Follow‐up program for blood donors with unconfirmed screening results reveals a high false‐positive rate in Dalian, China

Transfusion ◽  
2020 ◽  
Vol 60 (2) ◽  
pp. 334-342
Author(s):  
Xuelian Deng ◽  
Liang Zang ◽  
Xinmei Wang ◽  
Hui Chen ◽  
Jiangdi Liu ◽  
...  
Keyword(s):  
False Positive ◽  
Blood Donors ◽  
False Positive Rate ◽  
High False Positive Rate ◽  
Positive Rate

Improving diagnosis of acute appendicitis with atypical findings by Tc-99m HMPAO leukocyte scan

2002 ◽  
Vol 41 (01) ◽  
pp. 37-41 ◽  
Author(s):  
S. Shung-Shung ◽  
S. Yu-Chien ◽  
Y. Mei-Due ◽  
W. Hwei-Chung ◽  
A. Kao
Keyword(s):  
Acute Appendicitis ◽  
False Positive ◽  
False Positive Rate ◽  
Accurate Method ◽  
Clinical Findings ◽  
Pathological Findings ◽  
Lower Quadrant ◽  
Predictive Values ◽  
Positive Rate

Summary Aim: Even with careful observation, the overall false-positive rate of laparotomy remains 10-15% when acute appendicitis was suspected. Therefore, the clinical efficacy of Tc-99m HMPAO labeled leukocyte (TC-WBC) scan for the diagnosis of acute appendicitis in patients presenting with atypical clinical findings is assessed. Patients and Methods: Eighty patients presenting with acute abdominal pain and possible acute appendicitis but atypical findings were included in this study. After intravenous injection of TC-WBC, serial anterior abdominal/pelvic images at 30, 60, 120 and 240 min with 800k counts were obtained with a gamma camera. Any abnormal localization of radioactivity in the right lower quadrant of the abdomen, equal to or greater than bone marrow activity, was considered as a positive scan. Results: 36 out of 49 patients showing positive TC-WBC scans received appendectomy. They all proved to have positive pathological findings. Five positive TC-WBC were not related to acute appendicitis, because of other pathological lesions. Eight patients were not operated and clinical follow-up after one month revealed no acute abdominal condition. Three of 31 patients with negative TC-WBC scans received appendectomy. They also presented positive pathological findings. The remaining 28 patients did not receive operations and revealed no evidence of appendicitis after at least one month of follow-up. The overall sensitivity, specificity, accuracy, positive and negative predictive values for TC-WBC scan to diagnose acute appendicitis were 92, 78, 86, 82, and 90%, respectively. Conclusion: TC-WBC scan provides a rapid and highly accurate method for the diagnosis of acute appendicitis in patients with equivocal clinical examination. It proved useful in reducing the false-positive rate of laparotomy and shortens the time necessary for clinical observation.

High False-Positive Rate of a Putative Biomarker Test to Aid in the Diagnosis of Schizophrenia

2016 ◽  
Vol 77 (04) ◽  
pp. e451-e456 ◽  
Author(s):  
Cheryl A. Wehler ◽  
Sheldon H. Preskorn
Keyword(s):  
False Positive ◽  
False Positive Rate ◽  
High False Positive Rate ◽  
Positive Rate

Pulse oximetry screening for detection of congenital heart defects at 1646 m in Albuquerque, New Mexico

2020 ◽  
Vol 30 (12) ◽  
pp. 1851-1855
Author(s):  
Sruti Rao ◽  
M. B. Goens ◽  
Orrin B. Myers ◽  
Emilie A. Sebesta
Keyword(s):  
New Mexico ◽  
Pulse Oximetry ◽  
Sea Level ◽  
False Positive ◽  
False Positive Rate ◽  
False Positives ◽  
Moderate Altitude ◽  
High False Positive Rate ◽  
Positive Rate ◽  
Pulse Oximetry Screening

AbstractAim:To determine the false-positive rate of pulse oximetry screening at moderate altitude, presumed to be elevated compared with sea level values and assess change in false-positive rate with time.Methods:We retrospectively analysed 3548 infants in the newborn nursery in Albuquerque, New Mexico, (elevation 5400 ft) from July 2012 to October 2013. Universal pulse oximetry screening guidelines were employed after 24 hours of life but before discharge. Newborn babies between 36 and 36 6/7 weeks of gestation, weighing >2 kg and babies >37 weeks weighing >1.7 kg were included in the study. Log-binomial regression was used to assess change in the probability of false positives over time.Results:Of the 3548 patients analysed, there was one true positive with a posteriorly-malaligned ventricular septal defect and an interrupted aortic arch. Of the 93 false positives, the mean pre- and post-ductal saturations were lower, 92 and 90%, respectively. The false-positive rate before April 2013 was 3.5% and after April 2013, decreased to 1.5%. There was a significant decrease in false-positive rate (p = 0.003, slope coefficient = −0.082, standard error of coefficient = 0.023) with the relative risk of a false positive decreasing at 0.92 (95% CI 0.88–0.97) per month.Conclusion:This is the first study in Albuquerque, New Mexico, reporting a high false-positive rate of 1.5% at moderate altitude at the end of the study in comparison to the false-positive rate of 0.035% at sea level. Implementation of the nationally recommended universal pulse oximetry screening was associated with a high false-positive rate in the initial period, thought to be from the combination of both learning curve and altitude. After the initial decline, it remained steadily elevated above sea level, indicating the dominant effect of moderate altitude.

A High False-Positive Rate of Tuberculosis Associated with Aplisol: An Investigation among Health Care Workers

1994 ◽  
Vol 169 (3) ◽  
pp. 703-704 ◽  
Author(s):  
B. P. Lanphear ◽  
C. C. Linnemann ◽  
C. G. Cannon
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
False Positive ◽  
False Positive Rate ◽  
High False Positive Rate ◽  
Care Workers ◽  
Positive Rate

Routine Use of PET Scans After Completion of Therapy in Pediatric Hodgkin Disease Results in a High False Positive Rate

2007 ◽  
Vol 29 (9) ◽  
pp. 667 ◽  
Author(s):  
Jennifer M. Levine ◽  
Michael Weiner ◽  
Kara M. Kelly
Keyword(s):  
False Positive ◽  
False Positive Rate ◽  
Hodgkin Disease ◽  
High False Positive Rate ◽  
Positive Rate ◽  
Pet Scans

scholarly journals Commercial assays have high false positive rate

BMJ ◽  
1995 ◽  
Vol 310 (6975) ◽  
pp. 327-328 ◽  
Author(s):  
J. Bendig ◽  
V. Meurisse ◽  
S. Chambers
Keyword(s):  
False Positive ◽  
False Positive Rate ◽  
High False Positive Rate ◽  
Positive Rate

The High False Positive Rate of Inflammatory Bowel Disease Serologic Markers in Patients with Irritable Bowel Syndrome

2006 ◽  
Vol 101 ◽  
pp. S475-S476
Author(s):  
Allan H. Andrews ◽  
Brooks D. Cash ◽  
Dong H. Lee ◽  
Richard Saad ◽  
Jennifer Rai ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Irritable Bowel Syndrome ◽  
Bowel Disease ◽  
False Positive ◽  
False Positive Rate ◽  
High False Positive Rate ◽  
Serologic Markers ◽  
Positive Rate ◽  
Inflammatory Bowel ◽  
Irritable Bowel
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