Predictive value of CCND1 /cyclin D1 alterations in the malignant transformation of potentially malignant head and neck disorders: Systematic review and meta‐analysis

Head & Neck ◽  
2019 ◽  
Vol 41 (9) ◽  
pp. 3395-3407 ◽  
Author(s):  
Pablo Ramos‐García ◽  
Miguel Ángel González‐Moles ◽  
Ángela Ayén ◽  
Lucía González‐Ruiz ◽  
José Antonio Gil‐Montoya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cyclin D1 ◽  
Head And Neck ◽  
Malignant Transformation ◽  
Predictive Value ◽  
Meta Analysis ◽  
Potentially Malignant ◽  
Neck Disorders

Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta‐analysis of malignant transformation rate by subtype

Head & Neck ◽  
2019 ◽  
Vol 42 (3) ◽  
pp. 539-555 ◽  
Author(s):  
Oreste Iocca ◽  
Thomas P. Sollecito ◽  
Faizan Alawi ◽  
Gregory S. Weinstein ◽  
Jason G. Newman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oral Cavity ◽  
Malignant Transformation ◽  
Meta Analysis ◽  
Transformation Rate ◽  
Oral Dysplasia ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

scholarly journals Incidence of Oral Mucositis in Patients Undergoing Head and Neck Cancer Treatment: Systematic Review and Meta-Analysis

2021 ◽  
Vol 5 (1) ◽  
pp. 23
Author(s):  
Raquel Pacheco ◽  
Maria Alzira Cavacas ◽  
Paulo Mascarenhas ◽  
Pedro Oliveira ◽  
Carlos Zagalo
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Oral Health ◽  
Cancer Treatment ◽  
Head And Neck ◽  
Neck Cancer ◽  
Oral Mucositis ◽  
Negative Impact ◽  
Meta Analysis ◽  
Incidence Rates

This systematic review and meta-analysis aimed to assess the literature about the incidence of oral mucositis and its degrees (mild, moderate, and severe), in patients undergoing head and neck cancer treatment (radiotherapy, chemotherapy, and surgery). Addressing this issue is important since oral mucositis has a negative impact on oral health and significantly deteriorates the quality of life. Therefore, a multidisciplinary team, including dentists, should be involved in the treatment. The overall oral mucositis incidence was 89.4%. The global incidence for mild, moderate, and severe degrees were 16.8%, 34.5%, and 26.4%, respectively. The high incidence rates reported in this review point out the need for greater care in terms of the oral health of these patients.

Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta‐analysis

Oral Diseases ◽  
2021 ◽  
Author(s):  
Pablo Ramos‐García ◽  
Miguel Ángel González‐Moles ◽  
Fernanda Weber Mello ◽  
Jose V. Bagan ◽  
Saman Warnakulasuriya
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Meta Analysis ◽  
Proliferative Verrucous Leukoplakia

scholarly journals Mortality due to cancer treatment delay: systematic review and meta-analysis

BMJ ◽  
2020 ◽  
pp. m4087 ◽  
Author(s):  
Timothy P Hanna ◽  
Will D King ◽  
Stephane Thibodeau ◽  
Matthew Jalink ◽  
Gregory A Paulin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Overall Survival ◽  
Confidence Interval ◽  
Cancer Treatment ◽  
Head And Neck ◽  
Adjuvant Radiotherapy ◽  
Systemic Treatment ◽  
Meta Analysis ◽  
Treatment Delay ◽  
Hazard Ratio

Abstract Objective To quantify the association of cancer treatment delay and mortality for each four week increase in delay to inform cancer treatment pathways. Design Systematic review and meta-analysis. Data sources Published studies in Medline from 1 January 2000 to 10 April 2020. Eligibility criteria for selecting studies Curative, neoadjuvant, and adjuvant indications for surgery, systemic treatment, or radiotherapy for cancers of the bladder, breast, colon, rectum, lung, cervix, and head and neck were included. The main outcome measure was the hazard ratio for overall survival for each four week delay for each indication. Delay was measured from diagnosis to first treatment, or from the completion of one treatment to the start of the next. The primary analysis only included high validity studies controlling for major prognostic factors. Hazard ratios were assumed to be log linear in relation to overall survival and were converted to an effect for each four week delay. Pooled effects were estimated using DerSimonian and Laird random effect models. Results The review included 34 studies for 17 indications (n=1 272 681 patients). No high validity data were found for five of the radiotherapy indications or for cervical cancer surgery. The association between delay and increased mortality was significant (P<0.05) for 13 of 17 indications. Surgery findings were consistent, with a mortality risk for each four week delay of 1.06-1.08 (eg, colectomy 1.06, 95% confidence interval 1.01 to 1.12; breast surgery 1.08, 1.03 to 1.13). Estimates for systemic treatment varied (hazard ratio range 1.01-1.28). Radiotherapy estimates were for radical radiotherapy for head and neck cancer (hazard ratio 1.09, 95% confidence interval 1.05 to 1.14), adjuvant radiotherapy after breast conserving surgery (0.98, 0.88 to 1.09), and cervix cancer adjuvant radiotherapy (1.23, 1.00 to 1.50). A sensitivity analysis of studies that had been excluded because of lack of information on comorbidities or functional status did not change the findings. Conclusions Cancer treatment delay is a problem in health systems worldwide. The impact of delay on mortality can now be quantified for prioritisation and modelling. Even a four week delay of cancer treatment is associated with increased mortality across surgical, systemic treatment, and radiotherapy indications for seven cancers. Policies focused on minimising system level delays to cancer treatment initiation could improve population level survival outcomes.

scholarly journals Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

Head & Neck ◽  
2018 ◽  
Vol 41 (4) ◽  
pp. 1122-1130 ◽  
Author(s):  
Oisín Bugter ◽  
Steffi E. M. van de Ven ◽  
Jose A. Hardillo ◽  
Marco J. Bruno ◽  
Arjun D. Koch ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Early Detection ◽  
Head And Neck ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Second Primary ◽  
Primary Tumors ◽  
Second Primary Tumors
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