Use of routine histopathology and factor VIII-related antigen/von Willebrand factor immunohistochemistry to differentiate primary hemangiosarcoma of bone from telangiectatic osteosarcoma in 54 dogs

2016 ◽  
Vol 15 (4) ◽  
pp. 1232-1239 ◽  
Author(s):  
M. A. Giuffrida ◽  
N. J. Bacon ◽  
D. A. Kamstock
Keyword(s):  
Factor Viii ◽  
Von Willebrand Factor ◽  
Telangiectatic Osteosarcoma ◽  
Factor Viii Related Antigen ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals Selective absence of large forms of factor VIII/von Willebrand factor in acquired von Willebrand's syndrome. Response to transfusion

Blood ◽  
1979 ◽  
Vol 54 (3) ◽  
pp. 600-606 ◽  
Author(s):  
D Meyer ◽  
D Frommel ◽  
MJ Larrieu ◽  
TS Zimmerman
Keyword(s):  
Factor Viii ◽  
Von Willebrand Factor ◽  
Von Willebrand Disease ◽  
Procoagulant Activity ◽  
Factor Viii Related Antigen ◽  
Cofactor Activity ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Ristocetin Cofactor ◽  
Ristocetin Cofactor Activity

Abstract A previously healthy elderly man with mucocutaneous bleeding was found to have a benign monoclonal IgG gammapathy associated with criteria for severe von Willebrand disease (Factor VIII procoagulant activity, Factor-VIII-related antigen, and ristocetin cofactor activity, less than 10% of normal). Associated qualitative abnormalities of factor VIII/von Willebrand factor were demonstrated by radiocrossed immunoelectrophoresis and immunoradiometric assay. The late clinical onset and negative family history are in favor of an acquired form of vWD. The monoclonal gammapathy and abnormalities of factor VIII/von Willebrand factor have been stable over a 10-yr period. No inhibitor to Factor VIII procoagulant activity, ristocetin cofactor activity, or Factor-VIII-related antigen could be demonstrated. Following transfusion of cryoprecipitate (with a normal cross immunoelectrophoretic pattern), there was a rapid removal of the large forms of Factor.-VIII-related antigen, paralleled by a decay of ristocetin cofactor activity. The transfusion study of this patient with acquired von Willebrand disease type II (variant of von Willebrand disease) serves to emphasize the relationship between polydispersity of Factor VIII/von Willebrand Factor and functional heterogeneity.

Immunoquantitation of factor VIII-related antigen (Von Willebrand factor antigen) in prostate cancer

1988 ◽  
Vol 40 (3) ◽  
pp. 283-289 ◽  
Author(s):  
Richard J. Ablin ◽  
John M. Bartkus ◽  
Maurice J. Gonder
Keyword(s):  
Prostate Cancer ◽  
Factor Viii ◽  
Von Willebrand Factor ◽  
Factor Viii Related Antigen ◽  
Von Willebrand Factor Antigen ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen

Factor VIII Procoagulant Activity, Factor VIII Related Antigen and von Willebrand Factor in Newborn Cord Blood

1979 ◽  
Vol 42 (4) ◽  
pp. 637-646 ◽  
Author(s):  
H. Fukui ◽  
T. Takase ◽  
H. Ikari ◽  
Y. Murakami ◽  
Y. Ōkubo ◽  
...  
Keyword(s):  
Factor Viii ◽  
Cord Blood ◽  
Von Willebrand Factor ◽  
Procoagulant Activity ◽  
Factor Viii Related Antigen ◽  
Activity Factor ◽  
Von Willebrand ◽  
Willebrand Factor

VON WILLEBRAND FACTOR AND FACTOR-VIII-RELATED ANTIGEN

The Lancet ◽  
1974 ◽  
Vol 303 (7859) ◽  
pp. 685 ◽  
Author(s):  
Penelope Stableforth ◽  
T.W. Barrowcliffe ◽  
Katharine Dormandy
Keyword(s):  
Factor Viii ◽  
Von Willebrand Factor ◽  
Factor Viii Related Antigen ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals Selective absence of large forms of factor VIII/von Willebrand factor in acquired von Willebrand's syndrome. Response to transfusion

Blood ◽  
1979 ◽  
Vol 54 (3) ◽  
pp. 600-606
Author(s):  
D Meyer ◽  
D Frommel ◽  
MJ Larrieu ◽  
TS Zimmerman
Keyword(s):  
Factor Viii ◽  
Von Willebrand Factor ◽  
Von Willebrand Disease ◽  
Procoagulant Activity ◽  
Factor Viii Related Antigen ◽  
Cofactor Activity ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Ristocetin Cofactor ◽  
Ristocetin Cofactor Activity

A previously healthy elderly man with mucocutaneous bleeding was found to have a benign monoclonal IgG gammapathy associated with criteria for severe von Willebrand disease (Factor VIII procoagulant activity, Factor-VIII-related antigen, and ristocetin cofactor activity, less than 10% of normal). Associated qualitative abnormalities of factor VIII/von Willebrand factor were demonstrated by radiocrossed immunoelectrophoresis and immunoradiometric assay. The late clinical onset and negative family history are in favor of an acquired form of vWD. The monoclonal gammapathy and abnormalities of factor VIII/von Willebrand factor have been stable over a 10-yr period. No inhibitor to Factor VIII procoagulant activity, ristocetin cofactor activity, or Factor-VIII-related antigen could be demonstrated. Following transfusion of cryoprecipitate (with a normal cross immunoelectrophoretic pattern), there was a rapid removal of the large forms of Factor.-VIII-related antigen, paralleled by a decay of ristocetin cofactor activity. The transfusion study of this patient with acquired von Willebrand disease type II (variant of von Willebrand disease) serves to emphasize the relationship between polydispersity of Factor VIII/von Willebrand Factor and functional heterogeneity.

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