Improving diagnosis of acute appendicitis with atypical findings by Tc-99m HMPAO leukocyte scan

2002 ◽  
Vol 41 (01) ◽  
pp. 37-41 ◽  
Author(s):  
S. Shung-Shung ◽  
S. Yu-Chien ◽  
Y. Mei-Due ◽  
W. Hwei-Chung ◽  
A. Kao
Keyword(s):  
Acute Appendicitis ◽  
False Positive ◽  
False Positive Rate ◽  
Accurate Method ◽  
Clinical Findings ◽  
Pathological Findings ◽  
Lower Quadrant ◽  
Predictive Values ◽  
Positive Rate

Summary Aim: Even with careful observation, the overall false-positive rate of laparotomy remains 10-15% when acute appendicitis was suspected. Therefore, the clinical efficacy of Tc-99m HMPAO labeled leukocyte (TC-WBC) scan for the diagnosis of acute appendicitis in patients presenting with atypical clinical findings is assessed. Patients and Methods: Eighty patients presenting with acute abdominal pain and possible acute appendicitis but atypical findings were included in this study. After intravenous injection of TC-WBC, serial anterior abdominal/pelvic images at 30, 60, 120 and 240 min with 800k counts were obtained with a gamma camera. Any abnormal localization of radioactivity in the right lower quadrant of the abdomen, equal to or greater than bone marrow activity, was considered as a positive scan. Results: 36 out of 49 patients showing positive TC-WBC scans received appendectomy. They all proved to have positive pathological findings. Five positive TC-WBC were not related to acute appendicitis, because of other pathological lesions. Eight patients were not operated and clinical follow-up after one month revealed no acute abdominal condition. Three of 31 patients with negative TC-WBC scans received appendectomy. They also presented positive pathological findings. The remaining 28 patients did not receive operations and revealed no evidence of appendicitis after at least one month of follow-up. The overall sensitivity, specificity, accuracy, positive and negative predictive values for TC-WBC scan to diagnose acute appendicitis were 92, 78, 86, 82, and 90%, respectively. Conclusion: TC-WBC scan provides a rapid and highly accurate method for the diagnosis of acute appendicitis in patients with equivocal clinical examination. It proved useful in reducing the false-positive rate of laparotomy and shortens the time necessary for clinical observation.

scholarly journals A Study of the Diagnostic Accuracy of an Existing Multivariable Test to Predict Shoulder Dystocia

2019 ◽  
Vol 09 (03) ◽  
pp. e262-e267
Author(s):  
Henry Alexander Easley ◽  
Todd Michael Beste
Keyword(s):  
Diagnostic Accuracy ◽  
Prediction Model ◽  
Study Design ◽  
False Positive ◽  
False Positive Rate ◽  
Shoulder Dystocia ◽  
The Other ◽  
Predictive Values ◽  
Positive Rate ◽  
Sensitivity Specificity

Objectives To evaluate the diagnostic accuracy of a multivariable prediction model, the Shoulder Screen (Perigen, Inc.), and compare it with the American College of Obstetricians and Gynecologists (ACOG) guidelines to prevent harm from shoulder dystocia. Study Design The model was applied to two groups of 199 patients each who delivered during a 4-year period. One group experienced shoulder dystocia and the other group delivered without shoulder dystocia. The model's accuracy was analyzed. The performance of the model was compared with the ACOG guideline. Results The sensitivity, specificity, positive, and negative predictive values of the model were 23.1, 99.5, 97.9, and 56.4%, respectively. The sensitivity of the ACOG guideline was 10.1%. The false-positive rate of the model was 0.5%. The accuracy of the model was 61.3%. Conclusion A multivariable prediction model can predict shoulder dystocia and is more accurate than ACOG guidelines.

scholarly journals LOW FALSE POSITIVE RATE OFKEPLERCANDIDATES ESTIMATED FROM A COMBINATION OFSPITZERAND FOLLOW-UP OBSERVATIONS

2015 ◽  
Vol 804 (1) ◽  
pp. 59 ◽  
Author(s):  
Jean-Michel Désert ◽  
David Charbonneau ◽  
Guillermo Torres ◽  
François Fressin ◽  
Sarah Ballard ◽  
...  
Keyword(s):  
False Positive ◽  
False Positive Rate ◽  
Positive Rate

scholarly journals Using Z-score to optimize population-specific DDH screening: a retrospective study in Hangzhou, China

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Haomin Li ◽  
Liqi Shu ◽  
Jin Yu ◽  
Zeng Xian ◽  
Huilong Duan ◽  
...  
Keyword(s):  
False Positive ◽  
False Positive Rate ◽  
Developmental Dysplasia ◽  
Z Score ◽  
Local Regression ◽  
X Ray ◽  
Positive Rate ◽  
Z Scores ◽  
Highly Correlated

Abstract Background DDH (Developmental Dysplasia of the Hip) screening can potentially avert many morbidities and reduce costs. The debate about universal vs. selective DDH ultrasonography screening in different countries revolves to a large extent around effectiveness, cost, and the possibility of overdiagnosis and overtreatment. In this study, we proposed and evaluated a Z-score enhanced Graf method to optimize population-specific DDH screening. Methods A total of 39,710 history ultrasonography hip examinations were collected to establish a sex, side specific and age-based Z-scores model using the local regression method. The correlation between Z-scores and classic Graf types was analyzed. Four thousand two hundred twenty-nine cases with follow-up ultrasonographic examinations and 5284 cases with follow-up X-ray examinations were used to evaluate the false positive rate of the first examination based on the subsequent examinations. The results using classic Graf types and the Z-score enhanced types were compared. Results The Z-score enhanced Graf types were highly correlated with the classic Graf’s classification (R = 0.67, p < 0.001). Using the Z-scores ≥2 as a threshold could reduce by 86.56 and 80.44% the false positives in the left and right hips based on the follow-up ultrasonographic examinations, and reduce by 78.99% false-positive cases based on the follow-up X-ray examinations, respectively. Conclusions Using an age, sex and side specific Z-scores enhanced Graf’s method can better control the false positive rate in DDH screening among different populations.

scholarly journals Follow-Up SARS-CoV-2 PCR Testing Outcomes From a Large Reference Lab in the US

2021 ◽  
Vol 9 ◽  
Author(s):  
Adam Sullivan ◽  
David Alfego ◽  
Brian Poirier ◽  
Jonathan Williams ◽  
Dorothy Adcock ◽  
...  
Keyword(s):  
United States ◽  
Cohort Study ◽  
False Positive ◽  
False Positive Rate ◽  
The United States ◽  
Positive Test ◽  
Test Results ◽  
Rt Pcr ◽  
Positive Rate

By analyzing COVID-19 sequential COVID-19 test results of patients across the United States, we herein attempt to quantify some of the observations we've made around long-term infection (and false-positive rates), as well as provide observations on the uncertainty of sampling variability and other dynamics of COVID-19 infection in the United States. Retrospective cohort study of a registry of RT-PCR testing results for all patients tested at any of the reference labs operated by Labcorp® including both positive, negative, and inconclusive results, from March 1, 2020 to January 28, 2021, including patients from all 50 states and outlying US territories. The study included 22 million patients with RT-PCR qualitative test results for SARS-CoV-2, of which 3.9 million had more than one test at Labcorp. We observed a minuscule &lt;0.1% basal positive rate for follow up tests &gt;115 days, which could account for false positives, long-haulers, and/or reinfection but is indistinguishable in the data. In observing repeat-testing, for patients who have a second test after a first RT-PCR, 30% across the cohort tested negative on the second test. For patients who test positive first and subsequently negative within 96 h (40% of positive test results), 18% of tests will subsequently test positive within another 96-h span. For those who first test negative and then positive within 96 h (2.3% of negative tests), 56% will test negative after a third and subsequent 96-h period. The sudden changes in RT-PCR test results for SARS-CoV-2 from this large cohort study suggest that negative test results during active infection or exposure can change rapidly within just days or hours. We also demonstrate that there does not appear to be a basal false positive rate among patients who test positive &gt;115 days after their first RT-PCR positive test while failing to observe any evidence of widespread reinfection.

scholarly journals Audit of the first > 7500 noninvasive prenatal aneuploidy tests in a Swiss genetics center

2021 ◽  
Author(s):  
Anahita Bajka ◽  
Michael Bajka ◽  
Fabian Chablais ◽  
Tilo Burkhardt
Keyword(s):  
Pregnancy Outcome ◽  
False Positive Rate ◽  
Prenatal Testing ◽  
Accurate Method ◽  
Test Results ◽  
Data Set ◽  
Single Nucleotide ◽  
Noninvasive Prenatal Testing ◽  
Positive Rate

Abstract Objectives Noninvasive prenatal testing (NIPT) is actually the most accurate method of screening for fetal chromosomal aberration (FCA). We used pregnancy outcome record to evaluate a complete data set of single nucleotide polymorphism-based test results performed by a Swiss genetics center. Materials and methods The Panorama® test assesses the risk of fetal trisomies (21, 18 and 13), gonosomal aneuploidy (GAN), triploidy or vanishing twins (VTT) and five different microdeletions (MD). We evaluated all 7549 test results meeting legal and quality requirements taken in women with nondonor singleton pregnancies between April 2013 and September 2016 classifying them as high or low risk. Follow-up ended after 9 months, data collection 7 months later. Results The Panorama® test provided conclusive results in 96.1% of cases, detecting 153 FCA: T21 n = 76, T18 n = 19, T13 n = 15, GAN n = 19, VTT n = 13 and MD n = 11 (overall prevalence 2.0%). Pregnancy outcome record was available for 68.6% of conclusive laboratory results, including 2.0% high-risk cases. In this cohort the Panorama® test exhibited 99.90% sensitivity for each trisomy; specificity was 99.90% for T21, 99.98% for T18 and 99.94% for T13. False positive rate was 0.10% for T21, 0.02% for T18 and 0.06% for T13. Conclusion SNP-based testing by a Swiss genetics center confirms the expected accuracy of NIPT in FCA detection.

scholarly journals Screening for Hypertensive Pregnancy Complications through Maternal Serum PAPP-A 5th and 10th Percentiles during the 11-14 Weeks Gestational Age Interval

2020 ◽  
Vol 71 (2) ◽  
pp. 262-266
Author(s):  
Voicu Dascau ◽  
Gheorghe Furau ◽  
Luminita Pilat ◽  
Cristina Onel ◽  
Maria Puschita
Keyword(s):  
Gestational Age ◽  
Predictive Value ◽  
False Positive ◽  
False Positive Rate ◽  
Protein A ◽  
Maternal Serum ◽  
Predictive Values ◽  
Induced Hypertension ◽  
Positive Rate ◽  
Mild Preeclampsia

The aim of our study was to assess the predictive values for hypertensive complications of pregnancy of the multiples of median (MoM) of serum pregnancy associated plasma protein A (PAPP-A), measured in 128 pregnant patients between 11 and 14 weeks gestational age. The 5th and the 10th percentile for MoM PAPP-A were 0.27 and 0.33, respectively. The detection rate for pregnancy induced hypertension, mild preeclampsia, severe preeclampsia, all preeclampsia and all hypertensive complications was 0%, 9.09%, 0%, 7.69%, and 6.25% for MoM PAPP-A below the 5th percentile (for a false positive rate of 5%), and 33.33%, 9.09%, 0%, 7.69%, and 12.5% for MoM PAPP-A below the 10th percentile (for a false positive rate of 10%), respectively. The specificity ranged from 89.57% to 95.73%, the positive predictive value from 0% to 16.67%, and the negative predictive value from 87.70% to 98.36%.

Follow‐up program for blood donors with unconfirmed screening results reveals a high false‐positive rate in Dalian, China

Transfusion ◽  
2020 ◽  
Vol 60 (2) ◽  
pp. 334-342
Author(s):  
Xuelian Deng ◽  
Liang Zang ◽  
Xinmei Wang ◽  
Hui Chen ◽  
Jiangdi Liu ◽  
...  
Keyword(s):  
False Positive ◽  
Blood Donors ◽  
False Positive Rate ◽  
High False Positive Rate ◽  
Positive Rate

Evaluation of whole-body FDG-PET in breast cancer screening.

2011 ◽  
Vol 29 (27_suppl) ◽  
pp. 66-66
Author(s):  
S. Nishizawa ◽  
H. Kodama ◽  
H. Okada
Keyword(s):  
Fdg Pet ◽  
Screening Program ◽  
False Positive Rate ◽  
Whole Body ◽  
Breast Cancers ◽  
Initial Screening ◽  
Predictive Values ◽  
Negative Results ◽  
Positive Rate

66 Background: The utility of whole-body FDG-PET for the detection of breast cancers in a screening program is not well investigated. Methods: We analyzed data from a cancer screening program including whole-body FDG-PET performed for consecutive 2065 asymptomatic women (age: 40 to 80 y.o. with mean ± SD of 56.1 ± 8.6 y.o.) without a previous history of breast cancer. They underwent the initial screening between September 2003 and December 2008. The screening included neither mammography nor ultrasonography of the breast. Final results of cancers and/or follow-up data more than 1 year following the screening were available in 1822 of the 2065 (88.2%: 941 by the following screening and 881 by the response to questionnaires). Data of the second screening in 670 women (age: 55.0 ± 8.0 y.o.) of the 941, who didn’t have cancer at the initial screening and received the second screening by December 2008 and within 2 years of the initial screening were also analyzed. Final results and/or follow-up data more than 1 year were available in 642 of the 670 (95.8%: 573 by a subsequent screening and 69 by the response to questionnaires). Results: Data were analyzed as of the end of 2010. In 2 years after the initial screening, 57 cancers of a variety of organs including 12 of the breast were confirmed. Nine (stage 0: 1, I: 7 and IIA: 1) of the 12 were proven in 29 women with PET positive results and 3 (stage I: 1, IIA: 1 and not available: 1) in 2036 women with PET negative results. In 2 years after the second screening, 9 cancers including 4 of the breast were confirmed. Three of the 4 (stage 0: 1, I: 1 and IIB: 1) were diagnosed in 9 women with PET positive results and 1 (stage I) in 661 with PET negative results. Two of the 4 PET negative cancers were diagnosed after developing symptoms and the remaining 2 were detected by another screening. Sensitivity, specificity, positive and negative predictive values and false positive rate of the initial screening were 75.0% (9/12), 99.0% (2033/2053), 31.0% (9/29), 99.9% (2033/2036) and 1.0% (20/2053), respectively. Conclusions: Whole-body FDG-PET had the capability to screen the breast with a very low false positive rate and high positive and negative predictive values, and could detect breast cancers of asymptomatic women at early stages with reasonable sensitivity.

scholarly journals SIMULATION OF A COMBINED SZE AND WEAK LENSING CLUSTER SURVEY FOR AMIBA EXPERIMENT

2004 ◽  
Vol 19 (13n16) ◽  
pp. 1027-1030 ◽  
Author(s):  
KEIICHI UMETSU ◽  
TZIHONG CHIUEH ◽  
KAI-YANG LIN ◽  
JUN-MEIN WU ◽  
YAO-HUAN TSENG
Keyword(s):  
False Positive ◽  
High Redshift ◽  
False Positive Rate ◽  
Weak Lensing ◽  
Clusters Of Galaxies ◽  
Cluster Survey ◽  
Sunyaev Zel'dovich Effect ◽  
Positive Rate ◽  
Number Counts

We present simulations of interferometric Sunyaev-Zel'dovich effect (SZE) and optical weak lenisng observations for the forthcoming AMiBA experiment, aiming at searching for high-redshift clusters of galaxies. On the basis of simulated sky maps, we have derived theoretical halo number counts and redshift distributions of selected halo samples for an AMiBA SZE survey and a weak lensing follow-up survey. By utilizing the conditional number counts of weak lensing halos with the faint SZE detection, we show that a combined SZE and weak lensing survey can gain an additional fainter halo sample at a given false positive rate, which cannot be obtained from either survey alone.

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