scholarly journals Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia

2021 ◽  
Author(s):  
Joseph Barlow ◽  
Pagona Panagiota Sfyri ◽  
Rob Mitchell ◽  
Sandrine Verpoorten ◽  
David Scully ◽  
...  
Keyword(s):  
Mouse Model ◽  
Muscle Regeneration ◽  
Platelet Releasate

A20 Assessment of muscle regeneration in the R6/2 mouse model of huntington’s disease

2021 ◽  
Author(s):  
Sanzana Hoque ◽  
Rana Soylu Kucharz ◽  
Valérie Allamand ◽  
Marie Sjögren ◽  
Kinga Gawlik ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Muscle Regeneration

Satellite cell content and muscle regeneration is impaired in a mouse model of NAFLD

Nutrition ◽  
2021 ◽  
pp. 111570
Author(s):  
Tolulope Peter Saliu ◽  
Thanutchaporn Kumrungsee ◽  
Koji Mitsumoto ◽  
Siyi Chen ◽  
Noriyuki Yanaka
Keyword(s):  
Mouse Model ◽  
Satellite Cell ◽  
Muscle Regeneration ◽  
Cell Content

scholarly journals Muscle stem cell dysfunction impairs muscle regeneration in a mouse model of Down syndrome

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Bradley Pawlikowski ◽  
Nicole Dalla Betta ◽  
Tiffany Elston ◽  
Darian A. Williams ◽  
Bradley B. Olwin
Keyword(s):  
Down Syndrome ◽  
Stem Cell ◽  
Mouse Model ◽  
Muscle Regeneration ◽  
Muscle Stem Cell ◽  
Cell Dysfunction

scholarly journals Extracellular Vesicles From Adipose Stem Cells Prevent Muscle Damage and Inflammation in a Mouse Model of Hind Limb Ischemia

2020 ◽  
Vol 40 (1) ◽  
pp. 239-254 ◽  
Author(s):  
Federico Figliolini ◽  
Andrea Ranghino ◽  
Cristina Grange ◽  
Massimo Cedrino ◽  
Marta Tapparo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Muscle Damage ◽  
Extracellular Vesicles ◽  
Muscle Regeneration ◽  
Hindlimb Ischemia ◽  
Vascular Growth ◽  
Muscle Protection

Objectives: Critical hindlimb ischemia is a severe consequence of peripheral artery disease. Surgical treatment does not prevent skeletal muscle impairment or improve long-term patient outcomes. The present study investigates the protective/regenerative potential and the mechanism of action of adipose stem cell-derived extracellular vesicles (ASC-EVs) in a mouse model of hindlimb ischemia. Approach and Results: We demonstrated that ASC-EVs exert a protective effect on muscle damage by acting both on tissue microvessels and muscle cells. The genes involved in muscle regeneration were up-regulated in the ischemic muscles of ASC-EV-treated animals. MyoD expression has also been confirmed in satellite cells. This was followed by a reduction in muscle function impairment in vivo. ASC-EVs drive myoblast proliferation and differentiation in the in vitro ischemia/reoxygenation model. Moreover, ASC-EVs have shown an anti-apoptotic effect both in vitro and in vivo. Transcriptomic analyses have revealed that ASC-EVs carry a variety of pro-angiogenic mRNAs, while proteomic analyses have demonstrated an enrichment of NRG1 (neuregulin 1). A NRG1 blocking antibody used in vivo demonstrated that NRG1 is relevant to ASC-EV-induced muscle protection, vascular growth, and recruitment of inflammatory cells. Finally, bioinformatic analyses on 18 molecules that were commonly detected in ASC-EVs, including mRNAs and proteins, confirmed the enrichment of pathways involved in vascular growth and muscle regeneration/protection. Conclusions: This study demonstrates that ASC-EVs display pro-angiogenic and skeletal muscle protective properties that are associated with their NRG1/mRNA cargo. We, therefore, propose that ASC-EVs are a useful tool for therapeutic angiogenesis and muscle protection.

scholarly journals Melittin – A bee venom component – Enhances muscle regeneration factors expression in a mouse model of skeletal muscle contusion

2019 ◽  
Vol 140 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Jae Eun Lee ◽  
Vikash Kumar Shah ◽  
Eun-Jung Lee ◽  
Min-Seok Oh ◽  
Jeong June Choi
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Muscle Regeneration ◽  
Bee Venom ◽  
Venom Component ◽  
Skeletal Muscle Contusion

scholarly journals EphA7+ perivascular cells as myogenic and angiogenic precursors improving skeletal muscle regeneration in a muscular dystrophic mouse model

2020 ◽  
Vol 47 ◽  
pp. 101914
Author(s):  
Kohei Kano ◽  
Kiwamu Horiuchi ◽  
Yuri Yoshida ◽  
Taiki Hayasaka ◽  
Maki Kabara ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration ◽  
Perivascular Cells ◽  
Dystrophic Mouse

scholarly journals Osteopontin deficiency delays inflammatory infiltration and the onset of muscle regeneration in a mouse model of muscle injury

2012 ◽  
Vol 6 (1) ◽  
pp. 197-205 ◽  
Author(s):  
K. Uaesoontrachoon ◽  
D. K. Wasgewatte Wijesinghe ◽  
E. J. Mackie ◽  
C. N. Pagel
Keyword(s):  
Mouse Model ◽  
Muscle Regeneration ◽  
Muscle Injury ◽  
Inflammatory Infiltration

scholarly journals Sonic Hedgehog Therapy in a Mouse Model of Age-Associated Impairment of Skeletal Muscle Regeneration

2013 ◽  
Vol 69A (3) ◽  
pp. 245-252 ◽  
Author(s):  
A. Piccioni ◽  
E. Gaetani ◽  
V. Neri ◽  
I. Gatto ◽  
M. Palladino ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Sonic Hedgehog ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration

scholarly journals Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury

2018 ◽  
Vol 225 (3) ◽  
Author(s):  
David Scully ◽  
Peggy Sfyri ◽  
Sandrine Verpoorten ◽  
Petros Papadopoulos ◽  
María Carmen Muñoz‐Turrillas ◽  
...  
Keyword(s):  
Stem Cell ◽  
Muscle Regeneration ◽  
Acute Injury ◽  
Skeletal Myogenesis ◽  
Muscle Stem Cell ◽  
Platelet Releasate ◽  
Cell Commitment

Effect of low-intensity pulsed ultrasound on skeletal muscle regeneration after cardiotoxin-induced damage in a mouse model

Physiotherapy ◽  
2015 ◽  
Vol 101 ◽  
pp. e1070-e1071
Author(s):  
A. Nakamura ◽  
M. Sakamoto ◽  
C. Moriya ◽  
A. Matsunaga
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity
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