Author response for "Herbal Derivatives in the Management of Mouth Opening in Oral Submucous Fibrosis – A Network Meta‐Analysis"

Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition of the oral mucosa. It is characterized by excessive production of collagen leading to inelasticity of the oral mucosa and atrophic changes of the epithelium.Aim and objective: To evaluate the efficacy of oral Colchicine in comparison to intralesional injections of Dexamethasone plus Hyaluronidase in the management of OSMF patients.Materials and Methods: Fourty patients with OSMF were randomly divided equally into two groups. 20 patients in Dexamethasone group received biweekly intralesional injections of Dexamethasone (4mg/ml) plus Hyaluronidase 1500 IU in buccal mucosa for a period of 12 weeks. Other 20 patients in Colchicine group received oral Colchicine 0.5 mg tablets twice daily for 12 weeks. Parameters taken in the study were burning sensation, and mouth opening. Descriptive statistics, paired t test and unpaired t test were used for statistical analysis.Results and Conclusions: The pre- and post-treatment differences were found to be statistically significant for both the groups (p<0.001) and for both the treatment outcomes. When the average difference of the treatment outcomes was compared between the two study groups, statistically highly significant difference was noted (p <0.001) only in mouth opening but not in burning sensation.These encouraging results should prompt further clinical trials with Colchicine on a larger sample size to broaden the therapeutic usefulness of the drug in the management of OSMF. JNGMC, Vol. 14 No. 2 December 2016, Page: 60-65

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Effect of botulinum toxin-A on pain and mouth opening following surgical intervention in oral submucous fibrosis — a controlled clinical trial

Journal of Cranio-Maxillofacial Surgery ◽

10.1016/j.jcms.2021.01.019 ◽

2021 ◽

Author(s):

Saatvik Shandilya ◽

Sujata Mohanty ◽

Pankaj Sharma ◽

Zainab Chaudhary ◽

Sanchaita Kohli ◽

...

Keyword(s):

Clinical Trial ◽

Botulinum Toxin ◽

Surgical Intervention ◽

Botulinum Toxin A ◽

Oral Submucous Fibrosis ◽

Mouth Opening ◽

Controlled Clinical Trial ◽

Toxin A ◽

Submucous Fibrosis

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Comparison Of Collagen-Curcumin Blend (Collaper Rtu)With Intralesional Steroid Injections in Oral Submucous Fibrosis a Randomized, Open-Label Interventional Study.

10.21203/rs.3.rs-1214976/v1 ◽

2021 ◽

Author(s):

Bharat Kwatra ◽

Manya Pahwa

Keyword(s):

Oral Submucous Fibrosis ◽

Mouth Opening ◽

Burning Sensation ◽

Current Therapy ◽

Intralesional Injection ◽

Complete Regression ◽

Open Label ◽

Tongue Protrusion ◽

Interincisal Distance ◽

Submucous Fibrosis

Abstract Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition characterized by limited mouth opening, burning sensation, stiffness, and blanching of the oral mucosa induced by areca nut eating. With any of the current therapy regimens, complete regression of the illness has not been accomplished in all patients. Curcumin is a yellow pigment found in curry powder that has antioxidant, anti-inflammatory, and pro-apoptotic properties. As a result, interventional research was conducted to determine the efficacy of Collaper RTu a proprietary collagen-curcumin based product in patients with OSMF.Setting and design: Forty patients with clinically and histologically confirmed Oral Submucous Fibrosis participated in a randomized open label interventional research. Method & materials: For the research, forty patients with clinically and histologically verified Oral Submucous Fibrosis were randomly assigned to one of two groups. The first group was given a weekly intralesional injection of 4 mg Dexamethasone and 1500 I.U Hyaluronidase, whereas the second was given two Collagen-Curcumin pills (Collaper Rtu 60mg Collagen with 100 mg Curcumin) every day for three months. On a weekly basis, the improvement of burning sensation, interincisal distance, and tongue protrusion was assessed.Results: From early to late stages, the burning feeling improved in both groups. Collaper Rtu was found to eliminate the burning feeling. In groups 1 and 2, the mean increase in interincisal distance was 3.13 mm and 1.25 mm, respectively. The interincisal distance improved significantly in both groups by the end of the first month. When compared to group 2, group 1's tongue protrusion recovered faster at the conclusion of the first month. Conclusion: Collaper RTu is useful and effective in lowering the burning feeling in people with early OSMF.

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Immunohistochemical Analysis of Myofibroblasts Using α- SMA in Oral Submucous Fibrosis Turning into Malignancy- A Case Report and Review

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i52a33575 ◽

2021 ◽

pp. 192-198

Author(s):

Swapan Kumar Purkait ◽

. Abhinandan ◽

Nimisha Priya ◽

Sriyanshi Singh ◽

Sneha Singh

Keyword(s):

Case Report ◽

Immunohistochemical Study ◽

Oral Submucous Fibrosis ◽

Mouth Opening ◽

Immunohistochemical Analysis ◽

Invasive Front ◽

Premalignant Condition ◽

Submucous Fibrosis ◽

Very High ◽

Premalignant Conditions

Oral submucous fibrosis is a premalignant condition, characterized by fibrosis in oral mucosa causing stiffness of mucosa and leading to reduced mouth opening. The malignant transformation of oral submucous fibrosis is very high among the rest of the premalignant conditions. Chronic chewing of arecanut causes production of myofibroblasts. These myofibroblasts plays an important role in neoangiogenesis as well as disintegration of the basement membrane at the tumor invasive front leading to carcinoma. Here, we are doing an Immunohistochemical study using alpha SMA for proper microscopic visulizations of myofibroblastic activity in an OSF patient, encompassing the pathogenesis and malignant potentiality of the disease.

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