scholarly journals Complement blockade with eculizumab to treat acute symptomatic humoral rejection after heart transplantation

2022 ◽  
Author(s):  
Patrick Yerly ◽  
Samuel Rotman ◽  
Julien Regamey ◽  
Vincent Aubert ◽  
Stefania Aur ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Humoral Rejection

ACUTE HUMORAL REJECTION AFTER HEART TRANSPLANTATION

1988 ◽  
Vol 46 (4) ◽  
pp. 603-604 ◽  
Author(s):  
GEORGE JAMBROES ◽  
JAN C. C. BORLEFFS ◽  
PIETER J. SLOOTWEG ◽  
FRITS H. J. GMELIG MEYLING ◽  
GIJSBERT C. DE GAST
Keyword(s):  
Heart Transplantation ◽  
Humoral Rejection

scholarly journals Rat-to-Chinese tree shrew heart transplantation is a novel small animal model to study non-Gal-mediated discordant xenograft humoral rejection

2015 ◽  
Vol 22 (6) ◽  
pp. 468-475 ◽  
Author(s):  
WeiLi Chen ◽  
Yuan Wu ◽  
Akira Shimizu ◽  
YinLong Lian ◽  
Masayuki Tasaki ◽  
...  
Keyword(s):  
Animal Model ◽  
Heart Transplantation ◽  
Tree Shrew ◽  
Small Animal ◽  
Humoral Rejection ◽  
Small Animal Model

scholarly journals 1186 Three-dimensional analysis of right ventricle strain in transplanted hearts and rejection: an ongoing prospective study

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
RCPLD Costa ◽  
A C T Rodrigues ◽  
C H Fischer ◽  
E B Lira-Filho ◽  
C G Monaco ◽  
...  
Keyword(s):  
Ejection Fraction ◽  
Right Ventricle ◽  
Heart Transplantation ◽  
Three Dimensional ◽  
Posterior Wall ◽  
Tissue Doppler ◽  
Left Ventricular ◽  
Free Wall ◽  
Humoral Rejection ◽  
Cellular Rejection

Abstract Background The main obstacle for success after heart transplantation is graft rejection, since is mainly asymptomatic and diagnosed by endomyocardial biopsy (EMB). New echocardiographic technologies could bring benefits to that population if subtle changes in heart mechanics were related to an incipient state of rejection. Purpose To quantify echocardiographic parameters of right ventricle strain and volumes by a semi-automated offline software and to identify the presence of any relation between those findings and the histopathologic diagnose of rejection. Methods a prospective cohort of 35 postoperative heart transplant patients who were submitted to echocardiographic evaluation up to six hours after EMB, including two-dimensional chamber quantification of left ventricular (LV) volumes and ejection fraction; conventional and tissue Doppler measurements were used for flow and functional analysis. Offline assessment of the right ventricle (RV) was made by TOMTEC software, with the acquisition of RV volumes (EDV, ESV, SV) and ejection fraction, TAPSE, FAC and three-dimensional(3D) RV free wall and septal strain using speckle tracking. EMB results were classified as positive for cellular rejection if graded as 2R (two or more interstitial infiltrate spots and myocyte damage) and positive for humoral rejection if they show any response by immunofluorescence assay. Results We studied 35 patients, aged 50 ±11, 21 male (67%), totaling 58 examinations, and then we made two analysis of EMB: one in two groups regarding cellular rejection (53 negative and 5 positive) and other regarding humoral rejection (50 negative and 8 positive). RVEDV was higher in the cellular rejection group (112,5 ± 29,6 ml) compared to those with negative biopsy (86,8 ± 24,7 mL; p = 0,01). RV stroke volume showed a similar behavior (53,5 ± 22,3 mL vs. 34,5 ± 11,3 mL; p < 0,01). Regarding humoral rejection by immunofluorescence, patients who tested positive showed lower RVEDV (79,5 ± 10,5 mL vs. 90,57 ± 27,31 mL; p = 0,02) and RVESV (45,53 ± 6,33 mL vs. 53,87 ± 19,87 mL; p = 0,01). RV free wall strain was lower in the group with positive immunofluorescence (-18,35 ± 2,79% vs. -15,34 ± 5,35%; p = 0,01). Regarding 2D measurements , interventricular septal (11,5 ± 1,06 mm vs. 10,56 ± 1,38 mm; p = 0,02) and left ventricular posterior wall (10,75 ± 1,03 mm vs. 10,04 ± 1,1 mm; p = 0,05) were also thicker in the group with positive immunofluorescence for rejection. Conclusion Both cellular and humoral rejection after heart transplantation are associated to increased 3D RV volumes whereas a decrease in RV free wall strain is only observed in humoral rejection; in patients with positive immunofluorescence results a significant increase is seen for septal and posterior wall thickness.

Plasmapheresis and cyclophosphamide in the treatment of humoral rejection after heart transplantation

2001 ◽  
Vol 20 (3) ◽  
pp. 316-321 ◽  
Author(s):  
Onnen Grauhan ◽  
Christoph Knosalla ◽  
Ralf Ewert ◽  
Manfred Hummel ◽  
Matthias Loebe ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Humoral Rejection

scholarly journals Humoral rejection after heart transplantation: reliability of intramyocardial electrogram recordings (IMEG) and myocardial biopsy

1997 ◽  
Vol 10 (6) ◽  
pp. 439-445 ◽  
Author(s):  
O. Grauhan ◽  
J. Miiller ◽  
R. Pfitzmann ◽  
C. Knosalla ◽  
H. Siniawski ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Humoral Rejection ◽  
Myocardial Biopsy
Sign in / Sign up

Export Citation Format

Share Document