DIAGNOSTIC ACCURACY OF TWO NUCLEIC ACID AMPLIFICATION TESTS FOR RAPID DIAGNOSIS OF TUBERCULOUS PLEURAL EFFUSION

Respirology ◽  
2017 ◽  
Vol 22 ◽  
pp. 32-33



PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243765
Author(s):  
Yanqin Shen ◽  
Likui Fang ◽  
Bo Ye ◽  
Guocan Yu

Background Abdominal tuberculosis is a severe extrapulmonary tuberculosis, which can lead to serious complications. Early diagnosis and treatment are very important for the prognosis and the diagnosis of abdominal tuberculosis is still difficult. This study aims to evaluate the diagnostic accuracy of nucleic acid amplification tests (NAATs) for abdominal tuberculosis using meta-analysis method. Methods We will search PubMed, the Cochrane Library, Embase, China National Knowledge Infrastructure, and the Wanfang database for studies evaluating the diagnostic accuracy of NAATs for abdominal tuberculosis until May 2020. We will include a systematic review and meta-analysis that evaluated the accuracy of NAATs for abdominal tuberculosis. Any types of study design with full text will be sought and included. The risk of bias will be assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. Stata version 15.0 with the midas command packages will be used to carry out meta-analyses. Results The results will provide clinical evidence for diagnostic accuracy of NAATs for abdominal tuberculosis, and this systematic review and meta-analysis will be submitted to a peer-reviewed journal for publication. Conclusion This overview will provide evidence of NAATs for diagnosis of abdominal tuberculosis. Systematic review registration INPLASY202060030.



PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250470
Author(s):  
Guocan Yu ◽  
Yanqin Shen ◽  
Xudong Xu ◽  
Lihua Lin

Background Nontuberculous mycobacteria (NTM) infection is similar to Mycobacterium tuberculosis (MTB) infection. Early clinical identification and differentiation of NTM and MTB infections continues to be a major challenge. Nucleic acid amplification tests (NAATs) have the ability to efficiently and rapidly detect pathogens and are widely used in mycobacterial infections. The objective of this study is to estimate the diagnostic accuracy of NAATs for NTM. Methods We will search candidate studies that assessing the accuracy of NAATs for diagnosis of NTM through PubMed, Embase and the Cochrane Library until May 2021. Studies with full text that meet the inclusion criteria will be included. Following a revised tool for Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2), two researchers will independently evaluate the study quality. The STATA software (version 15.0) will be used to carry out meta-analyses. When heterogeneity is observed, subgroup analyses and meta-regression analyses will be used to explore sources of heterogeneity. Sensitivity analyses will be used to check the robustness of analyses. Conclusion We hope that this study will provide meaningful evidence for the early and rapid diagnosis of NAATs for NTM, which will help to guide the treatment of NTM and improve the prognosis of patients.



2003 ◽  
Vol 3 (10) ◽  
pp. 633-643 ◽  
Author(s):  
Madhukar Pai ◽  
Laura L Flores ◽  
Nitika Pai ◽  
Alan Hubbard ◽  
Lee W Riley ◽  
...  


2014 ◽  
Vol 69 (1) ◽  
pp. 99-101 ◽  
Author(s):  
Sunil Sethi ◽  
Jaspreet Kaur ◽  
Rakesh Yadav ◽  
Sunil Kumar Dhatwalia ◽  
Abhishek Mewara ◽  
...  


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