Timeliness of vesicular disease notification system in Brazilian foot‐and‐mouth disease surveillance programme

2020 ◽  
Vol 67 (4) ◽  
pp. 1517-1531
Author(s):  
Edyniesky Ferrer‐Miranda ◽  
Erivânia Camelo Almeida ◽  
Cláudio Tadeu Cristino ◽  
Jones Albuquerque ◽  
Kleber Régis Santoro
Keyword(s):  
Disease Surveillance ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Disease Notification ◽  
Surveillance Programme ◽  
Notification System ◽  
Foot And Mouth ◽  
Vesicular Disease

scholarly journals Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus

Pathogens ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 729
Author(s):  
Bo Yang ◽  
Xiaohui Zhang ◽  
Dajun Zhang ◽  
Jing Hou ◽  
GuoWei Xu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Disease Virus ◽  
Molecular Mechanisms ◽  
Immune Escape ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Host Immune Responses ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Vesicular Disease

Foot-and-mouth disease virus (FMDV) causes a highly contagious vesicular disease in cloven-hoofed livestock that results in severe consequences for international trade, posing a great economic threat to agriculture. The FMDV infection antagonizes the host immune responses via different signaling pathways to achieve immune escape. Strategies to escape the cell immune system are key to effective infection and pathogenesis. This review is focused on summarizing the recent advances to understand how the proteins encoded by FMDV antagonize the host innate and adaptive immune responses.

Differentiation of a vesicular disease of pigs in Hong Kong from foot-and-mouth disease

1972 ◽  
Vol 90 (22) ◽  
pp. 618-621 ◽  
Author(s):  
G. Mowat ◽  
J. Darbyshire ◽  
J. Huntley
Keyword(s):  
Hong Kong ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth ◽  
Vesicular Disease

scholarly journals The airborne excretion by pigs of swine vesicular disease virus

1974 ◽  
Vol 72 (1) ◽  
pp. 61-65 ◽  
Author(s):  
R. F. Sellers ◽  
K. A. J. Herniman
Keyword(s):  
Respiratory Tract ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Swine Vesicular Disease Virus ◽  
Foot And Mouth ◽  
Vesicular Disease

SUMMARYThe air of loose-boxes holding pigs affected with swine vesicular disease was sampled for virus. In the multistage impinger virus to a titre of 102·6TCID50 was associated with particles greater than 6 μm., 101·6with particles 3–6 μm. and 101·4or less with particles less than 3 μm. In the noses of workers in contact with the pigs for periods not less than 5 min., virus to a titre of 102·4TCID50 was found. Virus was recovered from the air for 2–3 days during the disease and maximum titre in pigs infected by injection or by contact occurred on the second to third day after generalization of the lesions. The amounts of virus were about 160-fold less than those recovered from pigs affected with foot-and-mouth disease, and the quantity and time of excretion suggest that the source of swine vesicular disease virus in the aerosol may be from the lesions and skin rather than from the respiratory tract.

High seroprevalence of Foot and Mouth Disease in Laos: Call for nationwide vaccination campaigns and disease surveillance

2020 ◽  
Author(s):  
Kinnaly Xaydalasouk ◽  
Nouna Innoula ◽  
Vannaphone Putthana ◽  
Korakan Chanthavongsa ◽  
Chantal J. Snoeck ◽  
...  
Keyword(s):  
Disease Surveillance ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
High Seroprevalence ◽  
Foot And Mouth ◽  
Vaccination Campaigns

scholarly journals Inter-laboratory comparison of 2 ELISA kits used for foot-and-mouth disease virus nonstructural protein serology

2020 ◽  
Vol 32 (6) ◽  
pp. 933-937
Author(s):  
Clare F. J. Browning ◽  
Antonello Di Nardo ◽  
Lissie Henry ◽  
Tim Pollard ◽  
Lynne Hendry ◽  
...  
Keyword(s):  
Disease Virus ◽  
Disease Surveillance ◽  
Nonstructural Protein ◽  
Foot And Mouth Disease ◽  
Screen Test ◽  
Mouth Disease ◽  
Nonstructural Proteins ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Thermo Fisher Scientific

Serologic assays used to detect antibodies to nonstructural proteins (NSPs) of foot-and-mouth disease virus (FMDV) are used for disease surveillance in endemic countries, and are essential to providing evidence for freedom of the disease with or without vaccination and to recover the free status of a country after an outbreak. In a 5-site inter-laboratory study, we compared the performance of 2 commercial NSP ELISA kits (ID Screen FMD NSP ELISA single day [short] and overnight protocols, ID.Vet; PrioCHECK FMDV NS antibody ELISA, Thermo Fisher Scientific). The overall concordance between the PrioCHECK and ID Screen test was 93.8% (95% CI: 92.0–95.2%) and 94.8% (95% CI: 93.1–96.1%) for the overnight and short ID Screen incubation protocols, respectively. Our results indicate that the assays (including the 2 different formats of the ID Screen test) can be used interchangeably in post-outbreak serosurveillance.

scholarly journals Dynamics of picornavirus RNA replication within infected cells

2008 ◽  
Vol 89 (2) ◽  
pp. 485-493 ◽  
Author(s):  
Graham J. Belsham ◽  
Preben Normann
Keyword(s):  
Disease Virus ◽  
Rna Synthesis ◽  
Foot And Mouth Disease ◽  
Rna Replication ◽  
Mouth Disease ◽  
Swine Vesicular Disease Virus ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Infected Cells ◽  
Vesicular Disease

Replication of many picornaviruses is inhibited by low concentrations of guanidine. Guanidine-resistant mutants are readily isolated and the mutations map to the coding region for the 2C protein. Using in vitro replication assays it has been determined previously that guanidine blocks the initiation of negative-strand synthesis. We have now examined the dynamics of RNA replication, measured by quantitative RT-PCR, within cells infected with either swine vesicular disease virus (an enterovirus) or foot-and-mouth disease virus as regulated by the presence or absence of guanidine. Following the removal of guanidine from the infected cells, RNA replication occurs after a significant lag phase. This restoration of RNA synthesis requires de novo protein synthesis. Viral RNA can be maintained for at least 72 h within cells in the absence of apparent replication but guanidine-resistant virus can become predominant. Amino acid substitutions within the 2C protein that confer guanidine resistance to swine vesicular disease virus and foot-and-mouth disease virus have been identified. Even when RNA synthesis is well established, the addition of guanidine has a major impact on the level of RNA replication. Thus, the guanidine-sensitive step in RNA synthesis is important throughout the virus life cycle in cells.

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