Background: The most prevalent malignancy affect the urinary system is bladder cancer
which exhibits a markedly high recurrence rate. The level of urinary microRNA-146a
(miR-146a) was significantly higher in superficial bladder cancer patients, and were
decreased to normal range after transurethral resection of the bladder tumor (TUR-BT).
Its level was increased again if there is recurrence of the superficial bladder tumor
diagnosed by follow up cystoscopy. miR-146 may be a clinically important marker for
diagnosis and recurrence of superficial bladder cancer and is used instead of follow up
operations as follow up cystoscopy for follow up of recurrence . Objective: our work
aims to detect a simple, reliable and noninvasive diagnostic and surveillance methods
for follow up of superficial bladder cancer. Methodology: The level of miR-146a in
urine of 30 superficial bladder cancer patients was evaluated by quantitative reverse
transcription polymerase chain reaction assay using voided urine samples before, after
TUR-BT and after 3, 6,9,12 months of resection and compared with the result of follow
up cystoscopy. Results: miR-146a was significantly increased in urine samples from
patients with superficial cancer bladder than in those from the normal individuals (P
<.000). Elevated urinary miR-146a levels in patients with bladder cancer were lowered
to the normal level after TUR-BT and increased again in those who have tumor
recurrence and remain in a normal level in those who have no recurrence after follow
up for 3 ,6, 9,12 months after surgery(P=. 007, P=.000 respectively).Conclusion: Our
study concluded that urinary miR-146a may be useful as a novel noninvasive diagnostic
and follow up marker, anticancer agent or therapeutic target for superficial cancer
bladder, also for increasing our knowledge of cancer biology.
Effect of Age on Outcome of High-Risk Non-Muscle-Invasive Bladder Cancer Patients Treated with Second Transurethral Resection and Maintenance Bacillus Calmette-Guerin Therapy
