Decision letter for "ESCRT-dependent protein sorting is required for the viability of yeast clathrin-mediated endocytosis mutants"

2020 ◽  
Keyword(s):  
Protein Sorting ◽  
Dependent Protein

scholarly journals Ceramide chain length–dependent protein sorting into selective endoplasmic reticulum exit sites

2020 ◽  
Vol 6 (50) ◽  
pp. eaba8237
Author(s):  
Sofia Rodriguez-Gallardo ◽  
Kazuo Kurokawa ◽  
Susana Sabido-Bozo ◽  
Alejandro Cortes-Gomez ◽  
Atsuko Ikeda ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Chain Length ◽  
Secretory Pathway ◽  
Protein Sorting ◽  
Endoplasmic Reticulum Membrane ◽  
Lipid Chain ◽  
Secretory Transport ◽  
Dependent Protein ◽  
Cellular Compartmentalization

Protein sorting in the secretory pathway is crucial to maintain cellular compartmentalization and homeostasis. In addition to coat-mediated sorting, the role of lipids in driving protein sorting during secretory transport is a longstanding fundamental question that still remains unanswered. Here, we conduct 3D simultaneous multicolor high-resolution live imaging to demonstrate in vivo that newly synthesized glycosylphosphatidylinositol-anchored proteins having a very long chain ceramide lipid moiety are clustered and sorted into specialized endoplasmic reticulum exit sites that are distinct from those used by transmembrane proteins. Furthermore, we show that the chain length of ceramide in the endoplasmic reticulum membrane is critical for this sorting selectivity. Our study provides the first direct in vivo evidence for lipid chain length–based protein cargo sorting into selective export sites of the secretory pathway.

γ2 and γ1AP-1 complexes: Different essential functions and regulatory mechanisms in clathrin-dependent protein sorting

2017 ◽  
Vol 96 (4) ◽  
pp. 356-368 ◽  
Author(s):  
Daniela Zizioli ◽  
Constanze Geumann ◽  
Manuel Kratzke ◽  
Ratnakar Mishra ◽  
Guiseppe Borsani ◽  
...  
Keyword(s):  
Protein Sorting ◽  
Regulatory Mechanisms ◽  
Dependent Protein

Author response for "ESCRT-dependent protein sorting is required for the viability of yeast clathrin-mediated endocytosis mutants"

2020 ◽  
Author(s):  
Kyle Hoban ◽  
Samantha Y. Lux ◽  
Joanna Poprawski ◽  
Yorke Zhang ◽  
James Shepherdson ◽  
...  
Keyword(s):  
Protein Sorting ◽  
Author Response ◽  
Dependent Protein

scholarly journals Palmitoylation-dependent protein sorting

2007 ◽  
Vol 176 (3) ◽  
pp. 249-254 ◽  
Author(s):  
Jennifer Greaves ◽  
Luke H. Chamberlain
Keyword(s):  
Membrane Protein ◽  
Protein Interactions ◽  
Posttranslational Modification ◽  
Protein Sorting ◽  
Transmembrane Proteins ◽  
Compelling Evidence ◽  
Hydrophobic Membrane ◽  
Membrane Anchor ◽  
Different Types ◽  
Dependent Protein

S-palmitoylation is a posttranslational modification that regulates membrane–protein interactions. However, palmitate is more than just a hydrophobic membrane anchor, as many different types of protein are palmitoylated, including transmembrane proteins. Indeed, there is now compelling evidence that palmitoylation plays a key role in regulating various aspects of protein sorting within the cell.

scholarly journals An investigation of the effect of membrane curvature on transmembrane-domain dependent protein sorting in lipid bilayers

2014 ◽  
Vol 4 (2) ◽  
pp. e29087 ◽  
Author(s):  
Matteo Fossati ◽  
Bruno Goud ◽  
Nica Borgese ◽  
Jean-Baptiste Manneville
Keyword(s):  
Lipid Bilayers ◽  
Transmembrane Domain ◽  
Protein Sorting ◽  
Membrane Curvature ◽  
Dependent Protein
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