scholarly journals P9‐50: Effect of TRPV2 rs7217735 polymorphism in the development of hypoosmotic airway hyperresponsiveness in asthma patients

Respirology ◽  
2021 ◽  
Vol 26 (S3) ◽  
pp. 382-382
Keyword(s):  
Airway Hyperresponsiveness ◽  
Asthma Patients

Dynamics of blood and sputum eosinophils in asthma patients with cold airway hyperresponsiveness during cold air provocation

2019 ◽  
Author(s):  
Juliy M. Perelman ◽  
Aleksey B. Pirogov ◽  
Anna G. Prikhodko ◽  
Elena V. Ushakova ◽  
Victor P. Kolosov
Keyword(s):  
Airway Hyperresponsiveness ◽  
Cold Air ◽  
Asthma Patients ◽  
Sputum Eosinophils

Efficiency of extrafine beclometasone dipropionat/formoterol fumarate in asthma patients with cold and/or osmotic airway hyperresponsiveness (AHR)

2019 ◽  
Author(s):  
Juliy M. Perelman ◽  
Anna G. Prikhodko ◽  
Ekaterina Y. Kochegarova ◽  
Larisa Y. Oshur ◽  
Evgeniya Y. Afanaseva
Keyword(s):  
Airway Hyperresponsiveness ◽  
Asthma Patients ◽  
Formoterol Fumarate

scholarly journals Comparative characteristics of the quality of life of asthma patients with different types of airway hyperresponsiveness to physical stimules

2021 ◽  
pp. 55-61
Author(s):  
N. L. Perelman
Keyword(s):  
Quality Of Life ◽  
Airway Hyperresponsiveness ◽  
Group 4 ◽  
Sf 36 ◽  
Different Types ◽  
Asthma Patients ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim. To compare the nature and degree of influence of different types of airway hyperresponsiveness (AHR) on the general and specific quality of life (QoL) of patients with asthma and control over the disease.Materials and methods. 234 patients with mild-to-moderate asthma, aged from 18 to 60 years old, were interviewed and examined. Depending on the presence of one or another type of AHR, 4 groups were formed: group 1 included 60 patients with cold AHR, group 2 – 75 patients with hypoosmotic AHR, group 3 – 35 patients with hyperosmotic AHR, group 4 – 64 patients with exercise-induced bronchoconstriction (EIB). QoL and the state of the emotional sphere were assessed using the SF-36, AQLQ, HADS questionnaires. The level of asthma control was determined using the ACT questionnaire. Lung function was assessed by spirometry.Results. When comparing QoL between groups, statistical differences were obtained for most of the SF-36 scales, with the exception of the domains “Role Physical” (RP) and “Bodily Pain” (BP), and their presence and significance varied depending on the types of AHR being compared. The lowest QoL indices were found in group 1 of patients with cold AHR according to the domains “Physical Activity” (PA), RP, BP, and “Role Emotional” (RE). The lowest indices for the domains “General Health” (GH), “Vitality” (V) and “Mental health” (MH) were found in the respondents of the 2nd group. Most of the highest QoL indicators in the compared groups were found in patients of group 4 with EIB in the domains PA, RP, V, RE, and MH. When carrying out a comparative analysis, the maximum number of significant differences was found between the groups with cold AHR and EIB. A comparative study of QoL using a special AQLQ questionnaire showed the lowest indices for the “Activity” and “Symptoms” domains in groups 1 and 2 of asthma patients. In addition, in group 1, the minimum QoL values were recorded for the “General QoL” domain (3.6±0.2 points), and in group 2, for the “Environment” domain (2.9±0.3 compared with 3.9±0.2 points in group 3, p<0.01).Conclusion. This study has demonstrated the multifaceted effect of AHR on health-related QoL, dependent on sensitivity to a particular physical stimulus and the season of maximum trigger action. The subjective assessment of psychosocial functioning is most differentiated according to the GH domain of the SF-36 questionnaire. The greatest negative impact on the QoL indices is exerted by the cold and hypoosmotic AHR, the least – by the EIB. The assessment of QoL allows to get a full picture of the perception of the patient's health level at the moment and in the given conditions.

scholarly journals Ruxolitinib Ameliorates Airway Hyperresponsiveness and Lung Inflammation in a Corticosteroid-Resistant Murine Model of Severe Asthma

2021 ◽  
Vol 12 ◽  
Author(s):  
Hariharan Subramanian ◽  
Tanwir Hashem ◽  
Devika Bahal ◽  
Ananth K. Kammala ◽  
Kanedra Thaxton ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Murine Model ◽  
Airway Hyperresponsiveness ◽  
Lung Inflammation ◽  
Janus Kinase ◽  
Asthma Prevalence ◽  
Asthma Patients ◽  
Antibody Titers ◽  
Model Treatment

Asthma prevalence has increased considerably over the decades and it is now considered as one of the most common chronic disorders in the world. While the current anti-asthmatic therapies are effective for most asthma patients, there are 5-10% subjects whose disease is not controlled by such agents and they account for about 50% of the asthma-associated healthcare costs. Such patients develop severe asthma (SA), a condition characterized by a dominant Th1/Th17 cytokine response that is accompanied by Type 2 (T2)-low endotype. As JAK (Janus Kinase) signaling is very important for the activation of several cytokine pathways, we examined whether inhibition of JAKs might lessen the clinical and laboratory manifestations of SA. To that end, we employed a recently described murine model that recapitulates the complex immune response identified in the airways of human SA patients. To induce SA, mice were sensitized with house dust mite extract (HDME) and cyclic (c)-di-GMP and then subsequently challenged with HDME and a lower dose of c-di-GMP. In this model, treatment with the JAK inhibitor, Ruxolitinib, significantly ameliorated all the features of SA, including airway hyperresponsiveness and lung inflammation as well as total IgE antibody titers. Thus, these studies highlight JAKs as critical targets for mitigating the hyper-inflammation that occurs in SA and provide the framework for their incorporation into future clinical trials for patients that have severe or difficult-to manage asthma.

scholarly journals Seasonal dynamics of cold airway hyperresponsiveness in patients with asthma

2021 ◽  
pp. 45-54
Author(s):  
A. G. Prikhodko ◽  
J. M. Perelman
Keyword(s):  
Asthma Control ◽  
Seasonal Dynamics ◽  
Airway Hyperresponsiveness ◽  
Clinical Symptoms ◽  
Mean Value ◽  
Life Assessment ◽  
Asthma Control Test ◽  
Mean Values ◽  
Asthma Patients ◽  
Airway Response

Introduction. Cold air-induced bronchoconstriction in patients with asthma, leading to a breakdown in disease control, is one of the most serious problems in the northern countries of the world.Aim. To assess the seasonal dynamics of the airway response (ΔFEV1CA) to cold bronchoprovocation in asthma patients with cold airway hyperresponsiveness (CAHR).Materials and methods. Out of 513 asthma patients who underwent primary bronchoprovocation testing, 273 patients (140 women; 133 men) with diagnosed CAHR took part in the retrospective analysis. The design objectification of clinical data using the Asthma Control Test questionnaire (ACT, Quality Metric Inc., 2002), a screening questionnaire for identifying clinical symptoms of response to low ambient temperature in everyday life; assessment of the lung function; bronchoprovocation test of 3-minute isocapnic hyperventilation with cold (-20ºC) air (IHCA).Results. At the time of testing, the average age of patients was 34.8±0.87 years, FEV1 88.5±1.3% of predicted, FEV1/VC 70.9±0.7%; ACT 16 (12; 19) points. On average in the group, ΔFEV1CA was -19.2±0.6%. The frequency of CAHR detection in the winter was 22%, spring – 34%, summer – 22%, autumn – 24% (p>0.05). The minimum changes in FEV1 in response to IHCA were recorded in May-June (mean value ΔFEV1CA -16.2±1.3 and -14.5±1.6%, respectively) and were significantly less in comparison with February (-21.9±2.3%, p˂0.05) and April (-23.0±2.36%, p˂0.01). A correlation has been found between the monthly mean values of meteorological parameters and CAHR, as well as the value of ACT in points and ΔFEV1 (r=0.16; p=0.018).Conclusion. Seasonal changes in the strength of the action of meteorological factors produce a change in the response of the airways to cold bronchoprovocation, and contribute to the loss of asthma control. The maximum values of CAHR fall on February-April, August, November. The data obtained reflect the presence of a complex  interaction of physical environmental factors in the induction of seasonal fluctuations of CAHR, which requires a search for specific mechanisms for the formation of altered airway reactivity associated with the characteristics of molecular reception of low temperatures and humidity in the human airways.

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