A multidrug and toxic compound extrusion (MATE) transporter modulates auxin levels in root to regulate root development and promotes aluminium tolerance

Abstract Citrate transporters belonging to the multidrug and toxic compound extrusion (MATE) family of membrane transporters in sorghum and maize, SbMATE and ZmMATE1, respectively, play a major role in aluminium (Al) tolerance. However, these MATE members show regulatory differences, as well as peculiarities in their genetic effect and mode of action. These aspects, which are discussed in this chapter, have to be considered to design successful breeding programmes in order to achieve maximum Al tolerance and, consequently, to improve grain and biomass production in regions of the world with Al toxicity. As shown in this chapter, target genes with major effects and molecular tools are available for marker-assisted breeding for improving Al tolerance both in sorghum and maize. However, wide adaptation to acid soils should be sought by pyramiding genes controlling different traits such as drought tolerance, P acquisition, resistance to diseases and other stresses commonly found in each agroecological environment.

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Involvement of the Multidrug and Toxic Compound Extrusion Transporter in Testosterone Release from Cultured Pig Leydig Cells

Pharmacology ◽

10.1159/000460822 ◽

2017 ◽

Vol 100 (1-2) ◽

pp. 31-39 ◽

Cited By ~ 1

Author(s):

Mitsuhiro Goda ◽

Kana Oda ◽

Atsuko Oda ◽

Naoki Kobayashi ◽

Masato Otsuka

Keyword(s):

Chorionic Gonadotropin ◽

Leydig Cells ◽

Physiological Function ◽

Immunohistochemical Analysis ◽

Organic Cations ◽

Toxic Compound ◽

Testosterone Levels ◽

Testosterone Secretion ◽

Cimetidine Treatment ◽

Mate Transporter

Testosterone is considered to be released from Leydig cells via passive diffusion because of its hydrophobicity; however, the exact mechanism underlying testosterone secretion and the transporter involved are both unknown. Multidrug and toxic compound extrusion (MATE) transporters are predominantly found in the kidneys and liver and are thought to function in the elimination of metabolic organic cations during the final step of excretion in the kidney. In contrast, mMATE2 has been shown to be predominantly expressed in testicular Leydig cells. Although the physiological function of mMATE2 in Leydig cells is unknown, we hypothesized that mMATE2 acts as a testosterone exporter and is responsible for the secretion of testosterone from Leydig cells. Therefore, in the present study, we investigated the involvement of the MATE transporter in testosterone secretion from pig Leydig cells. Immunohistochemical analysis with anti-pig MATE2 antiserum indicated that the MATE transporter is present in pig Leydig cells. Additionally, treatment with the MATE inhibitors cimetidine and pyrimethamine reduced the testosterone secretion from pig Leydig cells but increased the intracellular testosterone levels. Estradiol release and intracellular estradiol level induced by human chorionic gonadotropin (hCG) further increased with cimetidine treatment. These results indicated that testosterone produced by hCG treatment is secreted from Leydig cells via the MATE transporter; however, in the presence of cimetidine or pyrimethamine, this MATE transporter-mediated secretion was inhibited, resulting in increased intracellular testosterone levels and estradiol production in Leydig cells. Thus, the MATE transporter may be responsible for testosterone secretion from Leydig cells.

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Faculty Opinions recommendation of Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion (MATE) transporter in Nicotiana tabacum.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1157146.617256 ◽

2009 ◽

Author(s):

Ekkehard Neuhaus

Keyword(s):

Nicotiana Tabacum ◽

Toxic Compound ◽

Vacuolar Transport ◽

Mate Transporter

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Involvement of the Leaf-Specific Multidrug and Toxic Compound Extrusion (MATE) Transporter Nt-JAT2 in Vacuolar Sequestration of Nicotine in Nicotiana tabacum

PLoS ONE ◽

10.1371/journal.pone.0108789 ◽

2014 ◽

Vol 9 (9) ◽

pp. e108789 ◽

Cited By ~ 29

Author(s):

Nobukazu Shitan ◽

Shota Minami ◽

Masahiko Morita ◽

Minaho Hayashida ◽

Shingo Ito ◽

...

Keyword(s):

Nicotiana Tabacum ◽

Toxic Compound ◽

Mate Transporter ◽

Vacuolar Sequestration

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Preceding the root development – molecular regulation of proliferative activity in stem cell niche of human tooth germ cervical loops

10.26226/morressier.5ac383212afeeb00097a3cce ◽

2018 ◽

Author(s):

Darko Kero

Keyword(s):

Stem Cell ◽

Root Development ◽

Proliferative Activity ◽

Stem Cell Niche ◽

Tooth Germ ◽

Molecular Regulation ◽

Human Tooth ◽

Human Tooth Germ ◽

Cell Niche

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Experimental evaluation of toxicity and neuroparalitical actions of fire-resistant turbine oil «Turbomas»

Russian Journal of Occupational Health and Industrial Ecology ◽

10.31089/1026-9428-2019-59-9-684-685 ◽

2020 ◽

pp. 684-684

Author(s):

L. V. Lukovnikova ◽

G. I. Sidorin

Keyword(s):

Experimental Evaluation ◽

Intact Skin ◽

Toxic Compound ◽

Turbine Oil ◽

Mucous Membranes ◽

Low Toxic

The article presents the results of a study of the toxicity of fire-resistant turbine oil «Turbomas «, a derivative of diphenyl-(n-tert-butylphenyl phosphate). According to toxicity parameters, «Turbomas» oil is characterized as a low-toxic compound, does not have neuroparalytic action, exhibits mild cumulative properties, does not irritate the skin and mucous membranes, penetrates intact skin,

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