Multifocal ulcerations in extreme prematurity

2021 ◽  
Author(s):  
Jason G. Weed ◽  
Nooshin K. Brinster ◽  
Vikash S. Oza ◽  
Seth J. Orlow
Keyword(s):  

2021 ◽  
Vol 33 ◽  
pp. 101394
Author(s):  
Celia S. Sobelman ◽  
Stacey L. Valentine ◽  
Ted Kremer


2017 ◽  
Vol 17 (8) ◽  
pp. 34-35
Author(s):  
Kristina Orfali
Keyword(s):  


2010 ◽  
Vol 117 (2-3) ◽  
pp. 436-437
Author(s):  
Nadia Vilahur ◽  
Matthew P.G. Allen ◽  
Muriel Walshe ◽  
Chiara Nosarti ◽  
Larry Rifkin ◽  
...  


2019 ◽  
Vol 97 (3) ◽  
pp. 197-205 ◽  
Author(s):  
Mark A. Underwood ◽  
Stephen Wedgwood ◽  
Satyan Lakshminrusimha ◽  
Robin H. Steinhorn

In the premature infant, poor growth in utero (fetal growth restriction) and in the first weeks of life (postnatal growth restriction) are associated with increased risk for bronchopulmonary dysplasia and pulmonary hypertension. In this review, we summarize the epidemiologic data supporting these associations, present a novel rodent model of postnatal growth restriction, and review 5 promising mechanisms by which poor nutrition may affect the developing lung. These observations support the hypothesis that nutritional and (or) pharmacologic interventions early in life may be able to decrease risk of the pulmonary complications of extreme prematurity.





2008 ◽  
Vol 32 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Lex W. Doyle


2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Emily A. Partridge ◽  
Marcus G. Davey ◽  
Matthew A. Hornick ◽  
Patrick E. McGovern ◽  
Ali Y. Mejaddam ◽  
...  

Abstract In the developed world, extreme prematurity is the leading cause of neonatal mortality and morbidity due to a combination of organ immaturity and iatrogenic injury. Until now, efforts to extend gestation using extracorporeal systems have achieved limited success. Here we report the development of a system that incorporates a pumpless oxygenator circuit connected to the fetus of a lamb via an umbilical cord interface that is maintained within a closed ‘amniotic fluid’ circuit that closely reproduces the environment of the womb. We show that fetal lambs that are developmentally equivalent to the extreme premature human infant can be physiologically supported in this extra-uterine device for up to 4 weeks. Lambs on support maintain stable haemodynamics, have normal blood gas and oxygenation parameters and maintain patency of the fetal circulation. With appropriate nutritional support, lambs on the system demonstrate normal somatic growth, lung maturation and brain growth and myelination.





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