Colonic 5‐HT 4 receptors are targets for novel prokinetic drugs

2021 ◽  
Author(s):  
James J. Galligan
Keyword(s):  
Prokinetic Drugs

▾ Cisapride – more selective than metoclopramide

1990 ◽  
Vol 28 (23) ◽  
pp. 89-90
Keyword(s):  
Gastric Emptying ◽  
Gastrointestinal Motility ◽  
Chemical Structure ◽  
Sphincter Pressure ◽  
Antiemetic Effect ◽  
Gut Motility ◽  
Prokinetic Drugs ◽  
Similar Chemical ◽  
Non Ulcer Dyspepsia ◽  
Product Licence

Metoclopramide (Maxolon; Primperan), has been around for over 20 years and domperidone (Motilium - Sterling Winthrop) for eight years. Both are prokinetic drugs which speed gastric emptying, increase oesophageal sphincter pressure, stimulate gut motility and in addition have a central antiemetic effect. Cisapride (Prepulsid - Janssen; Alimix - Cilag) has a similar chemical structure to metoclopramide and is intended for the reduction of oesophageal reflux and relief of symptoms caused by impaired gastrointestinal motility. The product licence has recently been extended to include treatment of non-ulcer dyspepsia.

Comparing Longitudinal Overall and Individual Symptom Outcomes on Neuromodulator versus Prokinetic Drugs in Patients With Symptoms Suspicious for Gastroparesis but With Non—Delayed Gastric Emptying

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S686
Author(s):  
William Hasler ◽  
Baharak Moshiree ◽  
Richard McCallum ◽  
Satish S.C. Rao ◽  
Linda Nguyen ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Delayed Gastric Emptying ◽  
Prokinetic Drugs

Motilides and motilactides: Design and development of motilin receptor agonists as a new class of gastrointestinal prokinetic drugs

1998 ◽  
Vol 23 (8) ◽  
pp. 861 ◽  
Author(s):  
R. Faghih ◽  
H.N. Nellans ◽  
J.J. Plattner
Keyword(s):  
Design And Development ◽  
Prokinetic Drugs ◽  
Receptor Agonists ◽  
New Class ◽  
Motilin Receptor

Evidence-Based Use of Prokinetic Drugs for Abomasal Disorders in Cattle

2012 ◽  
Vol 28 (1) ◽  
pp. 51-70 ◽  
Author(s):  
Peter D. Constable ◽  
Mohammad Nouri ◽  
Ismail Sen ◽  
Aubrey N. Baird ◽  
Thomas Wittek
Keyword(s):  
Evidence Based ◽  
Prokinetic Drugs

scholarly journals Interaction of glimepiride with prokinetic drugs on some of gastrointestinal functions in STZ-induced diabetic mice

2013 ◽  
Vol 51 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Mohamed A. Fouad ◽  
Hekma A. Abd El latif ◽  
Mostafa E. El Sayed
Keyword(s):  
Diabetic Mice ◽  
Prokinetic Drugs

scholarly journals Interaction of insulin with prokinetic drugs in STZ-induced diabetic mice

2013 ◽  
Vol 4 (2) ◽  
pp. 28 ◽  
Author(s):  
Mohamed A Fouad Shalaby
Keyword(s):  
Diabetic Mice ◽  
Prokinetic Drugs

scholarly journals Human motilin transgenic mice are useful for evaluation of motilin receptor agonists as gastric prokinetic drugs

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO3-5-21
Author(s):  
Shinichi Kato ◽  
Aoi Takahashi ◽  
Mai Shindo ◽  
Kenjiro Matsumoto ◽  
Kikuko Amagase ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Prokinetic Drugs ◽  
Receptor Agonists ◽  
Motilin Receptor

Role of prokinetic drugs for treatment of postoperative ileus in the horse

1998 ◽  
Vol 76 (1) ◽  
pp. 25-31 ◽  
Author(s):  
AJ DART ◽  
DR HODGSON
Keyword(s):  
Postoperative Ileus ◽  
Prokinetic Drugs

Regulatory restrictions in prokinetic drugs: Phytotherapy to fill the gap left by cisapride, metoclopramide and domperidone in the therapy of functional gastrointestinal diseases

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
A Madisch ◽  
BR Vinson ◽  
H Abdel-Aziz ◽  
O Kelber ◽  
K Nieber ◽  
...  
Keyword(s):  
Gastrointestinal Diseases ◽  
Prokinetic Drugs ◽  
Functional Gastrointestinal Diseases

Prokinetic drugs for the treatment of constipation - predominant irritable bowel syndrome

2011 ◽  
Author(s):  
Valeria Mozetic de Barros ◽  
Álvaro N Atallah ◽  
Bernardo GO Soares
Keyword(s):  
Irritable Bowel Syndrome ◽  
Prokinetic Drugs ◽  
Irritable Bowel
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