scholarly journals Patient‐Specific Analysis of Neural Activation During Spinal Cord Stimulation for Pain

2019 ◽  
Vol 23 (5) ◽  
pp. 572-581 ◽  
Author(s):  
Scott F. Lempka ◽  
Hans J. Zander ◽  
Carlos J. Anaya ◽  
Alexandria Wyant ◽  
John G. Ozinga ◽  
...  
2021 ◽  
Vol 10 (18) ◽  
pp. 4085
Author(s):  
Jan Kallewaard ◽  
Jose Paz-Solis ◽  
Pasquale De Negri ◽  
Maria Canós-Verdecho ◽  
Hayat Belaid ◽  
...  

Given the differing mechanisms thought to underlie therapeutic sub- and supra-perception-based neurostimulative modalities, Spinal Cord Stimulation (SCS) systems designed for combined delivery of these approaches may help improve analgesic outcomes and quality of life, and reduce treatment failures. This multicenter, observational case-series evaluated 188 patients with chronic back and/or leg pain implanted with an SCS device capable of sequential or simultaneous delivery of sub-perception and supra-perception stimulation programming (i.e., combination therapy) at 16 sites in Europe. Following implantation, patients were provided with an array of advanced supra-perception programs (e.g., paresthesia-based SCS using multiple independent current sources), and a custom set of sub-perception programs optimized with specific waveforms and/or field shapes. A mean overall pain score of 7.9 ± 1.7 (Standard Deviation (SD)) was reported pre-trial (Baseline). Overall pain was reduced by 4.4 ± 2.8 points (NRS) at 3-months (n = 117) and at 12 months post-implant (n = 90), respectively (p < 0.0001). Substantial quality-of-life (EQ-5D-5L) improvement as assessed at last follow-up was also observed (n = 60). These results suggest that an implanted SCS device capable of combination therapy, while also enabled with patient-specific waveform optimization and stimulation field targeting capabilities, can enable highly effective pain relief and improve quality of life in patients suffering with chronic pain.


2016 ◽  
Vol 17 (4) ◽  
pp. S74
Author(s):  
S. Lempka ◽  
J. Ozinga ◽  
A. Wyant ◽  
F. Dong ◽  
S. Jones ◽  
...  

2007 ◽  
Vol 8 (S2) ◽  
Author(s):  
Dongchul Lee ◽  
Michael Moffitt ◽  
Kerry Bradley ◽  
Dave Peterson

2020 ◽  
Author(s):  
A Kasapovic ◽  
D Schwetje ◽  
D Cucchi ◽  
M Gathen ◽  
M Jaenisch ◽  
...  

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