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Biology ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 136
Author(s):  
Satya Srirama Karthik Divvela ◽  
Darius Saberi ◽  
Beate Brand-Saberi

Atoh8 belongs to a large superfamily of transcriptional regulators called basic helix-loop-helix (bHLH) proteins. bHLH proteins have been identified in a wide range of organisms from yeast to humans. The members of this special group of transcription factors were found to be involved not only in embryonic development but also in disease initiation and its progression. Given their importance in several fundamental processes, the translation, subcellular location and turnover of bHLH proteins is tightly regulated. Alterations in the expression of bHLH proteins have been associated with multiple diseases also in context with Atoh8 which seems to unfold its functions as both transcriptional activator and repressor. Like many other bHLH transcription factors, so far, Atoh8 has also been observed to be involved in both embryonic development and carcinogenesis where it mainly acts as tumor suppressor. This review summarizes our current understanding of Atoh8 structure, function and regulation and its complex and partially controversial involvement in development and disease.


2022 ◽  
Vol 27 ◽  
pp. 83-92
Author(s):  
Lucia Csachová ◽  
Mária Jurečková

Besides providing information to pupils, their parents, teachers, and school founders about the achieved level in mathematics, the pupils’ results in mathematics at international or national testing can also be used for other purposes. In our research, the results of Slovak national testing T9 (success rate of pupils and difficulty of individual thematic areas and test items) seem to us to be a reasonable source for identification of critical areas in school mathematics. Based on the findings of such areas, we target more at these areas in the preparation of future teachers of mathematics. The special group of problems, so-called problems with figures, seems to be one of the critical areas. In the assignment of these problems, a part of the input information is not of a purely textual character, and in the process of solving the solver has to read information about objects appearing in the problem and relations between objects from figures (e. g. scheme, graph, chart, table, picture or map). The paper focuses on success rates of pupils in solving problems of this type and on various roles and functions of figures in problems with figures from the testing T9.


Author(s):  
Резида Ахметьяновна Сулейманова

Статья посвящена изучению башкирских фамилий, восходящих к древним охранительным (апотропеическим) личным именам, призванным отвратить «злые силы» от новорожденного, вышедшим из употребления и отсутствующим в современном башкирском именнике. Основным источником данного исследования послужили башкирские фамилии, зафиксированные в сборнике документов «Формулярные списки о службе чиновников Башкирско-мещерякского войска за 1836–1842 годы», вышедшем в двух книгах (2012, 2014 гг.), в которых опубликованы документы второй четверти XIX в., в первую очередь, формулярные списки чиновников Башкирско-мещерякского войска. Сравнительно-историческое исследование значений отдельных личных имен на общетюркском фоне проводилось с опорой на данные, извлеченные из «Древнетюркского словаря» и «Башкирских шэжэрэ» Р. Г. Кузеева. На основе трудов этнокультурной направленности не только в области тюркских народов, но и восточных славян, было установлено, что происхождение многих охранительных имен связано с обрядом купли-продажи ребенка, в частности, это имена на основе лексем һатыу ‘продавать’, түләү ‘платить’, табыу ‘находить’, ҡал в значении ‘(этот) не умер, остался’, торһон, в которую вложено значение йәшәһен, үлмәһен ‘пусть живет, останется’, туҡта ‘стой, остановись’. Защищенным, по мнению древних башкир, считался и тот ребенок, который, по условиям старинного обряда, пролежал в собачьей конуре рядом с ее хозяином и был наречен именем, содержащим в своей основе лексему эт ‘собака’. Защитными силами, по мнению древних башкир, обладали также и названия камней и минералов, такие как, алтын ‘золото’, көмөш ‘серебро’, булат ‘булат’ и, конечно же, тимер ‘железо’, на которое обменивали ребенка во время мнимой купли-продажи. В целях защиты от злых сил у древних башкир существовала также традиция нарекания ребенка плохим именем (к примеру, Бузук, Яманбай и т. д.). В особую группу выделяются и охранительные личные имена с компонентом иш ‘пара, чета’, которым нарекали детей, если предыдущие их братья либо сестры не выживали. Все рассмотренные нами охранительные личные имена, являющиеся отражением обряда купли-продажи младенца, а также веры народа в силу слова, в настоящее время бытуют в основном лишь в фамилиях. The article is devoted to the study of Bashkir surnames that go back to the ancient protective (apotropic) personal names, designed to ward off "evil forces" from a newborn, which are obsolete and absent in the modern Bashkir name list. The main source of this study was the Bashkir surnames recorded in the collection of documents "Formulary lists on the service of officials of the Bashkir-Meshcheryak army for 1836-1842", published in two books (2012, 2014), in which documents of the second quarter of the 19th century were published. , first of all, formular lists of officials of the Bashkir-Meshcheryak army. A comparative-historical study of the meanings of individual personal names against the general Turkic background was carried out based on data extracted from the “Ancient Turkic dictionary” and “Bashkir shezhere” by R. G. Kuzeeva. On the basis of ethnocultural works not only in the field of the Turkic peoples, but also of the Eastern Slavs, it was established that the origin of many protective names is associated with the ritual of buying and selling a child, in particular, these are names based on the lexemes katyu 'sell', tүlәү 'pay' , tabyu 'find', al in the meaning '(this) did not die, remained', tor ,on, in which the meaning of yshәһen is embedded, үlmәһen 'let him live, stay', tuҡta 'stop, stop'. Protected, according to the ancient Bashkirs, was considered the child who, according to the terms of the old rite, lay in a dog kennel next to its owner and was named with a name containing the lexeme et ‘dog’. The names of stones and minerals, such as altyn 'gold', kөmөsh 'silver', bulat 'bulat' and, of course, timer 'iron', for which the child was exchanged during the imaginary purchase and sale. In order to protect against evil forces, the ancient Bashkirs also had a tradition of criticizing a child with a bad name (for example, Buzuk, Yamanbai, etc.). Protective personal names with the ish ‘couple, couple’ component, which were given to children if their previous brothers or sisters did not survive, also stand out in a special group. All the protective personal names we have considered, which are a reflection of the ceremony of buying and selling a baby, as well as the people's belief in the power of the word, are currently mainly found in surnames.


2021 ◽  
Vol 3 (3) ◽  
pp. 78-82
Author(s):  
Gülnaz Şahin ◽  
Ferruh Acet ◽  
Ege Nazan Tavmergen Goker ◽  
Erol Tavmergen

Objective: We aimed to evaluate the obstetric and neonatal outcomes of singleton pregnancies at risk for preterm birth (PTB) following assisted reproductive treatments and underwent cervical cerclage placement. Material and methods: A total of 42 women with singleton pregnancies following ART who underwent cerclage between 2009-2021 were included in this retrospective study.  Indications of the cerclage procedure, gestational age at cerclage placement and delivery, neonatal birthweight, and requirement for admission to the neonatal unit of newborns were evaluated. Results: Of those cerclage placement performed in women with a history of second-trimester loss (19%), women with suspected cervical insufficiency according to pre-pregnancy evaluation (52.4%), women with the unicornuate uterus (4.8%), women with cervical shortening/or suspicious changes on ultrasonography (11.9%), and women with detection of cervical dilatation/shortening beyond 20 weeks of gestation (11.9%). Of the total group, 7.1% resulted in late miscarriages, while the remaining 92.9% ended with a live birth with mean gestational age at delivery of 37.0±2.5 weeks. Of those live births, 92.3% (36/39) delivered at >34 weeks and %74.4 (29/39) delivered at term. Except one neonatal death due to extremely PTB at 26th weeks, all infants were discharged from the hospital with well condition. Conclusion: ART pregnancies are evaluated as a special group as having a higher PTB risk at baseline. Cerclage may be considered in broader indications for suspected cervical insufficiency in these pregnancies. There is need for further studies on the effectiveness of cerclage in these ART pregnancies with suspected cervical insufficiency based on different criterions used.


2021 ◽  
Vol 1 ◽  
pp. 1467-1471
Author(s):  
Esti Sulistianti ◽  
Herni Rejeki

AbstractDsymenorrhea is pain in the abdomen which comes from uterine cramps and it occurs during menstruation. One of non-pharmacological therapies to overcome pain is by listening murottal surah Ar-Rahman. This study aims to apply the therapy in the order to reduce the pain in adolescent. It focused on 6 teenagers who had dysmenorrhea pain when getting menstruation. The result stated before appiying the method, they got pain in scale 7-8. Then after appiying murottal listening, this pain reduced into scale 0-3. The conclusion is by listening murottal expected for the teenagers who have this pain to listen murottal. Murottal listening therapy that is done by each member of the special group for teenagers has different declines. Suggestions for members of special groups for adolescents for patients are expected to be able to overcome pain by applying murottal listening according to what has been taught.Keywords: Dysmenorrhea; pain; therapy off murottal AbstrakDismenore merupakan nyeri pada bagian perut yang berasal dari kram rahim dan terjadi selama menstruasi. Terapi nonfarmakologi untuk mengatasi dismenore yaitu dengan mendengarkan murottal surat Ar-Rahman. Tujuan studi kasus adalah menerapkan terapi murottal untuk menurunkan nyeri dismenore pada remaja. Fokus studi kasus ini adalah menerapkan terapi murottal pada remaja yang mengalami dismenore dengan anggota kelompok 6 orang. Hasil penurunan skala nyeri yang sebelum dilakukan terapi murottal 7-8, setelah mendengarkan murottal Ar-rahman skala nyeri turun 0-3. Kesimpulannya adalah mendengarkan murottal dapat menurunkan nyeri dismenore pada anggota kelompok khusus remaja. Terapi mendengarkan murottal yang dilakukan setiap anggota kelompok khusus remaja penurunannya berbeda-beda. Saran bagi anggota kelompok khusus remaja bagi pasien diharapkan dapat mengatasi nyeri dengan penerapan mendengarkan murottal sesuai yang telah diajarkan.Kata kunci: Dismenore; nyeri; terapi murottal


2021 ◽  
Vol 7 (1) ◽  
pp. 419-427
Author(s):  
Ildikó Ernszt ◽  
Zsuzsanna Marton

Before the COVID pandemic, solo travel was getting more and more popular – especially among women travelers. Both demographic, social trends, and inner motivations enhanced the popularity of this type of travel. The aging society and the single lifestyle increased the demand on the one hand, while on the other hand, the desire for self-realization, to find new ways of life, escapism, the thirst for self-confidence drive more tourists to travel alone. In the case of women travelers, their increasing decisive power and independence also boosted solo travel. The tourism industry also offers several attractions specially designed for them. The post-pandemic era will show how this special group of travelers will react to the changed circumstances and how they will change their travel habits. The paper examines how frequently Hungarian respondents travel alone and what their attitudes towards this type of traveling are. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


2021 ◽  
Vol 1209 (1) ◽  
pp. 012050
Author(s):  
O Nespesny ◽  
J Pencik ◽  
J Vystrcil ◽  
D Beckovsky

Abstract Cement fiber boards (CFB) are special group that are used in a wide range of structural civil engineering. For the correct design of a cement fibre board structure, it is important to define their material and elastic constants, which are usually determined by destructive tests. The paper deals with a definition of a suitable method of loading for the determination of basic materials and elastic constants of cement fiber boards reinforced with organic fibers loaded in the mid-plane. The publication compares and evaluates load tests by three-point and four-point bend.


2021 ◽  
Vol 17 (3) ◽  
pp. 97-105
Author(s):  
O. I. Gushchina ◽  
N. G. Lozhkina

In a pandemic, a special group is made up of patients with cardiovascular pathology. Cardiovascular diseases are largely associated with an increase in mortality and an increased risk of complications in patients infected with the SARS-CoV-2 virus. This determines the importance of risk stratification, the choice of optimal personalized therapy and the study of the long-term prognosis of myocardial infarction against the background of infection caused by SARS-CoV-2. Despite the rapidly growing attention to this issue, the mechanisms of the relationship between cardiovascular disease and COVID-19 are not completely clear. We conducted a systematic review to summarize important aspects of COVID-19 for cardiologists. The authors discuss both well-studied factors of the infectious process leading to acute myocardial damage and decompensation of existing chronic cardiac diseases, and new, fundamental, determining prognosis and treatment. Information on the topic was used from publications based on the PubMed, Google Scholar and eLibrary.ru databases. This work was carried out within the framework of a research grant № 67573613 of Pfizer.


Author(s):  
Rail' Shamionov

The paper considers the findings of the study of discriminatory attitudes, their characteristics and factors. The author employs empirical data showing the multi-vector nature of discriminatory attitudes, their correlations, and situational tension. The paper reveals a four-component structure of discrimination signs that differ from the ones prevailing in Europe. The structure suggests a special group of signs (on the basis of social status). The author establishes a multilevel determination of discriminatory attitudes by personality traits and social ideology. The paper also includes the conclusion on the promising areas of study of discriminatory attitudes.


2021 ◽  
Vol 14 (3) ◽  
pp. 324-326
Author(s):  
Maria Łukasiewicz ◽  
Marta Swarowska-Skuza

Arterial hypertension, as a very widespread chronic disease, and thus differing in both pathomechanism and course in patients, requires a significant individualization of pharmacotherapy. One such special group is the elderly. Both the low-renin pathomechanism of arterial hypertension and its phenotype (isolated systolic hypertension) imply the choice of a specific pharmacotherapy. Additionally, in this group, side effects should be observed much more vigilantly, while target blood pressure values should be treated more liberally. An example of antihypertensive therapy in a patient belonging to the group described is presented in the following case.


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