Ranolazine as a Promising Treatment Option for Atrial Fibrillation: Electrophysiologic Mechanisms, Experimental Evidence, and Clinical Implications

2014 ◽  
Vol 37 (10) ◽  
pp. 1412-1420 ◽  
Author(s):  
NIKOLAOS FRAGAKIS ◽  
KONSTANTINOS C. KOSKINAS ◽  
VASSILIOS VASSILIKOS
Keyword(s):  
Atrial Fibrillation ◽  
Experimental Evidence ◽  
Treatment Option ◽  
Clinical Implications ◽  
Promising Treatment

Non-Pharmacological, Non-Ablative Approaches for the Treatment of Atrial Fibrillation: Experimental Evidence and Potential Clinical Implications

2010 ◽  
Vol 4 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Benjamin J. Scherlag ◽  
Hiroshi Nakagawa ◽  
Warren M. Jackman ◽  
Ralph Lazzara ◽  
Sunny S. Po
Keyword(s):  
Atrial Fibrillation ◽  
Experimental Evidence ◽  
Clinical Implications

scholarly journals CLINICAL IMPLICATIONS OF POSTOPERATIVE ATRIAL FIBRILLATION IN HYPERTROPHIC CARDIOMYOPATHY PATIENTS UNDERGOING SURGICAL MYECTOMY

2021 ◽  
Vol 77 (18) ◽  
pp. 534
Author(s):  
Sara Hoss ◽  
Mahdi Montazeri ◽  
Deacon Lee ◽  
Olga Katz ◽  
Cindy Chow ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Hypertrophic Cardiomyopathy ◽  
Postoperative Atrial Fibrillation ◽  
Clinical Implications ◽  
Surgical Myectomy

scholarly journals Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report

2017 ◽  
Vol 17 (2) ◽  
pp. 558-561 ◽  
Author(s):  
Juyoung Ryu ◽  
Kangwook Lee ◽  
Changmug Joe ◽  
JongCheon Joo ◽  
Namhun Lee ◽  
...  
Keyword(s):  
Case Report ◽  
Treatment Option ◽  
Carbohydrate Antigen ◽  
Klatskin Tumor ◽  
Preoperative Radiation ◽  
Noninvasive Treatment ◽  
Patients With Cancer ◽  
Radiofrequency Hyperthermia ◽  
Promising Treatment ◽  
Tomography Scan

Hyperthermia, which is a noninvasive treatment that causes tumor cells to become heated and that works in synergy with anticancer drugs and radiation therapy, is emerging as a promising treatment for patients with cancer. The purpose of this study is to report the efficacy of hyperthermia combined with chemotherapy (gemcitabine/cisplatin) for the treatment of a patient with unresectable cholangiocarcinoma. A 54-year-old man was diagnosed as hilar cholangiocarcinoma (Klatskin tumor) and was administered neoadjuvant and preoperative radiation with chemotherapy. However, because the treatment with radiation and chemotherapy was not successful, he decided to undergo hyperthermia combined with chemotherapy as a second treatment option. He was suffering from fatigue, dyspepsia, epigastralgia, and jaundice. Hyperthermia combined with chemotherapy was administered 32 times over a period of 4 months. The patient experienced no critical complications, and the patient’s condition improved, with the carbohydrate antigen 19-9 (CA 19-9) and the total bilirubin levels being relatively lowered. In addition, the computed tomography scan showed that the cholangiocarcinoma had not progressed. In conclusion, this case report suggests radiofrequency hyperthermia combined with chemotherapy may be a promising treatment option for patients with unresectable cholangiocarcinoma.

Reentrant excitation as a cause of cardiac arrhythmias

1978 ◽  
Vol 235 (1) ◽  
pp. H1-H17 ◽  
Author(s):  
A. L. Wit ◽  
P. F. Cranefield
Keyword(s):  
Myocardial Infarction ◽  
Atrial Fibrillation ◽  
Experimental Evidence ◽  
Cardiac Arrhythmias ◽  
Fiber Bundles ◽  
Atrial Arrhythmias ◽  
Ventricular Muscle ◽  
Av Node ◽  
Reentrant Excitation ◽  
Longitudinal Dissociation

Mechanisms that cause reentry were defined in rings of tissue cut from jellyfish as early as 1906 by Mayer. The concepts were developed by Mines and Garrey during the next 10 years. Lewis then tried to demonstrate that reentry caused atrial flutter. Lewis, Garrey, and later Moe also proposed that atrial fibrillation was caused by reentry. Rosenblueth provided additional experimental evidence that reentry could cause atrial arrhythmias after crushing the intercaval bridge of atrial muscle. Recent studies by Allessie using microelectrodes have provided detailed evidence for reentry in atrial tissue. Mines in 1913 also proposed that reentry could occur in the AV node. Scherf then introduced the concept of functional longitudinal dissociation as a cause of return extrasystoles and this was later shown to happen in the node by Moe and his colleagues. Reentry can also occur between atria and ventricles utilizing accessory connecting pathways. Schmitt and Erlanger in 1913 were the first to do experiments which indicated that reentry can also occur in the ventricles. Subsequently it was shown that reentry can occur in Purkinje fiber bundles. Reentry in ventricular muscle may also cause some of the arrhythmias that occur after myocardial infarction.

Rhythm control: surgical ablation

ESC CardioMed ◽  
2018 ◽  
pp. 2173-2177
Author(s):  
Chawannuch Ruaengsri ◽  
Matthew R. Schill ◽  
Richard B. Schuessler ◽  
Ralph J. Damiano
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Treatment Option ◽  
Surgical Procedures ◽  
Antiarrhythmic Drugs ◽  
Cardiac Surgical Procedures ◽  
Rhythm Control ◽  
Maze Procedure ◽  
Hybrid Procedures ◽  
Surgical Ablation

Surgical ablation for atrial fibrillation was introduced in 1987 and has since become well established as a treatment option for patients with symptomatic atrial fibrillation refractory to antiarrhythmic drugs and/or catheter ablation or patients who are having concomitant cardiac surgical procedures. The Cox–Maze procedure has been improved upon by modern variations using ablation devices. More limited ablation procedures and hybrid procedures have been introduced, but their efficacy requires further investigation.

scholarly journals Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19

2020 ◽  
pp. 110394
Author(s):  
Xiyuan Bai ◽  
Joseph Hippensteel ◽  
Alida Leavitt ◽  
James P. Maloney ◽  
David Beckham ◽  
...  
Keyword(s):  
Treatment Option ◽  
Promising Treatment ◽  
Alpha 1 Antitrypsin

Robotic partial nephrectomy: A promising treatment option for T1b and complex renal tumors?

2013 ◽  
Vol 39 (10) ◽  
pp. 1167 ◽  
Author(s):  
M. Borghesi ◽  
E. Brunocilla ◽  
R. Schiavina ◽  
G. Martorana
Keyword(s):  
Partial Nephrectomy ◽  
Treatment Option ◽  
Renal Tumors ◽  
Robotic Partial Nephrectomy ◽  
Promising Treatment
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