scholarly journals Assessment of Liaison XL Murex Chagas diagnostic performance in blood screening for Chagas disease using a reference array of chimeric antigens

Transfusion ◽  
2021 ◽  
Author(s):  
Emily F. Santos ◽  
Leonardo M. Leony ◽  
Ângelo A. O. Silva ◽  
Ramona T. Daltro ◽  
Natália E. M. Freitas ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Diagnostic Performance ◽  
Reference Array ◽  
Blood Screening

scholarly journals Cross-Reactivity Using Chimeric Trypanosoma cruzi Antigens: Diagnostic Performance in Settings Where Chagas Disease and American Cutaneous or Visceral Leishmaniasis Are Coendemic

2019 ◽  
Vol 57 (8) ◽  
Author(s):  
Ramona Tavares Daltro ◽  
Leonardo Maia Leony ◽  
Natália Erdens Maron Freitas ◽  
Ângelo Antônio Oliveira Silva ◽  
Emily Ferreira Santos ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Chagas Disease ◽  
Diagnostic Performance ◽  
Latent Class ◽  
Cross Reactivity ◽  
Chimeric Proteins ◽  
Serum Samples ◽  
Perfect Agreement ◽  
Content Type ◽  
Chronic Chagas Disease

ABSTRACT Chimeric T. cruzi antigens have been proposed as a diagnostic tool for chronic Chagas disease (CD) in both settings where Chagas disease is endemic and those where it is not endemic. Antibody response varies in accordance to each T. cruzi strain, presenting challenges to the use of antigens lacking demonstrated cross-reactivity with Leishmania spp. Our group expressed four chimeric proteins (IBMP-8.1, IBMP-8.2, IBMP-8.3, and IBMP-8.4) and previously assessed their diagnostic performance to determine cross-reactivity with Leishmania spp. Here, we validated our findings using serum samples from different Brazilian geographic areas reporting endemic Chagas disease, endemic visceral or American cutaneous leishmaniasis (ACL), or both. Overall, 829 serum samples were evaluated using commercial and IBMP enzyme-linked immunosorbent assays. Due to the absence of a reference assay to diagnosis CD, latent class analysis (LCA) was performed through the use of a statistical model. The incidence of cross-reactivity for ACL-positive samples varied from 0.35% (IBMP-8.3) to 0.70% (IBMP-8.1 and IBMP-8.2). Regarding visceral leishmaniasis (VL)-positive samples, the IBMP-8.2 and IBMP-8.3 antigens cross-reacted with six (3.49%) and with only one sample (0.58%), respectively. No cross-reactivity with either ACL or VL was observed for the IBMP-8.4 antigen. Similarly, no cross-reactions were found when VL-positive samples were assayed with IBMP-8.1. The agreement among the results obtained using IBMP antigens ranged from 97.3% for IBMP-8.2 and 99% for IBMP-8.1 and IBMP-8.3 to 100% for IBMP-8.4, demonstrating almost perfect agreement with LCA. Accordingly, in light of the negligible cross-reactivity with both ACL and VL, we suggest the use of IBMP antigens in regions where T. cruzi and Leishmania spp. are coendemic.

Diagnostic performance of tests based on Trypanosoma cruzi excreted–secreted antigens in an endemic area for Chagas' disease in Bolivia

2007 ◽  
Vol 57 (2) ◽  
pp. 229-232 ◽  
Author(s):  
Carlos Rodrigo Zarate-Blades ◽  
Nelly Bladés ◽  
Marilda Savoia Nascimento ◽  
José Franco da Silveira ◽  
Eufrosina Setsu Umezawa
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Diagnostic Performance ◽  
Endemic Area ◽  
Secreted Antigens

706 B-type natriuretic peptide (BNP) and ventricular arrhythmias in Chagas disease

2007 ◽  
Vol 6 (1) ◽  
pp. 155-156
Author(s):  
J MARQUES ◽  
A KANSKY ◽  
I MENDOZA ◽  
L LOPEZGOMEZ ◽  
F MOLEIRO ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Chagas Disease ◽  
Ventricular Arrhythmias

Chagas Disease After Organ Transplantation - Los Angeles, California, 2006

2006 ◽  
Author(s):  
L. Mascola ◽  
B. Kubak ◽  
S. Radhakrishna ◽  
T. Mone ◽  
R. Hunter ◽  
...  
Keyword(s):  
Los Angeles ◽  
Organ Transplantation ◽  
Chagas Disease

Validity and Diagnostic Performance of Depression Scales With Latina/o Undergraduates

2009 ◽  
Author(s):  
Marlen Kanagui ◽  
Melissa A. Rico ◽  
Jeanett Castellanos ◽  
Alberta M. Gloria
Keyword(s):  
Diagnostic Performance ◽  
Depression Scales

Cha 912, a new human cross-reactive antigen in Chagas' disease

1997 ◽  
Vol 56 (1-3) ◽  
pp. 429
Author(s):  
C Rodríguez
Keyword(s):  
Chagas Disease

(-)-Cubebin and (-)-Hinokinin: Evaluation of immunomodulatory effects in Chagas' disease

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
VR Esperandim ◽  
DS Ferreira ◽  
KCS Rezende ◽  
R Lucarini ◽  
LGR Oliveira ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Immunomodulatory Effects

DIAGNOSTIC PERFORMANCE OF COLON CAPSULE ENDOSCOPY (CCE2). A PROSPECTIVE MULTICENTER STUDY IN A SCREENING SETTING

2018 ◽  
Author(s):  
C Spada ◽  
C Hassan ◽  
M Pennazio ◽  
Z Adrián-de-Ganzo ◽  
E Rondonotti ◽  
...  
Keyword(s):  
Capsule Endoscopy ◽  
Multicenter Study ◽  
Diagnostic Performance ◽  
Prospective Multicenter Study ◽  
Colon Capsule Endoscopy ◽  
Colon Capsule
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