rou-Shayn Chen ◽  
Chiung-Mei Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Disease Patient ◽  
Compound Heterozygous ◽  
Young Onset ◽  
Induced Pluripotent

scholarly journals Generation of induced pluripotent stem cells (NIMHi001-A) from a Parkinson's disease patient of East Indian ethnicity carrying LRRK2 I1371V variant

2020 ◽  
Vol 44 ◽  
pp. 101768 ◽  
Author(s):  
Indrani Datta ◽  
Sowmithra ◽  
Soham Jagtap ◽  
Chandrakanta Potdar ◽  
Ravi Yadav ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Disease Patient ◽  
East Indian ◽  
Induced Pluripotent

scholarly journals Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

Cell ◽  
2009 ◽  
Vol 137 (7) ◽  
pp. 1356 ◽  
Author(s):  
Frank Soldner ◽  
Dirk Hockemeyer ◽  
Caroline Beard ◽  
Qing Gao ◽  
George W. Bell ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Disease Patient ◽  
Reprogramming Factors ◽  
Induced Pluripotent

In Vivo Phenotyping of Familial Parkinson’s Disease with Human Induced Pluripotent Stem Cells: A Proof-of-Concept Study

2019 ◽  
Vol 44 (6) ◽  
pp. 1475-1493 ◽  
Author(s):  
Ourania Zygogianni ◽  
Nasia Antoniou ◽  
Maria Kalomoiri ◽  
Georgia Kouroupi ◽  
Era Taoufik ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Proof Of Concept ◽  
Concept Study ◽  
Induced Pluripotent ◽  
Familial Parkinson’S Disease

scholarly journals Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

Cell ◽  
2009 ◽  
Vol 136 (5) ◽  
pp. 964-977 ◽  
Author(s):  
Frank Soldner ◽  
Dirk Hockemeyer ◽  
Caroline Beard ◽  
Qing Gao ◽  
George W. Bell ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Disease Patient ◽  
Reprogramming Factors ◽  
Induced Pluripotent

scholarly journals Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Vasiliki Panagiotakopoulou ◽  
Dina Ivanyuk ◽  
Silvia De Cicco ◽  
Wadood Haq ◽  
Aleksandra Arsić ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Neuronal Loss ◽  
Interferon Γ ◽  
Independent Manner ◽  
Ifn Γ ◽  
Induced Pluripotent

Abstract Parkinson’s disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopaminergic neurons and microglia differentiated from patient-derived induced pluripotent stem cells carrying LRRK2 G2019S, the most common Parkinson’s disease-associated mutation. We show that IFN-γ enhances the LRRK2 G2019S-dependent negative regulation of AKT phosphorylation and NFAT activation, thereby increasing neuronal vulnerability to immune challenge. Mechanistically, LRRK2 G2019S suppresses NFAT translocation via calcium signaling and possibly through microtubule reorganization. In microglia, LRRK2 modulates cytokine production and the glycolytic switch in response to IFN-γ in an NFAT-independent manner. Activated LRRK2 G2019S microglia cause neurite shortening, indicating that LRRK2-driven immunological changes can be neurotoxic. We propose that synergistic LRRK2/IFN-γ activation serves as a potential link between inflammation and neurodegeneration in Parkinson’s disease.

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