Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta‐analysis

Oral Diseases ◽  
2021 ◽  
Author(s):  
Pablo Ramos‐García ◽  
Miguel Ángel González‐Moles ◽  
Fernanda Weber Mello ◽  
Jose V. Bagan ◽  
Saman Warnakulasuriya
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Meta Analysis ◽  
Proliferative Verrucous Leukoplakia

scholarly journals Oral Proliferative Verrucous Leukoplakia: Progression to Malignancy and Clinical Implications. Systematic Review and Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 4085
Author(s):  
Gaspare Palaia ◽  
Amelia Bellisario ◽  
Riccardo Pampena ◽  
Roberto Pippi ◽  
Umberto Romeo
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Verrucous Carcinoma ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Categorical Variables ◽  
Anatomical Site ◽  
Continuous Variables ◽  
Proliferative Verrucous Leukoplakia

Aim: The aim of the present systematic review was to investigate the risk of malignant transformation of proliferative verrucous leukoplakia (PVL). Materials and Methods: the search was carried out using a combination of terms (leukoplakia OR leucoplakia) AND (multifocal OR proliferative) on the following databases: PubMed, Scopus, Web of Science (WOS Core Collection), Cochrane Library, selecting only articles published since 1985 and in the English language. Demographic, disease-related, and follow-up data extracted from the studies included in the qualitative synthesis were combined. Weighted means ± standard deviations were calculated for continuous variables, while categorical variables were reported as frequencies and percentages. Dichotomous outcomes were expressed as odd ratios (ORs) with 95% confidence intervals (CIs). Odd ratios for individual studies were combined using a random-effects meta-analysis, conducted using Review Manager 5.4 Software (Cochrane Community, Oxford, England). Results: twenty-two articles were included, with a total of 699 PVL patients, undergoing a mean follow-up of 7.2 years. Sixty-six percent of patients were females, with a mean age of 70.2 years, and 33.3% were males, with a mean age of 59.6 years. Most patients were non-smokers and non-alcohol users, and the gingiva/alveolar ridge mucosa was the most involved anatomical site by both PVL appearance and malignant transformation. A total of 320 PVL patients developed oral verrucous carcinoma (OVC) or conventional oral squamous cell carcinoma (OSCC) because of malignant transformation of PVL lesions (45.8%). A statistically significant 3.8-fold higher risk of progression to conventional OSCC was found compared to OVC in PVL patients, with women being 1.7 times more likely to develop oral cancer than men, as a consequence of PVL progression. Moreover, a statistically significant higher likelihood of developing conventional OSCC in female PVL patients than in males was found. In 46.5% of patients with PVL malignant transformation, multiple carcinomas, in different oral sites, occurred during follow-up. Conclusions: PVL is an aggressive lesion, which, in a high percentage of cases (almost 50%), undergoes malignant transformation, mainly toward OSCC. The female gender is most affected, especially in the elderly, with a negative history for alcohol and tobacco consumption.

scholarly journals Malignant Transformation Rate in Patients Presenting Oral Epithelial Dysplasia: Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jaffer A. Shariff ◽  
Athanasios I. Zavras
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Observational Studies ◽  
Meta Analysis ◽  
Epithelial Dysplasia ◽  
High Rate ◽  
Transformation Rate ◽  
Oral Epithelial Dysplasia ◽  
Observational Cohort ◽  
Oral Epithelial

Objective. To perform a systematic review and meta-analysis on studies that assess malignant transformation rates (MTR) of oral epithelial dysplasia. Materials and Methods. This review was planned and conducted in accordance with the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. PubMed, EMBASE, Google Scholar, and Cochrane databases were screened to identify observational studies. Quality assessments were completed by two reviewers independently using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Pooled-malignant transformation rate (MTR) in person years, subgroup, sensitivity, and publication bias analysis were calculated using STATA 13.0 and Comprehensive Meta-Analysis software. Results. Sixteen observational cohort studies were identified with a total of 3708 participants from Asia, North America, and Europe. Analysis showed a MTR of 10.5% (pooled-MTR: 10.5, 95% CI: 3.7 to 17.3; fixed effect model, I2=0.0%; Q-value = 2.389; p>0.05) among patients with histologically confirmed oral epithelia dysplasia undergoing long-term follow-up. Higher MTR in person year were seen among the sever dysplastic cases (pooled-MTR: 14.4%, 95% CI: 5.3% to 23.5%), studies published in Europe (pooled-MTR: 12.6%, 95% CI: 8.0% to 24.3%), and retrospective studies (pooled-MTR: 11.0%, 95% CI: 2.2% to 19.9%). Conclusion. These studies show that oral epithelial dysplasia has a significant high rate of transformation to cancer.

Laser excision of oral leukoplakia: Does it affect recurrence and malignant transformation? A systematic review and meta-analysis

Oral Oncology ◽  
2020 ◽  
Vol 109 ◽  
pp. 104850
Author(s):  
Mariana de Pauli Paglioni ◽  
Cesar Augusto Migliorati ◽  
Isabel Schausltz Pereira Faustino ◽  
Bruno Augusto Linhares Almeida Mariz ◽  
Ana Luiza Oliveira Corrêa Roza ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Meta Analysis ◽  
Oral Leukoplakia ◽  
Laser Excision

Predictive value of CCND1 /cyclin D1 alterations in the malignant transformation of potentially malignant head and neck disorders: Systematic review and meta‐analysis

Head & Neck ◽  
2019 ◽  
Vol 41 (9) ◽  
pp. 3395-3407 ◽  
Author(s):  
Pablo Ramos‐García ◽  
Miguel Ángel González‐Moles ◽  
Ángela Ayén ◽  
Lucía González‐Ruiz ◽  
José Antonio Gil‐Montoya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cyclin D1 ◽  
Head And Neck ◽  
Malignant Transformation ◽  
Predictive Value ◽  
Meta Analysis ◽  
Potentially Malignant ◽  
Neck Disorders

Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis

Oral Oncology ◽  
2019 ◽  
Vol 96 ◽  
pp. 121-130 ◽  
Author(s):  
Miguel Ángel González-Moles ◽  
Isabel Ruiz-Ávila ◽  
Lucía González-Ruiz ◽  
Ángela Ayén ◽  
José Antonio Gil-Montoya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Oral Lichen

scholarly journals Proliferative verrucous leukoplakia and its tumor markers: Systematic review and meta‐analysis

Head & Neck ◽  
2018 ◽  
Vol 41 (5) ◽  
pp. 1499-1507 ◽  
Author(s):  
Mirjami Rintala ◽  
Tero Vahlberg ◽  
Tuula Salo ◽  
Jaana Rautava
Keyword(s):  
Systematic Review ◽  
Tumor Markers ◽  
Meta Analysis ◽  
Proliferative Verrucous Leukoplakia

Malignant transformation of oral leukoplakia: systematic review and meta‐analysis of the last 5 years

Oral Diseases ◽  
2021 ◽  
Author(s):  
JM Aguirre‐Urizar ◽  
I Lafuente‐Ibáñez de Mendoza ◽  
S Warnakulasuriya
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Meta Analysis ◽  
Oral Leukoplakia
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