scholarly journals Critical evaluation of animal models of visceral pain for therapeutics development: A focus on irritable bowel syndrome

2019 ◽  
Vol 32 (4) ◽  
Author(s):  
Anthony C. Johnson ◽  
Adam D. Farmer ◽  
Timothy J. Ness ◽  
Beverley Greenwood‐Van Meerveld
Keyword(s):  
Irritable Bowel Syndrome ◽  
Animal Models ◽  
Visceral Pain ◽  
Critical Evaluation ◽  
Irritable Bowel ◽  
Therapeutics Development

scholarly journals Stress-Induced Visceral Pain: Toward Animal Models of Irritable-Bowel Syndrome and Associated Comorbidities

2015 ◽  
Vol 6 ◽  
Author(s):  
Rachel D. Moloney ◽  
Siobhain M. O’Mahony ◽  
Timothy G. Dinan ◽  
John F. Cryan
Keyword(s):  
Irritable Bowel Syndrome ◽  
Animal Models ◽  
Visceral Pain ◽  
Irritable Bowel

Recent advances in the pathophysiology of visceral pain in irritable bowel syndrome

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Eduardo E. Valdez-Morales ◽  
Tonatiuh Barrios-García ◽  
Alma Barajas-Espinosa ◽  
Raquel Guerrero Alba
Keyword(s):  
Irritable Bowel Syndrome ◽  
Visceral Pain ◽  
Recent Advances ◽  
Irritable Bowel

Mechanisms of stress-induced visceral pain in irritable bowel syndrome

2015 ◽  
Vol 61 ◽  
pp. 8-9
Author(s):  
María Vicario
Keyword(s):  
Irritable Bowel Syndrome ◽  
Visceral Pain ◽  
Irritable Bowel

Stress and visceral pain: Focusing on irritable bowel syndrome

Pain ◽  
2013 ◽  
Vol 154 ◽  
pp. S63-S70 ◽  
Author(s):  
Shin Fukudo
Keyword(s):  
Irritable Bowel Syndrome ◽  
Visceral Pain ◽  
Irritable Bowel

504 ENDOGENOUS MODULATION AND ANTICIPATION OF VISCERAL PAIN IN IRRITABLE BOWEL SYNDROME (IBS) ASSESSED BY HETEROTOPIC STIMULATION AND FUNCTIONAL BRAIN MRI

2006 ◽  
Vol 10 (S1) ◽  
pp. S133b-S133
Author(s):  
G.H. Song ◽  
C.H. Wilder-Smith ◽  
V. Venkatraman ◽  
K.Y. Ho ◽  
M. Chee ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Visceral Pain ◽  
Brain Mri ◽  
Functional Brain ◽  
Irritable Bowel

scholarly journals P2X3 Receptor in Primary Afferent Neurons Mediates the Relief of Visceral Hypersensitivity by Electroacupuncture in an Irritable Bowel Syndrome Rat Model

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Fang Zhang ◽  
Zhe Ma ◽  
Zhijun Weng ◽  
Min Zhao ◽  
Handan Zheng ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Rat Model ◽  
Visceral Pain ◽  
Visceral Hypersensitivity ◽  
Receptor Protein ◽  
Resting Membrane Potential ◽  
Drg Neurons ◽  
Expression Levels ◽  
Behavioral Studies ◽  
Irritable Bowel

Background. Electroacupuncture (EA) has been confirmed effectiveness in the treatment of irritable bowel syndrome (IBS), and P2X3 receptors in the peripheral and central neurons participate in the acupuncture-mediated relief of the visceral pain in IBS. Objective. To reveal the neurobiological mechanism that P2X3 receptor of colonic primary sensory neurons in the dorsal root ganglia of the lumbosacral segment is involved in the alleviation of visceral hypersensitivity by EA in an IBS rat model. Methods. The IBS chronic visceral pain rat model was established according to the method of Al-Chaer et al. EA at the bilateral He-Mu points, including ST25 and ST37, was conducted for intervention. The behavioral studies, histopathology of colon, electrophysiology, immunofluorescence histochemistry, and real-time polymerase chain reaction assays were used to observe the role of P2X3 receptor in the colon and related DRG in relieving visceral hypersensitivity by EA. Results. EA significantly reduced the behavior scores of the IBS rats under different levels (20, 40, 60, 80 mmHg) of colorectal distention stimulation and downregulated the expression levels of P2X3 receptor protein and mRNA in colon and related DRG of the IBS rats. EA also regulated the electrical properties of the membranes, including the resting membrane potential, rheobase, and action potential of colon-associated DRG neurons in the IBS rats. Conclusion. EA can regulate the P2X3 receptor protein and mRNA expression levels in the colon and related DRG of IBS rats with visceral pain and then regulate the excitatory properties of DRG neurons.

T1391 The Effect of Neurokinin-1 Receptor Antagonism On Central Responses to Visceral Pain in Irritable Bowel Syndrome (IBS): A Pilot Study

2008 ◽  
Vol 134 (4) ◽  
pp. A-545 ◽  
Author(s):  
Kirsten Tillisch ◽  
Joshua A. Bueller ◽  
Bruce D. Naliboff ◽  
Brandall Y. Suyenobu ◽  
Suzanne R. Smith ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pilot Study ◽  
Visceral Pain ◽  
Receptor Antagonism ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1 ◽  
Irritable Bowel

scholarly journals Mechanisms Underlying the Analgesic Effect of Moxibustion on Visceral Pain in Irritable Bowel Syndrome: A Review

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Renjia Huang ◽  
Jimeng Zhao ◽  
Luyi Wu ◽  
Chuanzi Dou ◽  
Huirong Liu ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Visceral Pain ◽  
Epidemiological Data ◽  
Neuroendocrine System ◽  
Functional Bowel Disorder ◽  
Number Of Patients ◽  
Potential Problems ◽  
Irritable Bowel ◽  
Bowel Disorder

Irritable bowel syndrome (IBS) is a functional bowel disorder that causes recurrent abdominal (visceral) pain. Epidemiological data show that the incidence rate of IBS is as high as 25%. Most of the medications may lead to tolerance, addiction and toxic side effects. Moxibustion is an important component of traditional Chinese medicine and has been used to treat IBS-like abdominal pain for several thousand years in China. As a mild treatment, moxibustion has been widely applied in clinical treatment of visceral pain in IBS. In recent years, it has played an irreplaceable role in alternative medicine. Extensive clinical studies have demonstrated that moxibustion for treatment of visceral pain is simple, convenient, and inexpensive, and it is being accepted by an increasing number of patients. There have not been many studies investigating the analgesic mechanisms of moxibustion. Studies exploring the analgesic mechanisms have mainly focused on visceral hypersensitivity, brain-gut axis neuroendocrine system, and immune system. This paper reviews the latest developments in moxibustion use for treatment of visceral pain in IBS from these perspectives. It also evaluates potential problems in relevant studies on the mechanisms of moxibustion therapy to promote the application of moxibustion in the treatment of IBS.

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