SPITZ NEVUS (JUVENILE MELANOMA) IN THE PEDIATRICIANS PRACTICE: CLINICAL PICTURE, DIAGNOSIS, PROGNOSIS AND TREATMENT

2021 ◽  
Vol 100 (1) ◽  
pp. 166-172
Author(s):  
O.B. Tamrazova ◽  
◽  
V.Y. Sergeev ◽  
V.G. Nikitaev ◽  
A.V. Taganov ◽  
...  
Keyword(s):  
Clinical Picture ◽  
Spindle Cell ◽  
Special Group ◽  
Pediatric Practice ◽  
Genetic Characteristics ◽  
Spitz Nevus ◽  
Histological Picture ◽  
Spitz Nevi ◽  
Risk Degree ◽  
Benign Course

Spitz nevi (epithelioid and spindle-cell nevi) are a special group of melanocytic neoplasms with a specific clinical, dermatoscopic and histological picture. There are typical and atypical Spitz nevus. The typical Spitz nevus is more common in pediatric practice and has a benign course. Of particular interest are atypical forms that combine the characteristics of a typical Spitz nevus and melanoma. The article presents an analysis of the clinical picture, dermatoscopic, immunohistochemical, histological and genetic characteristics in various forms of Spitz nevus. The existing classification according to the metastasis risk degree is presented. The last recommendations on the tactics of managing patients with this nosology are discussed with examples of original observations.

scholarly journals Clinical evolution of Spitz nevi

2020 ◽  
Vol 27 (2) ◽  
pp. E2020213
Author(s):  
Marian Voloshynovych ◽  
Cliff Rosendahl ◽  
Galyna Girnyk ◽  
Ivanna Tsidylo ◽  
Iryna Blaha
Keyword(s):  
Differential Diagnosis ◽  
Rapid Growth ◽  
Research Method ◽  
Peripheral Zone ◽  
Skin Melanoma ◽  
Dynamic Changes ◽  
Spitz Nevus ◽  
Clinical Evolution ◽  
Different Types ◽  
Spitz Nevi

Nevus Spitz is a benign melanocytic proliferation, first described in 1948 by Sophie Spitz as a childhood melanoma. Initially, it was described as an erythematous papule or node, but further studies of the Spitz nevus proved that in 71-92% cases it is a pigmented formation. This pigmentation is often quite intense due to the rapid growth of the formation, which leads to the need for differential diagnosis with skin melanoma. After all, dermatoscopy can be used for this purpose and, when applying this research method, typically a pattern of an exploding star formed by streaks of linear pigmentation and symmetrically located pigment globules placed in the peripheral zone can be revealed. In case of non-pigmented Spitz nevus, spot vessels and reticular depigmentation are visualized. Both pigmented and non-pigmented forms of Spitz nevus in the process of evolution can regress partially or completely. Several clinical cases of different types of spitzoids, both typical and atypical, based on the non-clinical, dermatoscopic and histological diversity of the Spitz nevi, have been demonstrated in the article. Their macroscopic and dermatoscopic features as well as probable signs of dynamic changes are indicated in order to facilitate their recognition by other specialists.

Pediatrics: nominal symptoms and syndromes

2019 ◽  
Author(s):  
Лариса Балыкова ◽  
Larisa Balykova ◽  
Дмитрий Печкуров ◽  
Dmitriy Pechkurov ◽  
Екатерина Акашкина ◽  
...  
Keyword(s):  
Medical School ◽  
Clinical Picture ◽  
Evidence Based Medicine ◽  
Evidence Based ◽  
Pediatric Practice ◽  
Alphabetical Order ◽  
Treatment And Prevention ◽  
Pediatric Diseases ◽  
Based Medicine ◽  
Symptoms And Signs

The guide will allow pediatricians to get information about the meaning of eponymous terms that they face in practice, educational and scientific activities, it contains 1212 eponymous symptoms, samples and reflexes, 752 symptom complexes, syndromes and diseases relevant to pediatric practice. The book consists of two parts, the first part includes the semiotics of pediatric diseases and presents their symptoms and signs. In the second part of the guide are syndromes and nosological units, which are systematized in alphabetical order. Their interpretation, historical information, data on epidemiology, etiology, pathogenesis and clinical picture of nosological units are given. From the standpoint of evidence-based medicine provides information on the diagnosis, treatment and prevention of these conditions, which may occur in the practice of a pediatrician. The guide is addressed to pediatricians, it is useful to researchers, teachers of higher medical school.

scholarly journals Spitz nevus and Reed nevus

2012 ◽  
Vol 87 (3) ◽  
pp. 349-359 ◽  
Author(s):  
Alessandra Yoradjian ◽  
Mílvia Maria Simões e Silva Enokihara ◽  
Francisco Macedo Paschoal
Keyword(s):  
Natural History ◽  
Diagnostic Tool ◽  
Epithelioid Cell ◽  
Special Group ◽  
Spitz Nevus ◽  
Histopathological Features ◽  
Melanocytic Lesions ◽  
Molecular Studies

Spitz and Reed nevi, also called spindle and/or epithelioid cell nevi, are a special group of melanocytic lesions due to their peculiar clinical, dermoscopic and histopathological features. The study of these nevi is of great interest because both their nomenclature and classification are still a matter of discussion. Most importantly, the difficulty to differentiate them from melanoma can lead to inadequate therapies. In this context, dermoscopy, a link between clinical and anatomopathological examinations, appears as a helpful diagnostic tool whose accuracy can reach 93%. "Borderline" lesions are still a great challenge and object of research, including molecular studies. The present study explores the relevant characteristics of these nevi, with emphasis on dermoscopic findings, aiming at understanding their natural history, as well as discussing treatment and patient follow-up.

Solitary Spindle Cell Xanthogranuloma Mimicking a Spitz Nevus

2013 ◽  
Vol 35 (8) ◽  
pp. 865-867 ◽  
Author(s):  
Yoshitaka Nakamura ◽  
Akiko Nakamura ◽  
Masahiko Muto
Keyword(s):  
Spindle Cell ◽  
Spitz Nevus

A Case of Combined Nevus: Compound Nevus and Spindle Cell Spitz Nevus

2000 ◽  
Vol 27 (4) ◽  
pp. 233-237 ◽  
Author(s):  
Zhao-hui Jin ◽  
Masanobu Kumakiri ◽  
Hisaya Ishida ◽  
Shoichi Kinebuchi
Keyword(s):  
Spindle Cell ◽  
Spitz Nevus

Clinical Review of 247 Case Records of Spitz Nevus (Epithelioid Cell and/or Spindle Cell Nevus)

Dermatology ◽  
1997 ◽  
Vol 194 (1) ◽  
pp. 20-25 ◽  
Author(s):  
V. Dal Pozzo ◽  
C. Benelli ◽  
L. Restano ◽  
R. Gianotti ◽  
B.M. Cesana
Keyword(s):  
Clinical Review ◽  
Spindle Cell ◽  
Epithelioid Cell ◽  
Spitz Nevus

EOSINOPHILIC ESOPHAGITIS IN PEDIATRIC PRACTICE

2021 ◽  
Vol 100 (6) ◽  
pp. 181-186
Author(s):  
S.G. Makarova ◽  
◽  
M.M. Lokhmatov ◽  
A.U. Bekmambetova ◽  
N.N. Murashkin ◽  
...  
Keyword(s):  
Medical Research ◽  
Eosinophilic Esophagitis ◽  
Clinical Picture ◽  
Morphological Study ◽  
Clinical Signs ◽  
Final Diagnosis ◽  
Newly Diagnosed ◽  
Pediatric Practice ◽  
Morphological Examination ◽  
National Medical

Eosinophilic esophagitis (EoE) is a disease with a nonspecific clinical picture, and characteristic changes in the mucous membrane of the esophagus often become an endoscopic finding. The final diagnosis is possible only on the basis of the results of the morphological examination. The article presents the results of examination and treatment of two patients hospitalized in the dermatological and gastroenterological departments of the National Medical Research Center of Children's Health with newly diagnosed EoE. In both cases, there were no typical clinical signs of EoE in patients, however, taking into account a number of characteristic endoscopic signs, a morphological study was carried out, the diagnosis of EoE was verified and pathogenetic treatment was prescribed with the achievement of clinical and laboratory remission.

Spindle Cell and Epithelioid Cell Nevi with Atypia and Metastasis (Malignant Spitz Nevus)

1989 ◽  
Vol 13 (11) ◽  
pp. 931-939 ◽  
Author(s):  
Kathleen J. Smith ◽  
Terry L. Barrett ◽  
Henry G. Skelton ◽  
George P. Lupton ◽  
James H. Graham
Keyword(s):  
Spindle Cell ◽  
Epithelioid Cell ◽  
Spitz Nevus
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