Progenitor cells expressing nestin, a neural crest stem cell marker, differentiate into outer root sheath keratinocytes

2019 ◽  
Vol 30 (5) ◽  
pp. 365 ◽  
Author(s):  
Saki Onishi ◽  
Yuta Baba ◽  
Fumika Yokoi ◽  
Kaori Ide ◽  
Manabu Ohyama ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Crest ◽  
Progenitor Cells ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Outer Root Sheath ◽  
Neural Crest Stem Cell ◽  
Root Sheath ◽  
Outer Root Sheath Keratinocytes

Abstract 2045: Identifying key molecular events at the onset of melanoma using a neural crest stem cell marker

2014 ◽  
Author(s):  
Charles K. Kaufman ◽  
Christian Mosimann ◽  
Richard M. White ◽  
Dominic Matos ◽  
Leonard I. Zon
Keyword(s):  
Stem Cell ◽  
Neural Crest ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Neural Crest Stem Cell ◽  
Molecular Events

CD114: A New Member of the Neural Crest-Derived Cancer Stem Cell Marker Family

2016 ◽  
Vol 118 (2) ◽  
pp. 221-231 ◽  
Author(s):  
Peter E. Zage ◽  
Sarah B. Whittle ◽  
Jason M. Shohet
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Neural Crest ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals Fibrin acts as biomimetic niche inducing both differentiation and stem cell marker expression of early human endothelial progenitor cells

2010 ◽  
Vol 44 (1) ◽  
pp. 33-48 ◽  
Author(s):  
M. C. Barsotti ◽  
A. Magera ◽  
C. Armani ◽  
F. Chiellini ◽  
F. Felice ◽  
...  
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Endothelial Progenitor ◽  
Marker Expression ◽  
Biomimetic Niche ◽  
Early Human

scholarly journals Progenitor Cells from Cartilage: Grade Specific Differences in Stem Cell Marker Expression

2017 ◽  
Vol 18 (8) ◽  
pp. 1759 ◽  
Author(s):  
Marija Mazor ◽  
Annabelle Cesaro ◽  
Mazen Ali ◽  
Thomas Best ◽  
Eric Lespessaille ◽  
...  
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Marker Expression

Progenitor cells from cartilage-No osteoarthritis-grade-specific differences in stem cell marker expression

2012 ◽  
Vol 29 (1) ◽  
pp. 206-212 ◽  
Author(s):  
Peter Bernstein ◽  
Ines Sperling ◽  
Denis Corbeil ◽  
Ute Hempel ◽  
Stefan Fickert
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Marker Expression

Tunneling nanotubes mediate the transfer of stem cell marker CD133 between hematopoietic progenitor cells

2016 ◽  
Vol 44 (11) ◽  
pp. 1092-1112.e2 ◽  
Author(s):  
Doreen Reichert ◽  
Julia Scheinpflug ◽  
Jana Karbanová ◽  
Daniel Freund ◽  
Martin Bornhäuser ◽  
...  
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Stem Cell Marker ◽  
Hematopoietic Progenitor Cells ◽  
Cell Marker ◽  
Hematopoietic Progenitor ◽  
Tunneling Nanotubes

scholarly journals OR19-02 Luteinizing Hormone/Human Chorionic Gonadotropin Receptor Protein Expression in Adrenocortical Progenitor Cells, Aldosterone Producing Cell Clusters and Adrenal Adenomas Derived from Postmenopausal Women

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Effie Tsomos ◽  
Regina Belokovskaya ◽  
Jose Sanchez Escobar ◽  
Shen Yao ◽  
Kazutaka Nanba ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Postmenopausal Women ◽  
Progenitor Cells ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Immunohistochemical Expression ◽  
Cell Clusters ◽  
Blinded Fashion ◽  
Archival Specimens

Abstract Objective/Background Adrenal pathologies are more common in women than men. Embryologically the adrenals and gonads develop from the adrenogenital ridge with differential migration and differentiation. We hypothesized that in adult females there are adrenocortical progenitor cells that express the LH/hCG-R and proliferate in response to elevated LH. Indeed, several case reports demonstrated LH/hCG-R expression in adrenal secretory tumors in postmenopausal and pregnant females. In aging adults, nests of cells known as aldosterone-producing cell clusters (APCCs) that may be precursors to aldosterone producing adenomas are frequently detected. We retrospectively studied the immunohistochemical expression of LH/hCG-R in normal adrenals, adrenal adenomas and APCCs in archival specimens derived from post-menopausal women. Methods Archival specimens from adrenal adenomas derived from 23 women >55 years of age were examined. Clinical data was obtained in a blinded fashion and hormonal data was available in 9/23 cases; 6/9 were secreting cortisol and 3/9 adenomas were secreting aldosterone. In addition, 6 samples derived from a repository of normal adrenal tissues from deceased kidney donors (1 male, and 5 postmenopausal females) were studied. All specimens were immunostained for LH/hCG-R and the adrenal stem cell marker DLK1 that facilitates the maintenance of an undifferentiated phenotype. The normal adrenal tissues were also stained for aldosterone synthase (CYP11B2) to detect APCCs. The slides were reviewed and graded by a pathologist in a blinded fashion. Results Expression of LH/hCG-R was demonstrated in both normal and adenomatous tissues in all 23 specimens. The staining in adenomas was heterogeneous, with clusters of densely stained LH/hCG-R positive cells in all specimens. There were less densely stained clusters in normal adjacent adrenocortical tissue that was most prominent in the subcapsular, zona glomerulosa region, an area where the putative adrenal cortical stem cells are found as well as the zona reticularis. Double staining for the stem cell marker DLK1 and LH/hCG-R confirmed that these cells represent adrenocortical progenitor cells. CYP 11B2 immunohistochemistry of normal adrenals demonstrated cell foci dipping from the capsule into the zona fasciculata classified as APCCs that co-expressed cytoplasmic LH/hCGR. Conclusion Adrenal adenomas and APCCs derived from postmenopausal women exhibited heterogeneous but strong immunohistochemical expression of LH/hCG-R in all samples. Interestingly, DLK1-positive adrenocortical stem cells in the subcapsular zone also expressed LH/hCG-R. These data may provide insights into the female predominance of adrenal pathologies, particularly in postmenopausal women with high LH levels. The LH/hCG-R may be a viable target for treatment of adrenal adenomas in postmenopausal women.

scholarly journals Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1

2007 ◽  
Vol 176 (4) ◽  
pp. 483-495 ◽  
Author(s):  
Véronique Dubreuil ◽  
Anne-Marie Marzesco ◽  
Denis Corbeil ◽  
Wieland B. Huttner ◽  
Michaela Wilsch-Bräuninger
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Primary Cilium ◽  
Neural Progenitors ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Membrane Particles ◽  
Membrane Microdomain ◽  
Neuroepithelial Cells ◽  
Stem And Progenitor Cells

Expansion of the neocortex requires symmetric divisions of neuroepithelial cells, the primary progenitor cells of the developing mammalian central nervous system. Symmetrically dividing neuroepithelial cells are known to form a midbody at their apical (rather than lateral) surface. We show that apical midbodies of neuroepithelial cells concentrate prominin-1 (CD133), a somatic stem cell marker and defining constituent of a specific plasma membrane microdomain. Moreover, these apical midbodies are released, as a whole or in part, into the extracellular space, yielding the prominin-1–enriched membrane particles found in the neural tube fluid. The primary cilium of neuroepithelial cells also concentrates prominin-1 and appears to be a second source of the prominin-1–bearing extracellular membrane particles. Our data reveal novel origins of extracellular membrane traffic that enable neural stem and progenitor cells to avoid the asymmetric inheritance of the midbody observed for other cells and, by releasing a stem cell membrane microdomain, to potentially influence the balance of their proliferation versus differentiation.

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