scholarly journals The effect of sodium and calcium on the action potential of the smooth muscle of the guinea-pig taenia coli

1969 ◽  
Vol 200 (3) ◽  
pp. 637-654 ◽  
Author(s):  
Alison Brading ◽  
Edith Bülbring ◽  
T. Tomita
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Action Potential ◽  
Taenia Coli

scholarly journals The Action Potential in the Smooth Muscle of the Guinea Pig Taenia Coli and Ureter Studied by the Double Sucrose-Gap Method

1970 ◽  
Vol 55 (2) ◽  
pp. 147-162 ◽  
Author(s):  
H. Kuriyama ◽  
T. Tomita
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Action Potential ◽  
Membrane Resistance ◽  
Taenia Coli ◽  
Free Solution ◽  
Ureter Replacement ◽  
A Cell ◽  
Sucrose Gap ◽  
Electrotonic Potential

The configuration of the electrotonic potential and the action potential observed by the double sucrose-gap method was similar to that observed with a microelectrode inserted into a cell in the center pool between the gaps. In the taenia and the ureter, the evoked spike was larger in low Na or in Na-free (sucrose substitute) solution than in normal solution. However, the plateau component in the ureter was suppressed in the absence of Na. In Ca-free solution containing Mg (3–5 mM) and Na (137 mM), the membrane potential and membrane resistance were normal, but no spike could be elicited in both the taenia and ureter. Replacement of Ca with Sr did not affect the spike in the taenia, nor the spike component of the ureter but prolonged the plateau component. The prolonged plateau disappeared on removal of Na, while repetitive spikes could still be evoked. It was concluded that the spike activity in the taenia and in the ureter of the guinea pig is due to Ca entry, that the plateau component in the ureter is due to an increase in the Na conductance of the membrane, and that both mechanisms, for the spike and for the plateau, are separately controlled by Ca bound in the membrane.

Cholinergic nerve-mediated excitation in the guinea pig choledochoduodenal junction activated by distension

1994 ◽  
Vol 267 (5) ◽  
pp. G938-G946 ◽  
Author(s):  
F. Vogalis ◽  
R. R. Bywater ◽  
G. S. Taylor
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Action Potential ◽  
Action Potentials ◽  
Discharge Rate ◽  
Circular Muscle ◽  
Muscle Layer ◽  
Circular Muscle Layer ◽  
Circular Layer ◽  
Longitudinal Layer

The electrical basis of propulsive contractions in the guinea pig choledochoduodenal junction (CDJ), which are triggered by distension, was investigated using intracellular microelectrode recording techniques. The isolated CDJ was placed in a continuously perfused tissue chamber at 37 degrees C. Membrane potential was recorded from smooth muscle cells in either the ampulla or in the upper CDJ (upper junction) regions, which were immobilized by pinning. Distension of the upper junction (20-30 s) by increasing intraductal hydrostatic pressure (mean elevation: 2.0 +/- 0.3 kPa, n = 13) triggered "transient depolarizations" (TDs: < 5 mV in amplitude and 2-5 s in duration) and action potentials in the circular muscle layer of the ampulla. The frequency of TDs in the ampulla was increased from 2.2 +/- 0.2 to 15.9 +/- 2.2 min-1 (n = 13) during distension. Simultaneous impalements of cells in the longitudinal and circular muscle layers in the ampulla revealed that subthreshold TDs in the circular layer were associated with an increased rate of action potential discharge in the longitudinal layer. Atropine (Atr; 1.4 x 10(-6) M) and tetrodotoxin (TTX; 3.1 x 10(-6) M blocked the distension-evoked increase in TD frequency, without affecting the frequency of ongoing TDs. The sulfated octapeptide of cholecystokinin (1-5 x 10(-8) M) increased the amplitude of TDs recorded in the circular muscle layer of the ampulla and increased action potential discharge rate. In separate recordings, radial stretch of the ampulla region increased the rate of discharge of action potentials in the smooth muscle of the upper junction.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Mechanics of guinea pig taenia coli smooth muscle during anoxia and rigor

1975 ◽  
Vol 229 (6) ◽  
pp. 1727-1727
Author(s):  
D. Bose ◽  
R. Bose
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Taenia Coli ◽  
First Line

Page 324: D. Bose and R. Bose. "Mechanics of guinea pig taenia coli smooth muscle during anoxia and rigor." Page 326: in legend to Fig. 4A, first line, "6%" should read "2.5%." In Fig. 6, on the isotonic scale on the ordinate, "2.3" and "3.3" should be interchanged.

scholarly journals Effect of DFP on loading of fura-2/AM into single smooth muscle cells prepared from guinea pig taenia coli

1987 ◽  
Vol 43 ◽  
pp. 240
Author(s):  
Hideto Oyamada ◽  
Ikuo Maruyama ◽  
Tomohiko Hasegawa ◽  
Kazuko Otsuka ◽  
Kazutaka Momose
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Taenia Coli ◽  
Fura 2
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