Beneficial effects of Strongyloides venezuelensis antigen extract in acute experimental toxoplasmosis

2020 ◽  
Author(s):  
Ester Cristina Borges Araujo ◽  
Yusmaris Cariaco ◽  
Marcos Paulo Oliveira Almeida ◽  
Marisol Patricia Pallete Briceño ◽  
José Eduardo Neto de Sousa ◽  
...  
Keyword(s):  
Beneficial Effects ◽  
Strongyloides Venezuelensis

Author response for "Beneficial effects of Strongyloides venezuelensis antigen extract in acute experimental toxoplasmosis"

2020 ◽  
Author(s):  
Ester Cristina Borges Araujo ◽  
Yusmaris Cariaco ◽  
Marcos Paulo Oliveira Almeida ◽  
Marisol Patricia Pallete Briceño ◽  
José Eduardo Neto Sousa ◽  
...  
Keyword(s):  
Author Response ◽  
Beneficial Effects ◽  
Strongyloides Venezuelensis

scholarly journals EFFECT OF Bifidobacterium animalis ON MICE INFECTED WITH Strongyloides venezuelensis

2014 ◽  
Vol 56 (2) ◽  
pp. 105-109 ◽  
Author(s):  
Teresa Cristina Goulart Oliveira-Sequeira ◽  
Érica Boarato David ◽  
Cláudia Ribeiro ◽  
Semíramis Guimarães ◽  
Ana Paula Batista Masseno ◽  
...  
Keyword(s):  
Egg Production ◽  
Parasite Burden ◽  
Control Group ◽  
Intestinal Damage ◽  
Beneficial Effects ◽  
Bifidobacterium Animalis ◽  
Nematode Larvae ◽  
Strongyloides Venezuelensis ◽  
Induce Resistance ◽  
Villous Height

The administration of viable Bifidobacterium animaliswas tested to induce resistance against Strongyloides venezuelensis infection in mice. Effects on parasite burden, worm length, egg output, and intestinal mucosal histology were evaluated. The oral administration of B. animalis, strain 04450B, starting 14 days before the inoculation of nematode larvae significantly decreased the worm burden and egg output. In probiotic treated animals, the percent reduction of adult worms in the intestine was of 33% and the reduction of egg production was of 21%, compared with those of the control group. The duodenum villous height and villous/crypt ratio were significantly higher in probiotic-treated mice, indicating that this group could be experiencing less intestinal damage. The present findings revealed that the administration of B. animalis for the amelioration of host response to nematode infections is biologically plausible and could have some potential for impacting public health. Meanwhile, further study is needed to delineate the nature and identity of the factor(s) involved in these beneficial effects.

Author response for "Beneficial effects of Strongyloides venezuelensis antigen extract in acute experimental toxoplasmosis"

2020 ◽  
Author(s):  
Ester Cristina Borges Araujo ◽  
Yusmaris Cariaco ◽  
Marcos Paulo Oliveira Almeida ◽  
Marisol Patricia Pallete Briceño ◽  
José Eduardo Neto Sousa ◽  
...  
Keyword(s):  
Author Response ◽  
Beneficial Effects ◽  
Strongyloides Venezuelensis

Nuclear receptors in disease: the oestrogen receptors

2004 ◽  
Vol 40 ◽  
pp. 157-167 ◽  
Author(s):  
Maria Nilsson ◽  
Karin Dahlman-Wright ◽  
Jan-Åke Gustafsson
Keyword(s):  
Nuclear Receptors ◽  
Target Genes ◽  
Receptor Subtype ◽  
Target Tissue ◽  
Oestrogen Receptors ◽  
Nucleotide Polymorphisms ◽  
Cell Type ◽  
Single Nucleotide ◽  
Beneficial Effects ◽  
The Family

For several decades, it has been known that oestrogens are essential for human health. The discovery that there are two oestrogen receptors (ERs), ERalpha and ERbeta, has facilitated our understanding of how the hormone exerts its physiological effects. The ERs belong to the family of ligand-activated nuclear receptors, which act by modulating the expression of target genes. Studies of ER-knockout (ERKO) mice have been instrumental in defining the relevance of a given receptor subtype in a certain tissue. Phenotypes displayed by ERKO mice suggest diseases in which dysfunctional ERs might be involved in aetiology and pathology. Association between single-nucleotide polymorphisms (SNPs) in ER genes and disease have been demonstrated in several cases. Selective ER modulators (SERMs), which are selective with regard to their effects in a certain cell type, already exist. Since oestrogen has effects in many tissues, the goal with a SERM is to provide beneficial effects in one target tissue while avoiding side effects in others. Refined SERMs will, in the future, provide improved therapeutic strategies for existing and novel indications.

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