scholarly journals β-Adrenergic modulation of skeletal muscle contraction: key role of excitation-contraction coupling

2015 ◽  
Vol 593 (21) ◽  
pp. 4713-4727 ◽  
Author(s):  
Simeon P. Cairns ◽  
Fabio Borrani
Keyword(s):  
Skeletal Muscle ◽  
Muscle Contraction ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Skeletal Muscle Contraction ◽  
Adrenergic Modulation

Extracellular divalent cations in excitation–contraction coupling: hypertonic solution effects

1982 ◽  
Vol 60 (4) ◽  
pp. 440-445
Author(s):  
Isao Oota ◽  
Isao Kosaka ◽  
Torao Nagai ◽  
Hideyo Yabu
Keyword(s):  
Skeletal Muscle ◽  
Divalent Cations ◽  
Muscle Fibers ◽  
Hypertonic Solution ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Skeletal Muscle Fibers ◽  
Membrane Bound

It is the purpose of this article to point out that the membrane-bound Ca plays an important role in excitation–contraction (E–C) coupling of skeletal muscle fibers and that other divalent cations are unable to substitute for this role of membrane-bound Ca.

scholarly journals The Role of the Four Ca Binding Sites of Troponin C in the Regulation of Skeletal Muscle Contraction

1996 ◽  
Vol 271 (14) ◽  
pp. 8381-8386 ◽  
Author(s):  
Danuta Szczesna ◽  
Georgianna Guzman ◽  
Todd Miller ◽  
Jiaju Zhao ◽  
Kamelia Farokhi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Contraction ◽  
Binding Sites ◽  
Troponin C ◽  
Skeletal Muscle Contraction

scholarly journals Unique role of skeletal muscle contraction in vertical lymph movement in anurans

2007 ◽  
Vol 210 (22) ◽  
pp. 3931-3939 ◽  
Author(s):  
R. C. Drewes ◽  
M. S. Hedrick ◽  
S. S. Hillman ◽  
P. C. Withers
Keyword(s):  
Skeletal Muscle ◽  
Muscle Contraction ◽  
Unique Role ◽  
Skeletal Muscle Contraction

scholarly journals The IQ Motif is Crucial for Cav1.1 Function

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Katarina Stroffekova
Keyword(s):  
Skeletal Muscle ◽  
High Voltage ◽  
Functional Coupling ◽  
Charge Movement ◽  
Excitation Contraction Coupling ◽  
Whole Cell ◽  
Iq Motif ◽  
Contraction Coupling

Ca2+-dependent modulation via calmodulin, with consensus CaM-binding IQ motif playing a key role, has been documented for most high-voltage-activated Ca2+channels. The skeletal muscle Cav1.1 also exhibits Ca2+-/CaM-dependent modulation. Here, whole-cell Ca2+current, Ca2+transient, and maximal, immobilization-resistant charge movement(Qmax)recordings were obtained from cultured mouse myotubes, to test a role of IQ motif in function of Cav1.1. The effect of introducing mutation (IQ to AA) of IQ motif into Cav1.1 was examined. In dysgenic myotubes expressing YFP-Cav1.1AA, neither Ca2+currents nor evoked Ca2+transients were detectable. The loss of Ca2+current and excitation-contraction coupling did not appear to be a consequence of defective trafficking to the sarcolemma. TheQmaxin dysgenic myotubes expressing YFP-Cav1.1AAwas similar to that of normal myotubes. These findings suggest that the IQ motif of the Cav1.1 may be an unrecognized site of structural and functional coupling between DHPR and RyR.

scholarly journals The Role of Ryanodine Receptor Phosphorylation in Skeletal Muscle Excitation-Contraction Coupling

2011 ◽  
Vol 100 (3) ◽  
pp. 592a
Author(s):  
Matthew J. Betzenhauser ◽  
Daniel C. Andersson ◽  
Steven Reiken ◽  
Andrew R. Marks
Keyword(s):  
Skeletal Muscle ◽  
Ryanodine Receptor ◽  
Receptor Phosphorylation ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling

scholarly journals Mechanisms of Skeletal Muscle Contraction‐Induced Rapid Vasodilation in Humans: Role of Vascular Hyperpolarization

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Brett S Kirby ◽  
Anne R Crecelius ◽  
Jennifer C Richards ◽  
Leora J Garcia ◽  
Gary J Luckasen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Contraction ◽  
Skeletal Muscle Contraction
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