Malignant transformation of oral leukoplakia: systematic review and meta‐analysis of the last 5 years

Oral Diseases ◽  
2021 ◽  
Author(s):  
JM Aguirre‐Urizar ◽  
I Lafuente‐Ibáñez de Mendoza ◽  
S Warnakulasuriya
Oral Oncology ◽  
2020 ◽  
Vol 109 ◽  
pp. 104850
Author(s):  
Mariana de Pauli Paglioni ◽  
Cesar Augusto Migliorati ◽  
Isabel Schausltz Pereira Faustino ◽  
Bruno Augusto Linhares Almeida Mariz ◽  
Ana Luiza Oliveira Corrêa Roza ◽  
...  

Oral Diseases ◽  
2021 ◽  
Author(s):  
Pablo Ramos‐García ◽  
Miguel Ángel González‐Moles ◽  
Fernanda Weber Mello ◽  
Jose V. Bagan ◽  
Saman Warnakulasuriya

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jaffer A. Shariff ◽  
Athanasios I. Zavras

Objective. To perform a systematic review and meta-analysis on studies that assess malignant transformation rates (MTR) of oral epithelial dysplasia. Materials and Methods. This review was planned and conducted in accordance with the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. PubMed, EMBASE, Google Scholar, and Cochrane databases were screened to identify observational studies. Quality assessments were completed by two reviewers independently using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Pooled-malignant transformation rate (MTR) in person years, subgroup, sensitivity, and publication bias analysis were calculated using STATA 13.0 and Comprehensive Meta-Analysis software. Results. Sixteen observational cohort studies were identified with a total of 3708 participants from Asia, North America, and Europe. Analysis showed a MTR of 10.5% (pooled-MTR: 10.5, 95% CI: 3.7 to 17.3; fixed effect model, I2=0.0%; Q-value = 2.389; p>0.05) among patients with histologically confirmed oral epithelia dysplasia undergoing long-term follow-up. Higher MTR in person year were seen among the sever dysplastic cases (pooled-MTR: 14.4%, 95% CI: 5.3% to 23.5%), studies published in Europe (pooled-MTR: 12.6%, 95% CI: 8.0% to 24.3%), and retrospective studies (pooled-MTR: 11.0%, 95% CI: 2.2% to 19.9%). Conclusion. These studies show that oral epithelial dysplasia has a significant high rate of transformation to cancer.


Head & Neck ◽  
2019 ◽  
Vol 41 (9) ◽  
pp. 3395-3407 ◽  
Author(s):  
Pablo Ramos‐García ◽  
Miguel Ángel González‐Moles ◽  
Ángela Ayén ◽  
Lucía González‐Ruiz ◽  
José Antonio Gil‐Montoya ◽  
...  

Oral Oncology ◽  
2019 ◽  
Vol 96 ◽  
pp. 121-130 ◽  
Author(s):  
Miguel Ángel González-Moles ◽  
Isabel Ruiz-Ávila ◽  
Lucía González-Ruiz ◽  
Ángela Ayén ◽  
José Antonio Gil-Montoya ◽  
...  

2020 ◽  
Vol 8 (6) ◽  
pp. 488-498
Author(s):  
Rania Hassan Shalaby ◽  
◽  
Yehia Fathi ◽  
Basma Elsaadany ◽  
◽  
...  

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