Regulation of excitation‐contraction coupling at the Drosophila neuromuscular junction

2021 ◽  
Author(s):  
Kiel G. Ormerod ◽  
Anthony E. Scibelli ◽  
J. Troy Littleton
Keyword(s):  
Neuromuscular Junction ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling

scholarly journals Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yankun Lyu ◽  
Vipin K. Verma ◽  
Younjee Lee ◽  
Iosif Taleb ◽  
Rachit Badolia ◽  
...  
Keyword(s):  
Heart Function ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Excitation Contraction Coupling ◽  
Transverse Tubular System ◽  
Contraction Coupling ◽  
Senescent Phenotype ◽  
Cellular Microstructure ◽  
T System

AbstractIt is well established that the aging heart progressively remodels towards a senescent phenotype, but alterations of cellular microstructure and their differences to chronic heart failure (HF) associated remodeling remain ill-defined. Here, we show that the transverse tubular system (t-system) and proteins underlying excitation-contraction coupling in cardiomyocytes are characteristically remodeled with age. We shed light on mechanisms of this remodeling and identified similarities and differences to chronic HF. Using left ventricular myocardium from donors and HF patients with ages between 19 and 75 years, we established a library of 3D reconstructions of the t-system as well as ryanodine receptor (RyR) and junctophilin 2 (JPH2) clusters. Aging was characterized by t-system alterations and sarcolemmal dissociation of RyR clusters. This remodeling was less pronounced than in HF and accompanied by major alterations of JPH2 arrangement. Our study indicates that targeting sarcolemmal association of JPH2 might ameliorate age-associated deficiencies of heart function.

scholarly journals 112 THE AGE DEPENDENCY OF MYOCARDIAL EXCITATION CONTRACTION COUPLING

1985 ◽  
Vol 19 (4) ◽  
pp. 129A-129A
Author(s):  
Thomas S Klitzner ◽  
William F Friedman
Keyword(s):  
Age Dependency ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling

scholarly journals Age and gender differences in excitation-contraction coupling of the rat ventricle

1998 ◽  
Vol 511 (2) ◽  
pp. 533-548 ◽  
Author(s):  
Normand Leblanc ◽  
Denis Chartier ◽  
Hugues Gosselin ◽  
Jean-Lucien Rouleau
Keyword(s):  
Gender Differences ◽  
Age And Gender ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Age And Gender Differences ◽  
And Gender ◽  
Rat Ventricle

scholarly journals Myocardial Excitation-contraction Coupling in the Fetus of Alloxan-diabetic Rabbit

1984 ◽  
Vol 18 (12) ◽  
pp. 1344-1349 ◽  
Author(s):  
Toshio Nakanishi ◽  
Suguru Matsuoka ◽  
Shigeru Uemura ◽  
Tatsuo Shimizu ◽  
Kenya Nishioka ◽  
...  
Keyword(s):  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Diabetic Rabbit
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