A multidrug and toxic compound extrusion (MATE) transporter modulates auxin levels in root to regulate root development and promotes aluminium tolerance

2019 ◽  
Vol 43 (3) ◽  
pp. 745-759 ◽  
Author(s):  
Neha Upadhyay ◽  
Debojyoti Kar ◽  
Sourav Datta
Keyword(s):  
Root Development ◽  
Aluminium Tolerance ◽  
Toxic Compound ◽  
Mate Transporter

scholarly journals Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion (MATE) transporter in Nicotiana tabacum

2009 ◽  
Vol 106 (7) ◽  
pp. 2447-2452 ◽  
Author(s):  
M. Morita ◽  
N. Shitan ◽  
K. Sawada ◽  
M. C. E. Van Montagu ◽  
D. Inze ◽  
...  
Keyword(s):  
Nicotiana Tabacum ◽  
Toxic Compound ◽  
Vacuolar Transport ◽  
Mate Transporter

Recent molecular breeding advances for improving aluminium tolerance in maize and sorghum.

2021 ◽  
pp. 318-324
Author(s):  
Claudia Teixeira Guimaraes ◽  
Jurandir Vieira de Magalhaes
Keyword(s):  
Target Genes ◽  
Acid Soils ◽  
Genetic Effect ◽  
Al Toxicity ◽  
Aluminium Tolerance ◽  
Al Tolerance ◽  
Toxic Compound ◽  
The World ◽  
Breeding Programmes ◽  
Wide Adaptation

Abstract Citrate transporters belonging to the multidrug and toxic compound extrusion (MATE) family of membrane transporters in sorghum and maize, SbMATE and ZmMATE1, respectively, play a major role in aluminium (Al) tolerance. However, these MATE members show regulatory differences, as well as peculiarities in their genetic effect and mode of action. These aspects, which are discussed in this chapter, have to be considered to design successful breeding programmes in order to achieve maximum Al tolerance and, consequently, to improve grain and biomass production in regions of the world with Al toxicity. As shown in this chapter, target genes with major effects and molecular tools are available for marker-assisted breeding for improving Al tolerance both in sorghum and maize. However, wide adaptation to acid soils should be sought by pyramiding genes controlling different traits such as drought tolerance, P acquisition, resistance to diseases and other stresses commonly found in each agroecological environment.

Involvement of the Multidrug and Toxic Compound Extrusion Transporter in Testosterone Release from Cultured Pig Leydig Cells

Pharmacology ◽  
2017 ◽  
Vol 100 (1-2) ◽  
pp. 31-39 ◽  
Author(s):  
Mitsuhiro Goda ◽  
Kana Oda ◽  
Atsuko Oda ◽  
Naoki Kobayashi ◽  
Masato Otsuka
Keyword(s):  
Chorionic Gonadotropin ◽  
Leydig Cells ◽  
Physiological Function ◽  
Immunohistochemical Analysis ◽  
Organic Cations ◽  
Toxic Compound ◽  
Testosterone Levels ◽  
Testosterone Secretion ◽  
Cimetidine Treatment ◽  
Mate Transporter

Testosterone is considered to be released from Leydig cells via passive diffusion because of its hydrophobicity; however, the exact mechanism underlying testosterone secretion and the transporter involved are both unknown. Multidrug and toxic compound extrusion (MATE) transporters are predominantly found in the kidneys and liver and are thought to function in the elimination of metabolic organic cations during the final step of excretion in the kidney. In contrast, mMATE2 has been shown to be predominantly expressed in testicular Leydig cells. Although the physiological function of mMATE2 in Leydig cells is unknown, we hypothesized that mMATE2 acts as a testosterone exporter and is responsible for the secretion of testosterone from Leydig cells. Therefore, in the present study, we investigated the involvement of the MATE transporter in testosterone secretion from pig Leydig cells. Immunohistochemical analysis with anti-pig MATE2 antiserum indicated that the MATE transporter is present in pig Leydig cells. Additionally, treatment with the MATE inhibitors cimetidine and pyrimethamine reduced the testosterone secretion from pig Leydig cells but increased the intracellular testosterone levels. Estradiol release and intracellular estradiol level induced by human chorionic gonadotropin (hCG) further increased with cimetidine treatment. These results indicated that testosterone produced by hCG treatment is secreted from Leydig cells via the MATE transporter; however, in the presence of cimetidine or pyrimethamine, this MATE transporter-mediated secretion was inhibited, resulting in increased intracellular testosterone levels and estradiol production in Leydig cells. Thus, the MATE transporter may be responsible for testosterone secretion from Leydig cells.

scholarly journals Involvement of the Leaf-Specific Multidrug and Toxic Compound Extrusion (MATE) Transporter Nt-JAT2 in Vacuolar Sequestration of Nicotine in Nicotiana tabacum

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e108789 ◽  
Author(s):  
Nobukazu Shitan ◽  
Shota Minami ◽  
Masahiko Morita ◽  
Minaho Hayashida ◽  
Shingo Ito ◽  
...  
Keyword(s):  
Nicotiana Tabacum ◽  
Toxic Compound ◽  
Mate Transporter ◽  
Vacuolar Sequestration

Experimental evaluation of toxicity and neuroparalitical actions of fire-resistant turbine oil «Turbomas»

2020 ◽  
pp. 684-684
Author(s):  
L. V. Lukovnikova ◽  
G. I. Sidorin
Keyword(s):  
Experimental Evaluation ◽  
Intact Skin ◽  
Toxic Compound ◽  
Turbine Oil ◽  
Mucous Membranes ◽  
Low Toxic

The article presents the results of a study of the toxicity of fire-resistant turbine oil «Turbomas «, a derivative of diphenyl-(n-tert-butylphenyl phosphate). According to toxicity parameters, «Turbomas» oil is characterized as a low-toxic compound, does not have neuroparalytic action, exhibits mild cumulative properties, does not irritate the skin and mucous membranes, penetrates intact skin,

Varietal difference of root development and starch accumulation on stem of tomato occurred by fruit thinning

Root Research ◽  
2012 ◽  
Vol 21 (2) ◽  
pp. 39-43 ◽  
Author(s):  
Akimasa Nakano ◽  
Ryo Matsuda ◽  
Masahumi Johkan ◽  
Katsumi Suzuki ◽  
Donghyuk Ahn ◽  
...  
Keyword(s):  
Root Development ◽  
Varietal Difference ◽  
Starch Accumulation ◽  
Fruit Thinning
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