Novel three‐way complex rearrangement of TRPM1‐PUM1 ‐ LCK in a case of agminated Spitz nevi arising in a giant congenital hyperpigmented macule

2020 ◽  
Vol 33 (5) ◽  
pp. 767-772
Author(s):  
Keisuke Goto ◽  
Daniel Pissaloux ◽  
Luc Durand ◽  
Franck Tirode ◽  
Bernard Guillot ◽  
...  
Keyword(s):  
Complex Rearrangement ◽  
Spitz Nevi

Evaluation of DNA ploidy in dysplastic and Spitz nevi by flow cytometry

1990 ◽  
Vol 17 (6) ◽  
pp. 342-347 ◽  
Author(s):  
Thomas S. Winokur ◽  
Juan P. Palazzo ◽  
Wayne C. Johnson ◽  
Paul H. Duray
Keyword(s):  
Flow Cytometry ◽  
Dna Ploidy ◽  
Spitz Nevi

'Tubular'structures within melanocytic proliferations: a distinctive morphologic findig not restricted to Spitz nevi

1999 ◽  
Vol 26 (6) ◽  
pp. 315-316 ◽  
Author(s):  
H Peter Soyer ◽  
Friedrich Breier ◽  
Lornzo Cerroni ◽  
Helmut Kert
Keyword(s):  
Spitz Nevi

Concurrent Loss of Heterozygosity and Mosaic Deletion of 12p13.32pter

2016 ◽  
Vol 148 (2-3) ◽  
pp. 174-178
Author(s):  
Rosana S. Faria ◽  
Claudiner P. de Oliveira ◽  
Marcella M. da Costa ◽  
Maria T.A. da S. Rosa ◽  
Mara S. Córdoba ◽  
...  
Keyword(s):  
Loss Of Heterozygosity ◽  
Microarray Analysis ◽  
Array Cgh ◽  
Distal Segment ◽  
Chromosome 12 ◽  
Chromosome Microarray Analysis ◽  
Complex Rearrangement ◽  
Snp Data ◽  
Break Induced Replication ◽  
Chromosome Microarray

Deletions in the short arm of chromosome 12 are the rarest subtelomeric imbalances. Less than 20 patients have been reported to date, and their microdeletions were identified either by FISH or array-CGH without SNP data. Here, we report a patient with a 12p13.32pter mosaic deletion detected by chromosome microarray analysis with loss of heterozygosity (LOH) of the deleted segment in addition to the adjacent distal segment. LOH is indicative of a complex rearrangement, suggestive of mitotic microhomology-mediated break-induced replication.

Complex rearrangement of chromosomes 1, 7, 21, 22 in Ewing sarcoma

2010 ◽  
Vol 201 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Natini Jinawath ◽  
Laura Morsberger ◽  
Alexis Norris-Kirby ◽  
Lisa M. Williams ◽  
Raluca Yonescu ◽  
...  
Keyword(s):  
Ewing Sarcoma ◽  
Complex Rearrangement

SPITZ NEVUS (JUVENILE MELANOMA) IN THE PEDIATRICIANS PRACTICE: CLINICAL PICTURE, DIAGNOSIS, PROGNOSIS AND TREATMENT

2021 ◽  
Vol 100 (1) ◽  
pp. 166-172
Author(s):  
O.B. Tamrazova ◽  
◽  
V.Y. Sergeev ◽  
V.G. Nikitaev ◽  
A.V. Taganov ◽  
...  
Keyword(s):  
Clinical Picture ◽  
Spindle Cell ◽  
Special Group ◽  
Pediatric Practice ◽  
Genetic Characteristics ◽  
Spitz Nevus ◽  
Histological Picture ◽  
Spitz Nevi ◽  
Risk Degree ◽  
Benign Course

Spitz nevi (epithelioid and spindle-cell nevi) are a special group of melanocytic neoplasms with a specific clinical, dermatoscopic and histological picture. There are typical and atypical Spitz nevus. The typical Spitz nevus is more common in pediatric practice and has a benign course. Of particular interest are atypical forms that combine the characteristics of a typical Spitz nevus and melanoma. The article presents an analysis of the clinical picture, dermatoscopic, immunohistochemical, histological and genetic characteristics in various forms of Spitz nevus. The existing classification according to the metastasis risk degree is presented. The last recommendations on the tactics of managing patients with this nosology are discussed with examples of original observations.

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